Technological Approaches for Improving Vaccination Compliance and Coverage
Vaccination has been well recognised as a critically important tool in preventing infectious disease, yet incomplete immunisation coverage remains a major obstacle to achieving disease control and eradication. As medical products for global access, vaccines need to be safe, effective and inexpensive...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/8/2/304 |
| _version_ | 1797565208095358976 |
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| author | Céline Lemoine Aneesh Thakur Danina Krajišnik Romain Guyon Stephanie Longet Agnieszka Razim Sabina Górska Ivana Pantelić Tanja Ilić Ines Nikolić Ed C. Lavelle Andrzej Gamian Snežana Savić Anita Milicic |
| author_facet | Céline Lemoine Aneesh Thakur Danina Krajišnik Romain Guyon Stephanie Longet Agnieszka Razim Sabina Górska Ivana Pantelić Tanja Ilić Ines Nikolić Ed C. Lavelle Andrzej Gamian Snežana Savić Anita Milicic |
| author_sort | Céline Lemoine |
| collection | DOAJ |
| description | Vaccination has been well recognised as a critically important tool in preventing infectious disease, yet incomplete immunisation coverage remains a major obstacle to achieving disease control and eradication. As medical products for global access, vaccines need to be safe, effective and inexpensive. In line with these goals, continuous improvements of vaccine delivery strategies are necessary to achieve the full potential of immunisation. Novel technologies related to vaccine delivery and route of administration, use of advanced adjuvants and controlled antigen release (single-dose immunisation) approaches are expected to contribute to improved coverage and patient compliance. This review discusses the application of micro- and nano-technologies in the alternative routes of vaccine administration (mucosal and cutaneous vaccination), oral vaccine delivery as well as vaccine encapsulation with the aim of controlled antigen release for single-dose vaccination. |
| first_indexed | 2024-03-10T19:08:50Z |
| format | Article |
| id | doaj.art-10187caa5463421ab68b71f344b6299e |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T19:08:50Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-10187caa5463421ab68b71f344b6299e2023-11-20T03:57:51ZengMDPI AGVaccines2076-393X2020-06-018230410.3390/vaccines8020304Technological Approaches for Improving Vaccination Compliance and CoverageCéline Lemoine0Aneesh Thakur1Danina Krajišnik2Romain Guyon3Stephanie Longet4Agnieszka Razim5Sabina Górska6Ivana Pantelić7Tanja Ilić8Ines Nikolić9Ed C. Lavelle10Andrzej Gamian11Snežana Savić12Anita Milicic13Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1221 Geneva, SwitzerlandDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, DenmarkDepartment of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, SerbiaThe Jenner Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UKVirology & Pathogenesis Group, Public Health England, Manor Farm Road, Porton Down, Salisbury SP4 0JG, UKDepartment of Microbiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul. Rudolfa Weigla 12, 53-114 Wroclaw, PolandDepartment of Microbiology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul. Rudolfa Weigla 12, 53-114 Wroclaw, PolandDepartment of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, SerbiaThe Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, DO2R590 Dublin, IrelandDepartment of Immunology of Infectious Diseases, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul. Rudolfa Weigla 12, 53-114 Wroclaw, PolandDepartment of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, SerbiaThe Jenner Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UKVaccination has been well recognised as a critically important tool in preventing infectious disease, yet incomplete immunisation coverage remains a major obstacle to achieving disease control and eradication. As medical products for global access, vaccines need to be safe, effective and inexpensive. In line with these goals, continuous improvements of vaccine delivery strategies are necessary to achieve the full potential of immunisation. Novel technologies related to vaccine delivery and route of administration, use of advanced adjuvants and controlled antigen release (single-dose immunisation) approaches are expected to contribute to improved coverage and patient compliance. This review discusses the application of micro- and nano-technologies in the alternative routes of vaccine administration (mucosal and cutaneous vaccination), oral vaccine delivery as well as vaccine encapsulation with the aim of controlled antigen release for single-dose vaccination.https://www.mdpi.com/2076-393X/8/2/304vaccine deliverycompliancemicrofluidicsmucosal vaccinationcutaneous vaccinationadjuvants |
| spellingShingle | Céline Lemoine Aneesh Thakur Danina Krajišnik Romain Guyon Stephanie Longet Agnieszka Razim Sabina Górska Ivana Pantelić Tanja Ilić Ines Nikolić Ed C. Lavelle Andrzej Gamian Snežana Savić Anita Milicic Technological Approaches for Improving Vaccination Compliance and Coverage Vaccines vaccine delivery compliance microfluidics mucosal vaccination cutaneous vaccination adjuvants |
| title | Technological Approaches for Improving Vaccination Compliance and Coverage |
| title_full | Technological Approaches for Improving Vaccination Compliance and Coverage |
| title_fullStr | Technological Approaches for Improving Vaccination Compliance and Coverage |
| title_full_unstemmed | Technological Approaches for Improving Vaccination Compliance and Coverage |
| title_short | Technological Approaches for Improving Vaccination Compliance and Coverage |
| title_sort | technological approaches for improving vaccination compliance and coverage |
| topic | vaccine delivery compliance microfluidics mucosal vaccination cutaneous vaccination adjuvants |
| url | https://www.mdpi.com/2076-393X/8/2/304 |
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