Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons

Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons

Decreased rRNA synthesis and nucleolar disruption, known as nucleolar stress, are primary signs of cellular stress associated with aging and neurodegenerative disorders. Silencing of rDNA occurs during early stages of Alzheimer´s disease (AD) and may play a role in dementia. Moreover aberra...

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Bibliographic Details
Main Authors: Anna eKiryk, Grzegorz eKreiner, Katharina eSowodniok, Jan eRodriguez-Parkitna, Aynur eSoenmez, Tomasz eGórkiewicz, Holger eBierhoff, Marcin eWawrzyniak, Artur K Janusz, Birgit eLiss, Witold eKonopka, Günther eSchütz, Leszek eKaczmarek, Rosanna eParlato
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Hippocampus
Neurogenesis
learning and memory
rRNA
mTOR
nucleolus
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00207/full

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