Neurological manifestations of patients with mild-to-moderate COVID-19 attending a public hospital in Lima, Peru
Objective: To determine the prevalence and characteristics of the most common neurological manifestations in Peruvian patients with mild-to-moderate COVID-19. Methods: We conducted a single-center prospective, cross-sectional study at an isolation center functioning as a public acute-care hospital d...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | eNeurologicalSci |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405650221000307 |
| _version_ | 1824046165423816704 |
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| author | Marco H. Carcamo Garcia Diego D. Garcia Choza Brenda J. Salazar Linares Monica M. Diaz |
| author_facet | Marco H. Carcamo Garcia Diego D. Garcia Choza Brenda J. Salazar Linares Monica M. Diaz |
| author_sort | Marco H. Carcamo Garcia |
| collection | DOAJ |
| description | Objective: To determine the prevalence and characteristics of the most common neurological manifestations in Peruvian patients with mild-to-moderate COVID-19. Methods: We conducted a single-center prospective, cross-sectional study at an isolation center functioning as a public acute-care hospital during the COVID-19 pandemic in Lima, the capital city of Peru. This was a convenience sample of patients with acute COVID-19 infection and mild-to-moderate respiratory symptoms who presented for hospital admission between September 25 and November 25, 2020. We interviewed participants and collected demographic, medical history and clinical presentation data; all participants underwent a complete physical and neurological examination. Descriptive statistics and prevalence ratios (PR) with corresponding 95% confidence intervals and p-values were calculated to explore between-groups differences. Results: Of 199 patients with mild-to-moderate COVID-19 enrolled in this study, 83% presented with at least one neurological symptom (mean symptom duration 8 +/− 6 days). The most common neurological symptoms were headache (72%), hypogeusia or ageusia (41%), hyposmia or anosmia (40%) and dizziness (34%). Only 2.5% of the cohort had an abnormal neurological examination. The majority (42%) had no prior comorbidities. Presence of at least 1 neurological symptom was independently associated with fever, dyspnea, cough, poor appetite, sore throat, chest tightness or diarrhea, but not with comorbid conditions. Conclusions: This cross-sectional study found that headaches, and smell and taste dysfunction are common among patients presenting with mild-to-moderate acute COVID-19 in Lima, Peru. International longitudinal studies are needed to determine the long-term neurological sequelae of COVID-19 during the acute and post-infectious period. |
| first_indexed | 2024-12-23T00:30:55Z |
| format | Article |
| id | doaj.art-1017af9862f04e788445d7bbf277b721 |
| institution | Directory Open Access Journal |
| issn | 2405-6502 |
| language | English |
| last_indexed | 2024-12-23T00:30:55Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | eNeurologicalSci |
| spelling | doaj.art-1017af9862f04e788445d7bbf277b7212022-12-21T18:06:56ZengElseviereNeurologicalSci2405-65022021-06-0123100338Neurological manifestations of patients with mild-to-moderate COVID-19 attending a public hospital in Lima, PeruMarco H. Carcamo Garcia0Diego D. Garcia Choza1Brenda J. Salazar Linares2Monica M. Diaz3Epidemiology, STD, and HIV Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru; Care and Isolation Center for COVID-19 Patients Villa Panamericana, EsSalud - Social Health Insurance Institute, Lima, PeruCare and Isolation Center for COVID-19 Patients Villa Panamericana, EsSalud - Social Health Insurance Institute, Lima, Peru; Universidad de San Martín de Porres, Lima, PeruCare and Isolation Center for COVID-19 Patients Villa Panamericana, EsSalud - Social Health Insurance Institute, Lima, Peru; Universidad de San Martín de Porres, Lima, PeruEpidemiology, STD, and HIV Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru; Department of Neurology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA; Corresponding author at: Department of Neurology, University of North Carolina at Chapel Hill, 170 Manning Drive, Campus Box 7025, Chapel Hill, NC 27599-7025, USA.Objective: To determine the prevalence and characteristics of the most common neurological manifestations in Peruvian patients with mild-to-moderate COVID-19. Methods: We conducted a single-center prospective, cross-sectional study at an isolation center functioning as a public acute-care hospital during the COVID-19 pandemic in Lima, the capital city of Peru. This was a convenience sample of patients with acute COVID-19 infection and mild-to-moderate respiratory symptoms who presented for hospital admission between September 25 and November 25, 2020. We interviewed participants and collected demographic, medical history and clinical presentation data; all participants underwent a complete physical and neurological examination. Descriptive statistics and prevalence ratios (PR) with corresponding 95% confidence intervals and p-values were calculated to explore between-groups differences. Results: Of 199 patients with mild-to-moderate COVID-19 enrolled in this study, 83% presented with at least one neurological symptom (mean symptom duration 8 +/− 6 days). The most common neurological symptoms were headache (72%), hypogeusia or ageusia (41%), hyposmia or anosmia (40%) and dizziness (34%). Only 2.5% of the cohort had an abnormal neurological examination. The majority (42%) had no prior comorbidities. Presence of at least 1 neurological symptom was independently associated with fever, dyspnea, cough, poor appetite, sore throat, chest tightness or diarrhea, but not with comorbid conditions. Conclusions: This cross-sectional study found that headaches, and smell and taste dysfunction are common among patients presenting with mild-to-moderate acute COVID-19 in Lima, Peru. International longitudinal studies are needed to determine the long-term neurological sequelae of COVID-19 during the acute and post-infectious period.http://www.sciencedirect.com/science/article/pii/S2405650221000307COVID-19NeurologicalLatin AmericaPeruHeadache |
| spellingShingle | Marco H. Carcamo Garcia Diego D. Garcia Choza Brenda J. Salazar Linares Monica M. Diaz Neurological manifestations of patients with mild-to-moderate COVID-19 attending a public hospital in Lima, Peru eNeurologicalSci COVID-19 Neurological Latin America Peru Headache |
| title | Neurological manifestations of patients with mild-to-moderate COVID-19 attending a public hospital in Lima, Peru |
| title_full | Neurological manifestations of patients with mild-to-moderate COVID-19 attending a public hospital in Lima, Peru |
| title_fullStr | Neurological manifestations of patients with mild-to-moderate COVID-19 attending a public hospital in Lima, Peru |
| title_full_unstemmed | Neurological manifestations of patients with mild-to-moderate COVID-19 attending a public hospital in Lima, Peru |
| title_short | Neurological manifestations of patients with mild-to-moderate COVID-19 attending a public hospital in Lima, Peru |
| title_sort | neurological manifestations of patients with mild to moderate covid 19 attending a public hospital in lima peru |
| topic | COVID-19 Neurological Latin America Peru Headache |
| url | http://www.sciencedirect.com/science/article/pii/S2405650221000307 |
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