The Need for Cervical Cancer Control in HIV-Positive and HIV-Negative Women from Romania by Primary Prevention and by Early Detection Using Clinically Validated HPV/DNA Tests.
In Romania, a country with no organized national surveillance program regarding cervical cancer, the early diagnosis of HPV (Human Papilloma Virus) infections is a major requirement, especially in HIV-infected women. The objective of this study was to determine the HPV prevalence and type distributi...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4506070?pdf=render |
| _version_ | 1818275533940588544 |
|---|---|
| author | Ramona Gabriela Ursu Mircea Onofriescu Alexandru Luca Liviu Jany Prisecariu Silvia Olivia Sălceanu Dragoş Nemescu Luminiţa Smaranda Iancu |
| author_facet | Ramona Gabriela Ursu Mircea Onofriescu Alexandru Luca Liviu Jany Prisecariu Silvia Olivia Sălceanu Dragoş Nemescu Luminiţa Smaranda Iancu |
| author_sort | Ramona Gabriela Ursu |
| collection | DOAJ |
| description | In Romania, a country with no organized national surveillance program regarding cervical cancer, the early diagnosis of HPV (Human Papilloma Virus) infections is a major requirement, especially in HIV-infected women. The objective of this study was to determine the HPV prevalence and type distribution in young HIV-positive women and to assess the difference in the risk factors for developing cervical cancer compared to those of HIV-negative women.We conducted one cross-sectional cohort study from June 2013-September 2014, including 1,032 women: 992 HIV- women who were 36.5 years old (limits: 17 ÷ 84) and 40 HIV + women who were 22.9 years old (limits: 17 ÷ 30) with iatrogenic HIV infected. We detected HPV types with the Linear Array HPV Genotyping test (Roche, Romania).DNA/HPV was detected in 18/40 (45%) of the HIV+ patients and in 350/992 (35.2%) of the HIV- patients (OR = 1.5, 95%CI 0.76÷2.96). After age adjustment, the overall HPV prevalence was 51.6% in HIV+ versus 63.2% in HIV- women aged under 25, and 22.2% in HPV+ versus 47.2% in HIV- women aged 25-34. We detect HIV being a risk factor for acquiring multiple HPV type infections (OR = 2.30, 95% CI 0.88÷5.97). The eight most common HPV types (high-risk, and low-risk) for women below age 30, HIV+ / - were: HPV 16, 18, 31, 51, 58, 68, and 6 and 82 respectively. To assess the risk factors of HIV-positive women for acquiring HPV infection, we analyzed the CD4/μL, ARN/HIV copies/μL, the age group, the number of sexual partners, smoking, and the type of HPV infection (single versus multiple infections). We found that the number of sexual partners and smoking are statistically significant risk factors.Even though there are no significant differences regarding the prevalence of HPV infection in HIV + versus HIV - patients, multiple infections were more frequent in the first group. In our study group young HIV-infected patients under HAART therapy, high number of sexual partners (more than 3) and smoking were detected to be risk factors. Future organized screening for HPV infection using sensitive and specific methods are necessary at the national level in Romania. |
| first_indexed | 2024-12-12T22:31:16Z |
| format | Article |
| id | doaj.art-101c032a25b14edaaa95f0f61667e27a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T22:31:16Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-101c032a25b14edaaa95f0f61667e27a2022-12-22T00:09:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01107e013227110.1371/journal.pone.0132271The Need for Cervical Cancer Control in HIV-Positive and HIV-Negative Women from Romania by Primary Prevention and by Early Detection Using Clinically Validated HPV/DNA Tests.Ramona Gabriela UrsuMircea OnofriescuAlexandru LucaLiviu Jany PrisecariuSilvia Olivia SălceanuDragoş NemescuLuminiţa Smaranda IancuIn Romania, a country with no organized national surveillance program regarding cervical cancer, the early diagnosis of HPV (Human Papilloma Virus) infections is a major requirement, especially in HIV-infected women. The objective of this study was to determine the HPV prevalence and type distribution in young HIV-positive women and to assess the difference in the risk factors for developing cervical cancer compared to those of HIV-negative women.We conducted one cross-sectional cohort study from June 2013-September 2014, including 1,032 women: 992 HIV- women who were 36.5 years old (limits: 17 ÷ 84) and 40 HIV + women who were 22.9 years old (limits: 17 ÷ 30) with iatrogenic HIV infected. We detected HPV types with the Linear Array HPV Genotyping test (Roche, Romania).DNA/HPV was detected in 18/40 (45%) of the HIV+ patients and in 350/992 (35.2%) of the HIV- patients (OR = 1.5, 95%CI 0.76÷2.96). After age adjustment, the overall HPV prevalence was 51.6% in HIV+ versus 63.2% in HIV- women aged under 25, and 22.2% in HPV+ versus 47.2% in HIV- women aged 25-34. We detect HIV being a risk factor for acquiring multiple HPV type infections (OR = 2.30, 95% CI 0.88÷5.97). The eight most common HPV types (high-risk, and low-risk) for women below age 30, HIV+ / - were: HPV 16, 18, 31, 51, 58, 68, and 6 and 82 respectively. To assess the risk factors of HIV-positive women for acquiring HPV infection, we analyzed the CD4/μL, ARN/HIV copies/μL, the age group, the number of sexual partners, smoking, and the type of HPV infection (single versus multiple infections). We found that the number of sexual partners and smoking are statistically significant risk factors.Even though there are no significant differences regarding the prevalence of HPV infection in HIV + versus HIV - patients, multiple infections were more frequent in the first group. In our study group young HIV-infected patients under HAART therapy, high number of sexual partners (more than 3) and smoking were detected to be risk factors. Future organized screening for HPV infection using sensitive and specific methods are necessary at the national level in Romania.http://europepmc.org/articles/PMC4506070?pdf=render |
| spellingShingle | Ramona Gabriela Ursu Mircea Onofriescu Alexandru Luca Liviu Jany Prisecariu Silvia Olivia Sălceanu Dragoş Nemescu Luminiţa Smaranda Iancu The Need for Cervical Cancer Control in HIV-Positive and HIV-Negative Women from Romania by Primary Prevention and by Early Detection Using Clinically Validated HPV/DNA Tests. PLoS ONE |
| title | The Need for Cervical Cancer Control in HIV-Positive and HIV-Negative Women from Romania by Primary Prevention and by Early Detection Using Clinically Validated HPV/DNA Tests. |
| title_full | The Need for Cervical Cancer Control in HIV-Positive and HIV-Negative Women from Romania by Primary Prevention and by Early Detection Using Clinically Validated HPV/DNA Tests. |
| title_fullStr | The Need for Cervical Cancer Control in HIV-Positive and HIV-Negative Women from Romania by Primary Prevention and by Early Detection Using Clinically Validated HPV/DNA Tests. |
| title_full_unstemmed | The Need for Cervical Cancer Control in HIV-Positive and HIV-Negative Women from Romania by Primary Prevention and by Early Detection Using Clinically Validated HPV/DNA Tests. |
| title_short | The Need for Cervical Cancer Control in HIV-Positive and HIV-Negative Women from Romania by Primary Prevention and by Early Detection Using Clinically Validated HPV/DNA Tests. |
| title_sort | need for cervical cancer control in hiv positive and hiv negative women from romania by primary prevention and by early detection using clinically validated hpv dna tests |
| url | http://europepmc.org/articles/PMC4506070?pdf=render |
| work_keys_str_mv | AT ramonagabrielaursu theneedforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT mirceaonofriescu theneedforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT alexandruluca theneedforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT liviujanyprisecariu theneedforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT silviaoliviasalceanu theneedforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT dragosnemescu theneedforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT luminitasmarandaiancu theneedforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT ramonagabrielaursu needforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT mirceaonofriescu needforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT alexandruluca needforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT liviujanyprisecariu needforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT silviaoliviasalceanu needforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT dragosnemescu needforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests AT luminitasmarandaiancu needforcervicalcancercontrolinhivpositiveandhivnegativewomenfromromaniabyprimarypreventionandbyearlydetectionusingclinicallyvalidatedhpvdnatests |