A translational approach to ventilator associated pneumonia
Abstract The management of Ventilator Associated Pneumonia (VAP) presents many difficulties because of the heterogeneity of the disease; the way the immunocompromised host and the aggressive ICU environment interact is only partially discovered, the available biomarkers for diagnosis are not suffici...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-12-01
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| Series: | Clinical and Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/2001-1326-3-26 |
| _version_ | 1819013795828203520 |
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| author | Ornella Piazza Xiangdong Wang |
| author_facet | Ornella Piazza Xiangdong Wang |
| author_sort | Ornella Piazza |
| collection | DOAJ |
| description | Abstract The management of Ventilator Associated Pneumonia (VAP) presents many difficulties because of the heterogeneity of the disease; the way the immunocompromised host and the aggressive ICU environment interact is only partially discovered, the available biomarkers for diagnosis are not sufficient to ensure prompt differentiation between sick patients and patients at risk, the microbiological cultures require invasive techniques and time consuming methods. A translational medicine and bio‐informatics approach can enable the identification of the main players of pathology, which may represent novel therapeutic targets or biomarker candidates. Analysis of proteome i.e. allows to individuate proteins that act as biomarkers, for patient‐centered research strategies. Similarly, the genomic approach has proved useful to individuate those patients who are prone to develop VAP, and, in the future, we could be able to immunomodulate their responses to save them from nosocomial infections. |
| first_indexed | 2024-12-21T02:05:38Z |
| format | Article |
| id | doaj.art-101d3d4cec74431fb106a05aced513a5 |
| institution | Directory Open Access Journal |
| issn | 2001-1326 |
| language | English |
| last_indexed | 2024-12-21T02:05:38Z |
| publishDate | 2014-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj.art-101d3d4cec74431fb106a05aced513a52022-12-21T19:19:30ZengWileyClinical and Translational Medicine2001-13262014-12-0131n/an/a10.1186/2001-1326-3-26A translational approach to ventilator associated pneumoniaOrnella Piazza0Xiangdong Wang1Università di SalernoBaronissi (SA)ItalyFudan UniversityShanghaiChinaAbstract The management of Ventilator Associated Pneumonia (VAP) presents many difficulties because of the heterogeneity of the disease; the way the immunocompromised host and the aggressive ICU environment interact is only partially discovered, the available biomarkers for diagnosis are not sufficient to ensure prompt differentiation between sick patients and patients at risk, the microbiological cultures require invasive techniques and time consuming methods. A translational medicine and bio‐informatics approach can enable the identification of the main players of pathology, which may represent novel therapeutic targets or biomarker candidates. Analysis of proteome i.e. allows to individuate proteins that act as biomarkers, for patient‐centered research strategies. Similarly, the genomic approach has proved useful to individuate those patients who are prone to develop VAP, and, in the future, we could be able to immunomodulate their responses to save them from nosocomial infections.https://doi.org/10.1186/2001-1326-3-26VAPTracheobronchitisBiomarkerssTREMProcalcitonin |
| spellingShingle | Ornella Piazza Xiangdong Wang A translational approach to ventilator associated pneumonia Clinical and Translational Medicine VAP Tracheobronchitis Biomarkers sTREM Procalcitonin |
| title | A translational approach to ventilator associated pneumonia |
| title_full | A translational approach to ventilator associated pneumonia |
| title_fullStr | A translational approach to ventilator associated pneumonia |
| title_full_unstemmed | A translational approach to ventilator associated pneumonia |
| title_short | A translational approach to ventilator associated pneumonia |
| title_sort | translational approach to ventilator associated pneumonia |
| topic | VAP Tracheobronchitis Biomarkers sTREM Procalcitonin |
| url | https://doi.org/10.1186/2001-1326-3-26 |
| work_keys_str_mv | AT ornellapiazza atranslationalapproachtoventilatorassociatedpneumonia AT xiangdongwang atranslationalapproachtoventilatorassociatedpneumonia AT ornellapiazza translationalapproachtoventilatorassociatedpneumonia AT xiangdongwang translationalapproachtoventilatorassociatedpneumonia |