Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies

Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies

Abstract Background Point mutations in histone variant H3.3 (H3.3K27M, H3.3G34R) and the H3.3-specific ATRX/DAXX chaperone complex are frequent events in pediatric gliomas. These H3.3 point mutations affect many chromatin modifications but the exact oncogenic mechanisms are currently unclear. Histon...

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Bibliographic Details
Main Authors: Hsiao P. J. Voon, Linda Hii, Andrew Garvie, Maheshi Udugama, Brian Krug, Caterina Russo, Anderly C. Chüeh, Roger J. Daly, Alison Morey, Toby D. M. Bell, Stephen J. Turner, Joseph Rosenbluh, Paul Daniel, Ron Firestein, Jeffrey R. Mann, Philippe Collas, Nada Jabado, Lee H. Wong
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Genome Biology
Subjects:
Histone variant H3.3
Pediatric glioma
PML bodies
Arsenic trioxide
Online Access:https://doi.org/10.1186/s13059-023-03122-5

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