Pharmacological effects of combined antitubercular preparation "Protub-3®" at single introduction in experimental conditions
An experimental preclinical study of combined antitubercular preparation "Protub-3®" was conducted. Under conditions of performed research "Protub-3®" in dose 8 mg/kg didn't cause pharmacological effect in all registered indices in experiment. But it was established that the...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2013-09-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/1664 |
| _version_ | 1797237527954849792 |
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| author | K. I. Usov G. G. Yushkov |
| author_facet | K. I. Usov G. G. Yushkov |
| author_sort | K. I. Usov |
| collection | DOAJ |
| description | An experimental preclinical study of combined antitubercular preparation "Protub-3®" was conducted. Under conditions of performed research "Protub-3®" in dose 8 mg/kg didn't cause pharmacological effect in all registered indices in experiment. But it was established that the preparation in doses more than 8 mg/kg caused a number of dose-dependent pharmacological effects. Increase of rectal temperature, systolic arterial pressure, sum-liminal index, consumption of oxygen and simultaneous decrease of carbonic gas emission, decrease of duration of hexenal sleep, decrease of heart rate, suppression of spontaneous motive activity, rats' research reflex can be related to the number of estimation effects of "Protub-3®". |
| first_indexed | 2024-03-08T12:19:35Z |
| format | Article |
| id | doaj.art-10178764fc25443a89ddd46c8f7625a8 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:21:10Z |
| publishDate | 2013-09-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-10178764fc25443a89ddd46c8f7625a82024-03-28T07:49:11ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962013-09-01051581611610Pharmacological effects of combined antitubercular preparation "Protub-3®" at single introduction in experimental conditionsK. I. Usov0G. G. Yushkov1Angarsk State Technical AcademyAngarsk State Technical AcademyAn experimental preclinical study of combined antitubercular preparation "Protub-3®" was conducted. Under conditions of performed research "Protub-3®" in dose 8 mg/kg didn't cause pharmacological effect in all registered indices in experiment. But it was established that the preparation in doses more than 8 mg/kg caused a number of dose-dependent pharmacological effects. Increase of rectal temperature, systolic arterial pressure, sum-liminal index, consumption of oxygen and simultaneous decrease of carbonic gas emission, decrease of duration of hexenal sleep, decrease of heart rate, suppression of spontaneous motive activity, rats' research reflex can be related to the number of estimation effects of "Protub-3®".https://www.actabiomedica.ru/jour/article/view/1664antitubercular preparationcombined preparationisoniazidrifampicinpiraziamidsynthetic antibacterial meansansamicinescollateral reactionspharmacological effect |
| spellingShingle | K. I. Usov G. G. Yushkov Pharmacological effects of combined antitubercular preparation "Protub-3®" at single introduction in experimental conditions Acta Biomedica Scientifica antitubercular preparation combined preparation isoniazid rifampicin piraziamid synthetic antibacterial means ansamicines collateral reactions pharmacological effect |
| title | Pharmacological effects of combined antitubercular preparation "Protub-3®" at single introduction in experimental conditions |
| title_full | Pharmacological effects of combined antitubercular preparation "Protub-3®" at single introduction in experimental conditions |
| title_fullStr | Pharmacological effects of combined antitubercular preparation "Protub-3®" at single introduction in experimental conditions |
| title_full_unstemmed | Pharmacological effects of combined antitubercular preparation "Protub-3®" at single introduction in experimental conditions |
| title_short | Pharmacological effects of combined antitubercular preparation "Protub-3®" at single introduction in experimental conditions |
| title_sort | pharmacological effects of combined antitubercular preparation protub 3 r at single introduction in experimental conditions |
| topic | antitubercular preparation combined preparation isoniazid rifampicin piraziamid synthetic antibacterial means ansamicines collateral reactions pharmacological effect |
| url | https://www.actabiomedica.ru/jour/article/view/1664 |
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