Serological evidence of Zika virus infection in febrile patients at Greater Accra Regional Hospital, Accra Ghana
Abstract Objective Increase in the evidence of global occurrence of Zika viral infection suggests that in Africa the circulation of the virus which causes 80% of asymptomatic infection could be undetected and/or overlooked. We sought to serologically detect Zika virus infection in febrile patients a...
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BMC
2019-06-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-019-4371-4 |
| _version_ | 1818524132489297920 |
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| author | Godson Aryee Ankrah Joseph Humphrey Kofi Bonney Esinam Eudosia Agbosu Deborah Pratt Theophilus Korku Adiku |
| author_facet | Godson Aryee Ankrah Joseph Humphrey Kofi Bonney Esinam Eudosia Agbosu Deborah Pratt Theophilus Korku Adiku |
| author_sort | Godson Aryee Ankrah |
| collection | DOAJ |
| description | Abstract Objective Increase in the evidence of global occurrence of Zika viral infection suggests that in Africa the circulation of the virus which causes 80% of asymptomatic infection could be undetected and/or overlooked. We sought to serologically detect Zika virus infection in febrile patients at Greater Accra Regional Hospital, Ghana. Results Of the 160 patient serum samples analyzed, 33 were found to have antibodies against Zika virus infection. Among the sero-positives 30 (91%) of the cases were anti-Zika virus IgM with the 21–30-year age group recording the highest number of 8 (26%) and 2 (7%) cases being the least for the 61 years and above age group. All sero-positive febrile patients developed at least one symptom consistent with Zika virus infection: 33 (100%) fever, 25 (76%) muscle pain, 24 (73%) joint pain, and conjunctivitis 2 (6%). Digestive symptoms recorded include 16 (49%) nausea, 12 (36%) vomiting and diarrhea 18 (55%). In addition, 28 (85%) loss of appetite, 14 (75%) rapid respiration and chest pain 15 (42%) were reported by seropositive febrile patients. Our data indicates exposure to Zika virus which suggests the possible circulation of the virus among febrile patients in Ghana with a sero-prevalence rate of 20.6%. |
| first_indexed | 2024-12-11T05:53:22Z |
| format | Article |
| id | doaj.art-102a0c1328924380a16f991f2160eb4c |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-11T05:53:22Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-102a0c1328924380a16f991f2160eb4c2022-12-22T01:18:45ZengBMCBMC Research Notes1756-05002019-06-011211510.1186/s13104-019-4371-4Serological evidence of Zika virus infection in febrile patients at Greater Accra Regional Hospital, Accra GhanaGodson Aryee Ankrah0Joseph Humphrey Kofi Bonney1Esinam Eudosia Agbosu2Deborah Pratt3Theophilus Korku Adiku4Department of Medical Microbiology, College of Health Sciences, University of GhanaVirology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaVirology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaVirology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartment of Medical Microbiology, College of Health Sciences, University of GhanaAbstract Objective Increase in the evidence of global occurrence of Zika viral infection suggests that in Africa the circulation of the virus which causes 80% of asymptomatic infection could be undetected and/or overlooked. We sought to serologically detect Zika virus infection in febrile patients at Greater Accra Regional Hospital, Ghana. Results Of the 160 patient serum samples analyzed, 33 were found to have antibodies against Zika virus infection. Among the sero-positives 30 (91%) of the cases were anti-Zika virus IgM with the 21–30-year age group recording the highest number of 8 (26%) and 2 (7%) cases being the least for the 61 years and above age group. All sero-positive febrile patients developed at least one symptom consistent with Zika virus infection: 33 (100%) fever, 25 (76%) muscle pain, 24 (73%) joint pain, and conjunctivitis 2 (6%). Digestive symptoms recorded include 16 (49%) nausea, 12 (36%) vomiting and diarrhea 18 (55%). In addition, 28 (85%) loss of appetite, 14 (75%) rapid respiration and chest pain 15 (42%) were reported by seropositive febrile patients. Our data indicates exposure to Zika virus which suggests the possible circulation of the virus among febrile patients in Ghana with a sero-prevalence rate of 20.6%.http://link.springer.com/article/10.1186/s13104-019-4371-4Zika virusSeroprevalenceAnti-Zika virus immunoglobulins M and G (IgM and IgG) antibodiesEnzyme linked immunosorbent assay (ELISA) |
| spellingShingle | Godson Aryee Ankrah Joseph Humphrey Kofi Bonney Esinam Eudosia Agbosu Deborah Pratt Theophilus Korku Adiku Serological evidence of Zika virus infection in febrile patients at Greater Accra Regional Hospital, Accra Ghana BMC Research Notes Zika virus Seroprevalence Anti-Zika virus immunoglobulins M and G (IgM and IgG) antibodies Enzyme linked immunosorbent assay (ELISA) |
| title | Serological evidence of Zika virus infection in febrile patients at Greater Accra Regional Hospital, Accra Ghana |
| title_full | Serological evidence of Zika virus infection in febrile patients at Greater Accra Regional Hospital, Accra Ghana |
| title_fullStr | Serological evidence of Zika virus infection in febrile patients at Greater Accra Regional Hospital, Accra Ghana |
| title_full_unstemmed | Serological evidence of Zika virus infection in febrile patients at Greater Accra Regional Hospital, Accra Ghana |
| title_short | Serological evidence of Zika virus infection in febrile patients at Greater Accra Regional Hospital, Accra Ghana |
| title_sort | serological evidence of zika virus infection in febrile patients at greater accra regional hospital accra ghana |
| topic | Zika virus Seroprevalence Anti-Zika virus immunoglobulins M and G (IgM and IgG) antibodies Enzyme linked immunosorbent assay (ELISA) |
| url | http://link.springer.com/article/10.1186/s13104-019-4371-4 |
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