CD8<sup>+</sup> T Cell Senescence: Lights and Shadows in Viral Infections, Autoimmune Disorders and Cancer

CD8<sup>+</sup> T Cell Senescence: Lights and Shadows in Viral Infections, Autoimmune Disorders and Cancer

CD8<sup>+</sup> T lymphocytes are a heterogeneous class of cells that play a crucial role in the adaptive immune response against pathogens and cancer. During their lifetime, they acquire cytotoxic functions to ensure the clearance of infected or transformed cells and, in addition, they...

Full description

Bibliographic Details
Main Authors:	Valentina Tedeschi, Giorgia Paldino, Martina Kunkl, Marino Paroli, Rosa Sorrentino, Loretta Tuosto, Maria Teresa Fiorillo
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Series:	International Journal of Molecular Sciences
Subjects:	immune-senescence inflammaging CD28<sup>−</sup> CD57<sup>+</sup> CD8<sup>+</sup> T cells HIV CMV SARS-CoV-2
Online Access:	https://www.mdpi.com/1422-0067/23/6/3374

Similar Items

Senescent Tumor CD8<sup>+</sup> T Cells: Mechanisms of Induction and Challenges to Immunotherapy
by: Wei Liu, et al.
Published: (2020-09-01)

CELL-MEDIATED IMMUNITY IN PATIENTS WITH POSTTRAUMATIC LONG BONE OSTEOMYELITIS IN THE COURSE OF MANAGEMENT WITH THE ILIZAROV METHOD
by: M. V. Chepeleva, et al.
Published: (2019-02-01)

CD3<sup>+</sup>, CD8<sup>+</sup>, CD4<sup>+</sup> and FOXP3<sup>+</sup> T Cells in the Immune Microenvironment of Small Bowel Neuroendocrine Tumors
by: Niko Hiltunen, et al.
Published: (2021-06-01)

Effects of Chemotherapy on Hematological Parameters and CD4<sup>+</sup>/CD8<sup>+</sup> Ratio in Cats with Mediastinal Lymphoma and Seropositive to Feline Leukemia Virus
by: Tassanee Jaroensong, et al.
Published: (2022-01-01)

CD4<sup>+</sup>CD25<sup>+</sup> Cells Are Essential for Maintaining Immune Tolerance in Chickens Inoculated with Bovine Serum Albumin at the Late Stage of Embryonic Development
by: Xiaoxue Yu, et al.
Published: (2020-10-01)

A Population of CD4<sup>+</sup>CD8<sup>+</sup> Double-Positive T Cells Associated with Risk of Plasma Leakage in Dengue Viral Infection
by: Esther Dawen Yu, et al.
Published: (2022-01-01)

Expression of CD44 in Leukocyte Subpopulations in Patients with Inflammatory Bowel Diseases
by: Ivana Franić, et al.
Published: (2022-08-01)

In-vitro inhibition of IFNγ<sup>+</sup> iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg function
by: Daniel Volker, et al.
Published: (2012-08-01)

The Effect of a Linear Tuning between the Antigenic Stimulations of CD4<sup>+</sup> T Cells and CD4<sup>+</sup> Tregs
by: Aliyu A. Yusuf, et al.
Published: (2020-02-01)

Oclacitinib, a Janus Kinase Inhibitor, Reduces the Frequency of IL-4- and IL-10-, but Not IFN-γ-, Producing Murine CD4<sup>+</sup> and CD8<sup>+</sup> T Cells and Counteracts the Induction of Type 1 Regulatory T Cells
by: Agnieszka Jasiecka-Mikołajczyk, et al.
Published: (2021-09-01)

PD-1<sup>+</sup>CD8<sup>+</sup> T Cells Proximal to PD-L1<sup>+</sup>CD68<sup>+</sup> Macrophages Are Associated with Poor Prognosis in Pancreatic Ductal Adenocarcinoma Patients
by: Xiaobao Yang, et al.
Published: (2023-02-01)

CD34<sup>+</sup>CD10<sup>+</sup>CD19<sup>−</sup> Cells in Patients with Unhealthy Alcohol Use Stimulate the M2b Monocyte Polarization
by: Akira Asai, et al.
Published: (2022-08-01)

Characteristics of B-lymphocyte subpopulations in renal transplant recipients
by: S. V. Zybleva, et al.
Published: (2021-06-01)

Expression of CD40 and CD192 in Classical Monocytes in Multiple Sclerosis Patients Assessed with Transcranial Magnetic Stimulation
by: Nikolina Režić Mužinić, et al.
Published: (2023-10-01)

Reprogrammed CD8<sup>+</sup> T-Cells Isolated from the Mouse Spleen Increase the Number of Immune Cells with Antitumor Activity and Decrease the Amount of Cancer Stem Cells
by: Evgenii G. Skurikhin, et al.
Published: (2023-03-01)

Legend or Truth: Mature CD4<sup>+</sup>CD8<sup>+</sup> Double-Positive T Cells in the Periphery in Health and Disease
by: Magdalena Hagen, et al.
Published: (2023-10-01)

Opposing Roles of DCs and iNKT Cells in the Induction of Foxp3 Expression by MLN CD25<sup>+</sup>CD4<sup>+</sup> T Cells during IFNγ-Driven Colitis
by: Sung Won Lee, et al.
Published: (2022-12-01)

CD4<sup>+</sup>FOXP3<sup>+</sup> T Cells in Rheumatoid Arthritis Bone Marrow Are Partially Impaired
by: Magdalena Massalska, et al.
Published: (2020-02-01)

Immunohistological analysis of CD1a<sup> +</sup> langerhans cells and CD57<sup> +</sup> natural killer cells in healthy and diseased human gingival tissue: A comparative study
by: Stelin Sahaya, et al.
Published: (2009-01-01)

T Regulatory CD4<sup>+</sup>CD25<sup>+</sup>FoxP3<sup>+</sup> Lymphocytes in the Peripheral Blood of Left-Sided Colorectal Cancer Patients
by: Katarzyna Dylag-Trojanowska, et al.
Published: (2019-06-01)

Diacetyl Vapor Inhalation Induces Mixed, Granulocytic Lung Inflammation with Increased CD4<sup>+</sup>CD25<sup>+</sup> T Cells in the Rat
by: Emma L. House, et al.
Published: (2021-12-01)

ES-SCLC Patients with PD-L1<sup>+</sup> CTCs and High Percentages of CD8<sup>+</sup>PD-1<sup>+</sup>T Cells in Circulation Benefit from Front-Line Immunotherapy Treatment
by: Anastasia Xagara, et al.
Published: (2024-01-01)

Glutamate-Evoked Ca<sup>2+</sup> Responses in the Rat Suprachiasmatic Nucleus: Involvement of Na<sup>+</sup>/K<sup>+</sup>-ATPase and Na<sup>+</sup>/Ca<sup>2+</sup>-Exchanger
by: Pi-Cheng Cheng, et al.
Published: (2023-03-01)

Associations between NK Cells in Different Immune Organs and Cellular SIV DNA and RNA in Regional HLADR<sup>−</sup> CD4<sup>+</sup> T Cells in Chronically SIV<sub>mac239</sub>-Infected, Treatment-Naïve Rhesus Macaques
by: Xinjie Li, et al.
Published: (2022-11-01)

Effect of compound betamethasone on immunological rejection after xenogeneic corneal lamellar transplantation
by: Yan Cheng, et al.
Published: (2018-01-01)

Cytotoxic CD8<sup>+</sup> T cells and CD138<sup>+</sup> plasma cells prevail in cerebrospinal fluid in non-paraneoplastic cerebellar ataxia with contactin-associated protein-2 antibodies
by: Melzer Nico, et al.
Published: (2012-07-01)

Age-Associated Characteristics of CD4<sup>+</sup> T-Cell Composition in Patients with Atherosclerosis
by: Anastasiia Yu. Filatova, et al.
Published: (2021-08-01)

CD39-Expressing CD8<sup>+</sup> T Cells as a New Molecular Marker for Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma
by: Meitong Liu, et al.
Published: (2023-02-01)

Minor population of NK lymphocytes with CD19 coexpression
by: A. A. Kalashnikova, et al.
Published: (2024-04-01)

Comparative Study of Senescent Th Biomarkers in Healthy Donors and Early Arthritis Patients. Analysis of VPAC Receptors and Their Influence
by: Raúl Villanueva-Romero, et al.
Published: (2020-12-01)

Therapeutic Adenovirus Vaccine Combined Immunization with IL-12 Induces Potent CD8<sup>+</sup> T Cell Anti-Tumor Immunity in Hepatocellular Carcinoma
by: Yanyan Zheng, et al.
Published: (2022-09-01)

SARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity
by: Carola Amormino, et al.
Published: (2022-08-01)

Induction of CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cells from In Vitro Grown Human Mononuclear Cells by Sparteine Sulfate and Harpagoside
by: Nour Z. Atwany, et al.
Published: (2020-08-01)

Human CD4<sup>+</sup>CD45RA<sup>+</sup> T Cells Behavior after In Vitro Activation: Modulatory Role of Vasoactive Intestinal Peptide
by: Raúl Villanueva-Romero, et al.
Published: (2022-02-01)

Na<sup>+</sup>,K<sup>+</sup>-ATPase with Disrupted Na<sup>+</sup> Binding Sites I and III Binds Na<sup>+</sup> with Increased Affinity at Site II and Undergoes Na<sup>+</sup>-Activated Phosphorylation with ATP
by: Hang N. Nielsen, et al.
Published: (2024-01-01)

Accumulation of CD28<sup>null</sup> Senescent T-Cells Is Associated with Poorer Outcomes in COVID19 Patients
by: Mia J. Coleman, et al.
Published: (2021-09-01)

T Cells Immunophenotyping and CD38 Overexpression as Hallmarks of the Severity of COVID-19 and Predictors of Patients’ Outcomes
by: Nesrin I. Tarbiah, et al.
Published: (2023-01-01)

CD4<sup>+</sup> T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease
by: Yi-Hsing Chen, et al.
Published: (2021-09-01)

Compatible Stability and Aerosol Characteristics of Atrovent<sup>®</sup> (Ipratropium Bromide) Mixed with Salbutamol Sulfate, Terbutaline Sulfate, Budesonide, and Acetylcysteine
by: Yiting Chen, et al.
Published: (2020-08-01)

Recent advances in our understanding of human host responses to tuberculosis
by: Schluger Neil W
Published: (2001-03-01)