Impact of the progressive uptake of pneumococcal conjugate vaccines on the epidemiology and antimicrobial resistance of invasive pneumococcal disease in Gipuzkoa, northern Spain, 1998–2022
ObjectivesTo analyze the impact of pneumococcal conjugate vaccines (PCVs) on the incidence of invasive pneumococcal diseases (IPDs) and pneumococcal antibiotic resistance in Gipuzkoa, northern Spain for a 25 years period.MethodsAll cases of IPD confirmed by culture between 1998 and 2022 in a populat...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1238502/full |
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| author | Ayla Manzanal Ayla Manzanal Diego Vicente Diego Vicente Diego Vicente Marta Alonso Marta Alonso Nekane Azkue Maria Ercibengoa José María Marimón José María Marimón |
| author_facet | Ayla Manzanal Ayla Manzanal Diego Vicente Diego Vicente Diego Vicente Marta Alonso Marta Alonso Nekane Azkue Maria Ercibengoa José María Marimón José María Marimón |
| author_sort | Ayla Manzanal |
| collection | DOAJ |
| description | ObjectivesTo analyze the impact of pneumococcal conjugate vaccines (PCVs) on the incidence of invasive pneumococcal diseases (IPDs) and pneumococcal antibiotic resistance in Gipuzkoa, northern Spain for a 25 years period.MethodsAll cases of IPD confirmed by culture between 1998 and 2022 in a population of around 427,416 people were included. Pneumococci were serotyped and antimicrobial susceptibility was assessed by the EUCAST guidelines.ResultsOverall, 1,516 S. pneumoniae isolates were collected. Annual IPD incidence rates (per 100,000 people) declined from 19.9 in 1998–2001 to 11.5 in 2017–19 (42.2% reduction), especially in vaccinated children (from 46.7 to 24.9) and non-vaccinated older adult individuals (from 48.0 to 23.6). After PCV13 introduction, the decrease in the incidence of infections caused by PCV13 serotypes was balanced by the increase in the incidence of non-PCV13 serotypes. In the pandemic year of 2020, IPD incidence was the lowest: 2.81. The annual incidence rates of penicillin-resistant isolates also decreased, from 4.91 in 1998–2001 to 1.49 in 2017–19 and 0.70 in 2020. Since 2017, serotypes 14, 19A, and 11A have been the most common penicillin-resistant types. The incidence of erythromycin-resistant strains declined, from 3.65 to 1.73 and 0.70 in the same years.ConclusionPCV use was associated with declines in the incidence of IPD and the spread of non-vaccine serotypes, that balanced the beneficial effect off PCV13, some of them showing high rates of antibiotic resistance. |
| first_indexed | 2024-03-12T11:42:14Z |
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| id | doaj.art-101c5501b4ca4441abfb4c2b0be6b721 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-12T11:42:14Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-101c5501b4ca4441abfb4c2b0be6b7212023-08-31T13:45:02ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-08-011110.3389/fpubh.2023.12385021238502Impact of the progressive uptake of pneumococcal conjugate vaccines on the epidemiology and antimicrobial resistance of invasive pneumococcal disease in Gipuzkoa, northern Spain, 1998–2022Ayla Manzanal0Ayla Manzanal1Diego Vicente2Diego Vicente3Diego Vicente4Marta Alonso5Marta Alonso6Nekane Azkue7Maria Ercibengoa8José María Marimón9José María Marimón10Microbiology Department, Osakidetza Basque Health Service, Donostialdea Integrated Health Organization, San Sebastián, SpainDepartment of Preventive Medicine, University of the Basque Country (UPV/EHU), San Sebastián, SpainMicrobiology Department, Osakidetza Basque Health Service, Donostialdea Integrated Health Organization, San Sebastián, SpainDepartment of Preventive Medicine, University of the Basque Country (UPV/EHU), San Sebastián, SpainInfectious Diseases Area, Respiratory Infection and Antimicrobial Resistance Group, Biodonostia Health Research Institute, San Sebastián, SpainMicrobiology Department, Osakidetza Basque Health Service, Donostialdea Integrated Health Organization, San Sebastián, SpainInfectious Diseases Area, Respiratory Infection and Antimicrobial Resistance Group, Biodonostia Health Research Institute, San Sebastián, SpainMicrobiology Department, Osakidetza Basque Health Service, Donostialdea Integrated Health Organization, San Sebastián, SpainInfectious Diseases Area, Respiratory Infection and Antimicrobial Resistance Group, Biodonostia Health Research Institute, San Sebastián, SpainMicrobiology Department, Osakidetza Basque Health Service, Donostialdea Integrated Health Organization, San Sebastián, SpainInfectious Diseases Area, Respiratory Infection and Antimicrobial Resistance Group, Biodonostia Health Research Institute, San Sebastián, SpainObjectivesTo analyze the impact of pneumococcal conjugate vaccines (PCVs) on the incidence of invasive pneumococcal diseases (IPDs) and pneumococcal antibiotic resistance in Gipuzkoa, northern Spain for a 25 years period.MethodsAll cases of IPD confirmed by culture between 1998 and 2022 in a population of around 427,416 people were included. Pneumococci were serotyped and antimicrobial susceptibility was assessed by the EUCAST guidelines.ResultsOverall, 1,516 S. pneumoniae isolates were collected. Annual IPD incidence rates (per 100,000 people) declined from 19.9 in 1998–2001 to 11.5 in 2017–19 (42.2% reduction), especially in vaccinated children (from 46.7 to 24.9) and non-vaccinated older adult individuals (from 48.0 to 23.6). After PCV13 introduction, the decrease in the incidence of infections caused by PCV13 serotypes was balanced by the increase in the incidence of non-PCV13 serotypes. In the pandemic year of 2020, IPD incidence was the lowest: 2.81. The annual incidence rates of penicillin-resistant isolates also decreased, from 4.91 in 1998–2001 to 1.49 in 2017–19 and 0.70 in 2020. Since 2017, serotypes 14, 19A, and 11A have been the most common penicillin-resistant types. The incidence of erythromycin-resistant strains declined, from 3.65 to 1.73 and 0.70 in the same years.ConclusionPCV use was associated with declines in the incidence of IPD and the spread of non-vaccine serotypes, that balanced the beneficial effect off PCV13, some of them showing high rates of antibiotic resistance.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1238502/fullpneumococcal conjugate vaccinesinvasive pneumococcal diseasenon-vaccine serotypespneumococcal antibiotic resistanceSARS-CoV-2 preventive measures |
| spellingShingle | Ayla Manzanal Ayla Manzanal Diego Vicente Diego Vicente Diego Vicente Marta Alonso Marta Alonso Nekane Azkue Maria Ercibengoa José María Marimón José María Marimón Impact of the progressive uptake of pneumococcal conjugate vaccines on the epidemiology and antimicrobial resistance of invasive pneumococcal disease in Gipuzkoa, northern Spain, 1998–2022 Frontiers in Public Health pneumococcal conjugate vaccines invasive pneumococcal disease non-vaccine serotypes pneumococcal antibiotic resistance SARS-CoV-2 preventive measures |
| title | Impact of the progressive uptake of pneumococcal conjugate vaccines on the epidemiology and antimicrobial resistance of invasive pneumococcal disease in Gipuzkoa, northern Spain, 1998–2022 |
| title_full | Impact of the progressive uptake of pneumococcal conjugate vaccines on the epidemiology and antimicrobial resistance of invasive pneumococcal disease in Gipuzkoa, northern Spain, 1998–2022 |
| title_fullStr | Impact of the progressive uptake of pneumococcal conjugate vaccines on the epidemiology and antimicrobial resistance of invasive pneumococcal disease in Gipuzkoa, northern Spain, 1998–2022 |
| title_full_unstemmed | Impact of the progressive uptake of pneumococcal conjugate vaccines on the epidemiology and antimicrobial resistance of invasive pneumococcal disease in Gipuzkoa, northern Spain, 1998–2022 |
| title_short | Impact of the progressive uptake of pneumococcal conjugate vaccines on the epidemiology and antimicrobial resistance of invasive pneumococcal disease in Gipuzkoa, northern Spain, 1998–2022 |
| title_sort | impact of the progressive uptake of pneumococcal conjugate vaccines on the epidemiology and antimicrobial resistance of invasive pneumococcal disease in gipuzkoa northern spain 1998 2022 |
| topic | pneumococcal conjugate vaccines invasive pneumococcal disease non-vaccine serotypes pneumococcal antibiotic resistance SARS-CoV-2 preventive measures |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1238502/full |
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