Association of vaccination status with the clinicobiochemical profile, hospital stay, and mortality in COVID‐19: A case–control study
Abstract Background and Aims The effectiveness of coronavirus disease 2019 (COVID‐19) vaccines in reducing symptoms, disease advancement, complications, and mortality in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has been well‐established. This case‐control study aimed to...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
|
| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.1579 |
| _version_ | 1797672468043792384 |
|---|---|
| author | Sangam Shah Kiran Paudel Abhinav Bhattarai Sangharsha Thapa Sandesh Bhusal Yagya R. Adhikari Tara B. Adhikari Nikita Bhatta Prince Mandal Pratima Sharma Bishal Budha Shova Aryal Santa K. Das Pankaj Pant |
| author_facet | Sangam Shah Kiran Paudel Abhinav Bhattarai Sangharsha Thapa Sandesh Bhusal Yagya R. Adhikari Tara B. Adhikari Nikita Bhatta Prince Mandal Pratima Sharma Bishal Budha Shova Aryal Santa K. Das Pankaj Pant |
| author_sort | Sangam Shah |
| collection | DOAJ |
| description | Abstract Background and Aims The effectiveness of coronavirus disease 2019 (COVID‐19) vaccines in reducing symptoms, disease advancement, complications, and mortality in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has been well‐established. This case‐control study aimed to compare different blood parameters, and prognostic and survival outcomes of COVID‐19 patients based on vaccination status. Methods We performed a case‐control study that included hospitalized patients with COVID‐19 at Tribhuvan University Teaching Hospital, Kathmandu, Nepal. Individuals who received vaccination were designated as cases and unvaccinated individuals as controls. Demographics, co‐morbidity, clinical data, laboratory data, and disease outcomes were recorded for both groups. Multivariate, Cox, and linear regression were used for analysing blood parameters, hospital admission, survival, and hospital stay, respectively, between cases and controls. Results Out of 100 participants enrolled, 46 were vaccinated, and 54 weren't. At admission, ferritin and erythrocyte sedimentation rate (ESR) were significantly lower in cases. At discharge, cases showed a higher monocyte than controls. Ferritin, ESR, and d‐imer showed excellent performance in determining the severity of symptoms. Significant correlation and regression of ferritin and ESR with the length of hospital stay was observed. Length of hospital stay was significantly lower in cases than in controls. No significant differences between cases and controls were observed in mortality. Conclusion COVID‐19 vaccines effectively reduced hospitalization duration. Ferritin and ESR were significantly lower in vaccinated individuals and showed the best utility in monitoring the disease. |
| first_indexed | 2024-03-11T21:30:30Z |
| format | Article |
| id | doaj.art-1021e5cd407c499ca8e186cb13201850 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-11T21:30:30Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-1021e5cd407c499ca8e186cb132018502023-09-27T09:16:35ZengWileyHealth Science Reports2398-88352023-09-0169n/an/a10.1002/hsr2.1579Association of vaccination status with the clinicobiochemical profile, hospital stay, and mortality in COVID‐19: A case–control studySangam Shah0Kiran Paudel1Abhinav Bhattarai2Sangharsha Thapa3Sandesh Bhusal4Yagya R. Adhikari5Tara B. Adhikari6Nikita Bhatta7Prince Mandal8Pratima Sharma9Bishal Budha10Shova Aryal11Santa K. Das12Pankaj Pant13Institute of Medicine Tribhuvan University Maharajgunj NepalNepal Health Frontiers Kathmandu Tokha NepalInstitute of Medicine Tribhuvan University Maharajgunj NepalWestchester Medical Center New York USANepal Health Frontiers Kathmandu Tokha NepalInstitute of Medicine Tribhuvan University Maharajgunj NepalNepal Health Frontiers Kathmandu Tokha NepalInstitute of Medicine Tribhuvan University Maharajgunj NepalInstitute of Medicine Tribhuvan University Maharajgunj NepalInstitute of Medicine Tribhuvan University Maharajgunj NepalInstitute of Medicine Tribhuvan University Maharajgunj NepalInstitute of Medicine Tribhuvan University Maharajgunj NepalDepartment of Pulmonology and Critical Care, Institute of Medicine Tribhuvan University Maharajgunj NepalDepartment of Pulmonology and Critical Care, Institute of Medicine Tribhuvan University Maharajgunj NepalAbstract Background and Aims The effectiveness of coronavirus disease 2019 (COVID‐19) vaccines in reducing symptoms, disease advancement, complications, and mortality in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has been well‐established. This case‐control study aimed to compare different blood parameters, and prognostic and survival outcomes of COVID‐19 patients based on vaccination status. Methods We performed a case‐control study that included hospitalized patients with COVID‐19 at Tribhuvan University Teaching Hospital, Kathmandu, Nepal. Individuals who received vaccination were designated as cases and unvaccinated individuals as controls. Demographics, co‐morbidity, clinical data, laboratory data, and disease outcomes were recorded for both groups. Multivariate, Cox, and linear regression were used for analysing blood parameters, hospital admission, survival, and hospital stay, respectively, between cases and controls. Results Out of 100 participants enrolled, 46 were vaccinated, and 54 weren't. At admission, ferritin and erythrocyte sedimentation rate (ESR) were significantly lower in cases. At discharge, cases showed a higher monocyte than controls. Ferritin, ESR, and d‐imer showed excellent performance in determining the severity of symptoms. Significant correlation and regression of ferritin and ESR with the length of hospital stay was observed. Length of hospital stay was significantly lower in cases than in controls. No significant differences between cases and controls were observed in mortality. Conclusion COVID‐19 vaccines effectively reduced hospitalization duration. Ferritin and ESR were significantly lower in vaccinated individuals and showed the best utility in monitoring the disease.https://doi.org/10.1002/hsr2.1579COVID‐19EffectivenessNepalVCaccines |
| spellingShingle | Sangam Shah Kiran Paudel Abhinav Bhattarai Sangharsha Thapa Sandesh Bhusal Yagya R. Adhikari Tara B. Adhikari Nikita Bhatta Prince Mandal Pratima Sharma Bishal Budha Shova Aryal Santa K. Das Pankaj Pant Association of vaccination status with the clinicobiochemical profile, hospital stay, and mortality in COVID‐19: A case–control study Health Science Reports COVID‐19 Effectiveness Nepal VCaccines |
| title | Association of vaccination status with the clinicobiochemical profile, hospital stay, and mortality in COVID‐19: A case–control study |
| title_full | Association of vaccination status with the clinicobiochemical profile, hospital stay, and mortality in COVID‐19: A case–control study |
| title_fullStr | Association of vaccination status with the clinicobiochemical profile, hospital stay, and mortality in COVID‐19: A case–control study |
| title_full_unstemmed | Association of vaccination status with the clinicobiochemical profile, hospital stay, and mortality in COVID‐19: A case–control study |
| title_short | Association of vaccination status with the clinicobiochemical profile, hospital stay, and mortality in COVID‐19: A case–control study |
| title_sort | association of vaccination status with the clinicobiochemical profile hospital stay and mortality in covid 19 a case control study |
| topic | COVID‐19 Effectiveness Nepal VCaccines |
| url | https://doi.org/10.1002/hsr2.1579 |
| work_keys_str_mv | AT sangamshah associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT kiranpaudel associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT abhinavbhattarai associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT sangharshathapa associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT sandeshbhusal associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT yagyaradhikari associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT tarabadhikari associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT nikitabhatta associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT princemandal associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT pratimasharma associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT bishalbudha associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT shovaaryal associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT santakdas associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy AT pankajpant associationofvaccinationstatuswiththeclinicobiochemicalprofilehospitalstayandmortalityincovid19acasecontrolstudy |