Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications
The dopaminergic system can adapt to the different physiological or pathological situations to which the kidneys are subjected throughout life, maintaining homeostasis of natriuresis, extracellular volume, and blood pressure levels. The role of renal dopamine receptor dysfunction is clearly establis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/2/254 |
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| author | Alejandro Olivares-Hernández Luis Figuero-Pérez Juan Jesus Cruz-Hernandez Rogelio González Sarmiento Ricardo Usategui-Martin José Pablo Miramontes-González |
| author_facet | Alejandro Olivares-Hernández Luis Figuero-Pérez Juan Jesus Cruz-Hernandez Rogelio González Sarmiento Ricardo Usategui-Martin José Pablo Miramontes-González |
| author_sort | Alejandro Olivares-Hernández |
| collection | DOAJ |
| description | The dopaminergic system can adapt to the different physiological or pathological situations to which the kidneys are subjected throughout life, maintaining homeostasis of natriuresis, extracellular volume, and blood pressure levels. The role of renal dopamine receptor dysfunction is clearly established in the pathogenesis of essential hypertension. Its associations with other pathological states such as insulin resistance and redox balance have also been associated with dysfunction of the dopaminergic system. The different dopamine receptors (D1–D5) show a protective effect against hypertension and kidney disorders. It is essential to take into account the various interactions of the dopaminergic system with other elements, such as adrenergic receptors. The approach to therapeutic strategies for essential hypertension must go through the blocking of those elements that lead to renal vasoconstriction or the restoration of the normal functioning of dopamine receptors. D1-like receptors are fundamental in this role, and new therapeutic efforts should be directed to the restoration of their functioning in many patients. More studies will be needed to allow the development of drugs that can be targeted to renal dopamine receptors in the treatment of hypertension. |
| first_indexed | 2024-03-09T04:51:37Z |
| format | Article |
| id | doaj.art-1025ce114e2949948a66d7de3d801455 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T04:51:37Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-1025ce114e2949948a66d7de3d8014552023-12-03T13:09:52ZengMDPI AGBiomolecules2218-273X2021-02-0111225410.3390/biom11020254Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted ImplicationsAlejandro Olivares-Hernández0Luis Figuero-Pérez1Juan Jesus Cruz-Hernandez2Rogelio González Sarmiento3Ricardo Usategui-Martin4José Pablo Miramontes-González5Department of Medical Oncology, University Hospital of Salamanca, 37007 Salamanca, SpainDepartment of Medical Oncology, University Hospital of Salamanca, 37007 Salamanca, SpainInstitute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, SpainInstitute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, SpainIOBA, Universidad de Valladolid, 47011 Valladolid, SpainInstitute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, SpainThe dopaminergic system can adapt to the different physiological or pathological situations to which the kidneys are subjected throughout life, maintaining homeostasis of natriuresis, extracellular volume, and blood pressure levels. The role of renal dopamine receptor dysfunction is clearly established in the pathogenesis of essential hypertension. Its associations with other pathological states such as insulin resistance and redox balance have also been associated with dysfunction of the dopaminergic system. The different dopamine receptors (D1–D5) show a protective effect against hypertension and kidney disorders. It is essential to take into account the various interactions of the dopaminergic system with other elements, such as adrenergic receptors. The approach to therapeutic strategies for essential hypertension must go through the blocking of those elements that lead to renal vasoconstriction or the restoration of the normal functioning of dopamine receptors. D1-like receptors are fundamental in this role, and new therapeutic efforts should be directed to the restoration of their functioning in many patients. More studies will be needed to allow the development of drugs that can be targeted to renal dopamine receptors in the treatment of hypertension.https://www.mdpi.com/2218-273X/11/2/254dopaminekidneyhypertension |
| spellingShingle | Alejandro Olivares-Hernández Luis Figuero-Pérez Juan Jesus Cruz-Hernandez Rogelio González Sarmiento Ricardo Usategui-Martin José Pablo Miramontes-González Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications Biomolecules dopamine kidney hypertension |
| title | Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications |
| title_full | Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications |
| title_fullStr | Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications |
| title_full_unstemmed | Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications |
| title_short | Dopamine Receptors and the Kidney: An Overview of Health- and Pharmacological-Targeted Implications |
| title_sort | dopamine receptors and the kidney an overview of health and pharmacological targeted implications |
| topic | dopamine kidney hypertension |
| url | https://www.mdpi.com/2218-273X/11/2/254 |
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