Determination of some oxidative stress and inflammation markers in serum, blood and csf in cattle with head-eye form of malignant catarrhal fever
The aim of this study was to determine changes in total sialic acid (TSA), malondialdehyde (MDA), nitric oxide (NO), inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) levels on sera and CSF and reduced glutathione (GSH) levels on blood in cattle with Malignant Catar...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2017-07-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=2078 |
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| author | Ekin Emre ERKILIÇ Metin ÖĞÜN Ali Haydar KIRMIZIGÜL Yasemen ADALI Celal Şahin ERMUTLU Hüseyin Avni EROĞLU Abdulsamed KÜKÜRT Mehmet ÇİTİL Erdoğan UZLU |
| author_facet | Ekin Emre ERKILIÇ Metin ÖĞÜN Ali Haydar KIRMIZIGÜL Yasemen ADALI Celal Şahin ERMUTLU Hüseyin Avni EROĞLU Abdulsamed KÜKÜRT Mehmet ÇİTİL Erdoğan UZLU |
| author_sort | Ekin Emre ERKILIÇ |
| collection | DOAJ |
| description | The aim of this study was to determine changes in total sialic acid (TSA), malondialdehyde (MDA), nitric oxide (NO), inducible nitric oxide synthase (iNOS)
and endothelial nitric oxide synthase (eNOS) levels on sera and CSF and reduced glutathione (GSH) levels on blood in cattle with Malignant Catarrhal Fever
(MCF). For this purpose 17 cattle which clinically diagnosed "head-eye form" of MCF and clinically healthy 10 cattle were evaluated. Blood and cerebrospinal
fluid (CSF) were taken from the animals on the MCF diagnosed group MDA, GSH, NO, eNOS, iNOS, and TSA values were 25.65±0.42 µmol/L, 37.21±1.12
mg/dL, 30.61±0.41 µmol/L, 4.05±0.09 U/L and 10.98±0.35 U/L, 88.33±1.03 mg/dL, on the control group 13.77±0.55 µmol/L, 60.06±1.73 mg/dL, 11.27±0.4
µmol/L, 3.12±0.18 U/L, 5.55±0.3 U/L and 63.60±1.86 mg/dL respectively, and all parameter changes between the groups were determined to be statistically
significant (P<0.001). On the CSF, no statistically significant difference between taken from MCF diagnosed group and healthy group. NO value and iNOS
activity obtained from control groups CSF were relatively higher than the same group"s serum whereas eNOS activities were found to be low. The study group
consisting of MCF diagnosed cattle"s serum were found to have NO value, eNOS and iNOS activities relatively higher than the same group"s CSF values. As a
result, it was concluded that there is a need for more comprehensive studies for better understanding the reason of failure to obtain the significant changes
of animals diagnosed MCF that determine in blood but not in CSF. |
| first_indexed | 2024-03-13T04:36:57Z |
| format | Article |
| id | doaj.art-101c812bfd224ec2a98b700b6361959d |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:36:57Z |
| publishDate | 2017-07-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-101c812bfd224ec2a98b700b6361959d2023-06-19T06:45:25ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512017-07-0123451551910.9775/kvfd.2016.171662078Determination of some oxidative stress and inflammation markers in serum, blood and csf in cattle with head-eye form of malignant catarrhal feverEkin Emre ERKILIÇ0Metin ÖĞÜN1Ali Haydar KIRMIZIGÜL2Yasemen ADALI3Celal Şahin ERMUTLU4Hüseyin Avni EROĞLU5Abdulsamed KÜKÜRT6Mehmet ÇİTİL7Erdoğan UZLU8Kafkas Üniversitesi Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, TR-36100 Kars - TÜRKİYEKafkas Üniversitesi Veteriner Fakültesi, Biyokimya Anabilim Dalı, TR-36100 Kars - TÜRKİYEKafkas Üniversitesi Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, TR-36100 Kars - TÜRKİYEKafkas Üniversitesi Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı, TR-36100 Kars - TÜRKİYEKafkas Üniversitesi Veteriner Fakültesi, Cerrahi Anabilim Dalı, TR-36100 Kars - TÜRKİYEKafkas Üniversitesi Tıp Fakültesi, Fizyoloji Anabilim Dalı, TR-36100 Kars - TÜRKİYEKafkas Üniversitesi Veteriner Fakültesi, Biyokimya Anabilim Dalı, TR-36100 Kars - TÜRKİYEKafkas Üniversitesi Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, TR-36100 Kars - TÜRKİYEKafkas Üniversitesi Veteriner Fakültesi, İç Hastalıkları Anabilim Dalı, TR-36100 Kars - TÜRKİYEThe aim of this study was to determine changes in total sialic acid (TSA), malondialdehyde (MDA), nitric oxide (NO), inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) levels on sera and CSF and reduced glutathione (GSH) levels on blood in cattle with Malignant Catarrhal Fever (MCF). For this purpose 17 cattle which clinically diagnosed "head-eye form" of MCF and clinically healthy 10 cattle were evaluated. Blood and cerebrospinal fluid (CSF) were taken from the animals on the MCF diagnosed group MDA, GSH, NO, eNOS, iNOS, and TSA values were 25.65±0.42 µmol/L, 37.21±1.12 mg/dL, 30.61±0.41 µmol/L, 4.05±0.09 U/L and 10.98±0.35 U/L, 88.33±1.03 mg/dL, on the control group 13.77±0.55 µmol/L, 60.06±1.73 mg/dL, 11.27±0.4 µmol/L, 3.12±0.18 U/L, 5.55±0.3 U/L and 63.60±1.86 mg/dL respectively, and all parameter changes between the groups were determined to be statistically significant (P<0.001). On the CSF, no statistically significant difference between taken from MCF diagnosed group and healthy group. NO value and iNOS activity obtained from control groups CSF were relatively higher than the same group"s serum whereas eNOS activities were found to be low. The study group consisting of MCF diagnosed cattle"s serum were found to have NO value, eNOS and iNOS activities relatively higher than the same group"s CSF values. As a result, it was concluded that there is a need for more comprehensive studies for better understanding the reason of failure to obtain the significant changes of animals diagnosed MCF that determine in blood but not in CSF.https://vetdergikafkas.org/pdf.php?id=2078malignant catarrhal fevergshnitric oxideenosinoscattle |
| spellingShingle | Ekin Emre ERKILIÇ Metin ÖĞÜN Ali Haydar KIRMIZIGÜL Yasemen ADALI Celal Şahin ERMUTLU Hüseyin Avni EROĞLU Abdulsamed KÜKÜRT Mehmet ÇİTİL Erdoğan UZLU Determination of some oxidative stress and inflammation markers in serum, blood and csf in cattle with head-eye form of malignant catarrhal fever Kafkas Universitesi Veteriner Fakültesi Dergisi malignant catarrhal fever gsh nitric oxide enos inos cattle |
| title | Determination of some oxidative stress and inflammation markers in serum, blood and csf in cattle with head-eye form of malignant catarrhal fever |
| title_full | Determination of some oxidative stress and inflammation markers in serum, blood and csf in cattle with head-eye form of malignant catarrhal fever |
| title_fullStr | Determination of some oxidative stress and inflammation markers in serum, blood and csf in cattle with head-eye form of malignant catarrhal fever |
| title_full_unstemmed | Determination of some oxidative stress and inflammation markers in serum, blood and csf in cattle with head-eye form of malignant catarrhal fever |
| title_short | Determination of some oxidative stress and inflammation markers in serum, blood and csf in cattle with head-eye form of malignant catarrhal fever |
| title_sort | determination of some oxidative stress and inflammation markers in serum blood and csf in cattle with head eye form of malignant catarrhal fever |
| topic | malignant catarrhal fever gsh nitric oxide enos inos cattle |
| url | https://vetdergikafkas.org/pdf.php?id=2078 |
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