Sodium butyrate inhibits osteogenesis in human periodontal ligament stem cells by suppressing smad1 expression

Sodium butyrate inhibits osteogenesis in human periodontal ligament stem cells by suppressing smad1 expression

Abstract Background Butyrate is a major subgingival microbial metabolite that is closely related to periodontal disease. It affects the proliferation and differentiation of mesenchymal stem cells. However, the mechanisms by which butyrate affects the osteogenic differentiation of periodontal ligamen...

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Bibliographic Details
Main Authors: Jingyi Hou, Junji Xu, Yi Liu, Haiping Zhang, Sihan Wang, Yao Jiao, Lijia Guo, Song Li
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Oral Health
Subjects:
Sodium butyrate
Periodontal ligament stem cells
Proliferation
Osteogenic differentiation
Smad1
Free fatty acids receptor 2
Online Access:https://doi.org/10.1186/s12903-022-02255-6

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