Antihyperglycemic efficacy and safety of AKROPOL, a Persian medicine poly-herbal extract mixture, in the treatment of type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial
Background: In Iran, a variety of medicinal plants are used, either alone or in combination, for the treatment of diabetes mellitus (DM). However, scientific and clinical studies are needed to confirm the safety and efficacy of these medicinal plants. Objective: To evaluate the safety and efficacy o...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2023-05-01
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| Series: | Journal of Medicinal Plants |
| Subjects: | |
| Online Access: | http://jmp.ir/article-1-3438-en.pdf |
| _version_ | 1797645545357967360 |
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| author | Hasan Fallah Huseini Khalil Mohamadzadeh Saeed Kianbakht Sayed Mohammad Mohammadi Maryam Ahvazi Mahboobeh Sadat Hooseini Nahid Khalili Behzad Foroutan Mehdi Saberi Amir Baghaei Reza Mohtashami |
| author_facet | Hasan Fallah Huseini Khalil Mohamadzadeh Saeed Kianbakht Sayed Mohammad Mohammadi Maryam Ahvazi Mahboobeh Sadat Hooseini Nahid Khalili Behzad Foroutan Mehdi Saberi Amir Baghaei Reza Mohtashami |
| author_sort | Hasan Fallah Huseini |
| collection | DOAJ |
| description | Background: In Iran, a variety of medicinal plants are used, either alone or in combination, for the treatment of diabetes mellitus (DM). However, scientific and clinical studies are needed to confirm the safety and efficacy of these medicinal plants. Objective: To evaluate the safety and efficacy of AKROPOL, a poly-herbal extract mixture used in Persian medicine, in the treatment of type 2 diabetic patients. Methods: Eighty six male and female patients, aged 40-60 years, registered at the Diabetes Clinic Registry of the Baqiyatallah Hospital, in Tehran, Iran, randomly allocated to two groups of 43 each. The patients in AKROPOL group received one capsule (containing 500 mg of poly-herbal extract mixture: chicory, turmeric, nettle, fenugreek and whortleberry) and the patients in placebo group received one capsule (containing 500 mg toast powder) twice a day in addition to their routine anti-diabetic medications for 3 months. The primary outcome measures were HbA1C and FBG (fasting blood glucose) levels, while lipid levels, liver enzymes and renal function tests were secondary outcome measures. Results: Compared with the placebo group and baseline, the AKROPOL group showed significant reductions in FBG, HbA1C, total cholesterol, and LDL-C levels. No significant hepatic, renal, gastrointestinal, or other side effects were observed during the study. Conclusion: The findings suggest that AKROPOL in addition to anti-diabetic and cholesterol-lowering effects, had no adverse effects in type 2 diabetic patients. |
| first_indexed | 2024-03-11T14:48:22Z |
| format | Article |
| id | doaj.art-10225a62573e4285a49fff0be8454244 |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-03-11T14:48:22Z |
| publishDate | 2023-05-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-10225a62573e4285a49fff0be84542442023-10-30T10:28:48ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582023-05-012286113Antihyperglycemic efficacy and safety of AKROPOL, a Persian medicine poly-herbal extract mixture, in the treatment of type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trialHasan Fallah Huseini0Khalil Mohamadzadeh1Saeed Kianbakht2Sayed Mohammad Mohammadi3Maryam Ahvazi4Mahboobeh Sadat Hooseini5Nahid Khalili6Behzad Foroutan7Mehdi Saberi8Amir Baghaei9Reza Mohtashami10 Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Department of Internal Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran Tropical and Communicable Diseases Research Center, Iranshahr University of Medical Sciences, Iranshahr, Iran; Department of Pharmacology, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran Department of Pharmacology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran Department of Toxicology and Pharmacology, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran Medicine, Quran, and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Background: In Iran, a variety of medicinal plants are used, either alone or in combination, for the treatment of diabetes mellitus (DM). However, scientific and clinical studies are needed to confirm the safety and efficacy of these medicinal plants. Objective: To evaluate the safety and efficacy of AKROPOL, a poly-herbal extract mixture used in Persian medicine, in the treatment of type 2 diabetic patients. Methods: Eighty six male and female patients, aged 40-60 years, registered at the Diabetes Clinic Registry of the Baqiyatallah Hospital, in Tehran, Iran, randomly allocated to two groups of 43 each. The patients in AKROPOL group received one capsule (containing 500 mg of poly-herbal extract mixture: chicory, turmeric, nettle, fenugreek and whortleberry) and the patients in placebo group received one capsule (containing 500 mg toast powder) twice a day in addition to their routine anti-diabetic medications for 3 months. The primary outcome measures were HbA1C and FBG (fasting blood glucose) levels, while lipid levels, liver enzymes and renal function tests were secondary outcome measures. Results: Compared with the placebo group and baseline, the AKROPOL group showed significant reductions in FBG, HbA1C, total cholesterol, and LDL-C levels. No significant hepatic, renal, gastrointestinal, or other side effects were observed during the study. Conclusion: The findings suggest that AKROPOL in addition to anti-diabetic and cholesterol-lowering effects, had no adverse effects in type 2 diabetic patients.http://jmp.ir/article-1-3438-en.pdftype 2 diabetespersian medicineclinical trialakropolherbal medicine |
| spellingShingle | Hasan Fallah Huseini Khalil Mohamadzadeh Saeed Kianbakht Sayed Mohammad Mohammadi Maryam Ahvazi Mahboobeh Sadat Hooseini Nahid Khalili Behzad Foroutan Mehdi Saberi Amir Baghaei Reza Mohtashami Antihyperglycemic efficacy and safety of AKROPOL, a Persian medicine poly-herbal extract mixture, in the treatment of type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial Journal of Medicinal Plants type 2 diabetes persian medicine clinical trial akropol herbal medicine |
| title | Antihyperglycemic efficacy and safety of AKROPOL, a Persian medicine poly-herbal extract mixture, in the treatment of type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial |
| title_full | Antihyperglycemic efficacy and safety of AKROPOL, a Persian medicine poly-herbal extract mixture, in the treatment of type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial |
| title_fullStr | Antihyperglycemic efficacy and safety of AKROPOL, a Persian medicine poly-herbal extract mixture, in the treatment of type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial |
| title_full_unstemmed | Antihyperglycemic efficacy and safety of AKROPOL, a Persian medicine poly-herbal extract mixture, in the treatment of type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial |
| title_short | Antihyperglycemic efficacy and safety of AKROPOL, a Persian medicine poly-herbal extract mixture, in the treatment of type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial |
| title_sort | antihyperglycemic efficacy and safety of akropol a persian medicine poly herbal extract mixture in the treatment of type 2 diabetic patients a randomized double blind and placebo controlled clinical trial |
| topic | type 2 diabetes persian medicine clinical trial akropol herbal medicine |
| url | http://jmp.ir/article-1-3438-en.pdf |
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