Pathophysiology, Clinical, and Therapeutic Aspects of Narcolepsy
Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucination, and sleep paralysis. The exact cause remains unknown, but there is significant evidence that hypocretin deficiency plays an integral role. There have been advances in the under...
| Principais autores: | , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Psikiyatride Güncel Yaklaşımlar
2014-09-01
|
| coleção: | Psikiyatride Güncel Yaklaşımlar |
| Assuntos: | |
| Acesso em linha: | http://www.cappsy.org/archives/vol6/no3/cap_06_03_06.pdf |
| _version_ | 1827364377449201664 |
|---|---|
| author | Pinar Guzel Ozdemir Yavuz Selvi Tezay Cakin Gulec Mustafa Gulec |
| author_facet | Pinar Guzel Ozdemir Yavuz Selvi Tezay Cakin Gulec Mustafa Gulec |
| author_sort | Pinar Guzel Ozdemir |
| collection | DOAJ |
| description | Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucination, and sleep paralysis. The exact cause remains unknown, but there is significant evidence that hypocretin deficiency plays an integral role. There have been advances in the understanding of the pathogenesis of narcolepsy. It has a negative effect on the quality of life and can restrict the patients from certain careers and activities. Diagnosis relies on patient history and objective data gathered from polysomnography and multiple sleep latency testing. Treatment focuses on symptom relief through medication, education, and behavioral modification. Both classic pharmacological treatments as well as newer options have significant problems, especially because of side effects and abuse potential. Some novel modalities are being examined to expand options for treatment. In this review, the pathophysiological, clinical, and pharmacotherapeutic aspects of narcolepsy are discussed. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(3.000): 271-283] |
| first_indexed | 2024-03-08T08:08:08Z |
| format | Article |
| id | doaj.art-101e213e451549cfb35ee9d5be4f0c77 |
| institution | Directory Open Access Journal |
| issn | 1309-0658 |
| language | English |
| last_indexed | 2024-03-08T08:08:08Z |
| publishDate | 2014-09-01 |
| publisher | Psikiyatride Güncel Yaklaşımlar |
| record_format | Article |
| series | Psikiyatride Güncel Yaklaşımlar |
| spelling | doaj.art-101e213e451549cfb35ee9d5be4f0c772024-02-02T09:43:47ZengPsikiyatride Güncel YaklaşımlarPsikiyatride Güncel Yaklaşımlar1309-06582014-09-016327128310.5455/cap.20140115073522149657Pathophysiology, Clinical, and Therapeutic Aspects of NarcolepsyPinar Guzel Ozdemir0Yavuz Selvi1Tezay Cakin Gulec2Mustafa Gulec3Yuzuncu Yil Universitesi Tip Fakultesi, Psikiyatri Anabilimdali Selcuk Universitesi Tip Fakultesi, Psikiyatri Anabilimdali, SUSAB (Sinirbilim Arastirma) Turkan Ozilhan Bornova Devlet Hastanesi Noroloji Klinigi izmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma Hastanesi Psikiyatri KlinigiNarcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucination, and sleep paralysis. The exact cause remains unknown, but there is significant evidence that hypocretin deficiency plays an integral role. There have been advances in the understanding of the pathogenesis of narcolepsy. It has a negative effect on the quality of life and can restrict the patients from certain careers and activities. Diagnosis relies on patient history and objective data gathered from polysomnography and multiple sleep latency testing. Treatment focuses on symptom relief through medication, education, and behavioral modification. Both classic pharmacological treatments as well as newer options have significant problems, especially because of side effects and abuse potential. Some novel modalities are being examined to expand options for treatment. In this review, the pathophysiological, clinical, and pharmacotherapeutic aspects of narcolepsy are discussed. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(3.000): 271-283]http://www.cappsy.org/archives/vol6/no3/cap_06_03_06.pdfNarcolepsy; Cataplexy; Hypocretin; Treatment |
| spellingShingle | Pinar Guzel Ozdemir Yavuz Selvi Tezay Cakin Gulec Mustafa Gulec Pathophysiology, Clinical, and Therapeutic Aspects of Narcolepsy Psikiyatride Güncel Yaklaşımlar Narcolepsy; Cataplexy; Hypocretin; Treatment |
| title | Pathophysiology, Clinical, and Therapeutic Aspects of Narcolepsy |
| title_full | Pathophysiology, Clinical, and Therapeutic Aspects of Narcolepsy |
| title_fullStr | Pathophysiology, Clinical, and Therapeutic Aspects of Narcolepsy |
| title_full_unstemmed | Pathophysiology, Clinical, and Therapeutic Aspects of Narcolepsy |
| title_short | Pathophysiology, Clinical, and Therapeutic Aspects of Narcolepsy |
| title_sort | pathophysiology clinical and therapeutic aspects of narcolepsy |
| topic | Narcolepsy; Cataplexy; Hypocretin; Treatment |
| url | http://www.cappsy.org/archives/vol6/no3/cap_06_03_06.pdf |
| work_keys_str_mv | AT pinarguzelozdemir pathophysiologyclinicalandtherapeuticaspectsofnarcolepsy AT yavuzselvi pathophysiologyclinicalandtherapeuticaspectsofnarcolepsy AT tezaycakingulec pathophysiologyclinicalandtherapeuticaspectsofnarcolepsy AT mustafagulec pathophysiologyclinicalandtherapeuticaspectsofnarcolepsy |