Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy
Emerging and re-emerging viruses have been a challenge in public health in recent decades. Host-targeted antivirals (HTA) directed at cellular molecules or pathways involved in virus multiplication represent an interesting strategy to combat viruses presently lacking effective chemotherapy. HTA coul...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/8/1631 |
| _version_ | 1827598946629844992 |
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| author | Claudia Soledad Sepúlveda Cybele Carina García Elsa Beatriz Damonte |
| author_facet | Claudia Soledad Sepúlveda Cybele Carina García Elsa Beatriz Damonte |
| author_sort | Claudia Soledad Sepúlveda |
| collection | DOAJ |
| description | Emerging and re-emerging viruses have been a challenge in public health in recent decades. Host-targeted antivirals (HTA) directed at cellular molecules or pathways involved in virus multiplication represent an interesting strategy to combat viruses presently lacking effective chemotherapy. HTA could provide a wide range of agents with inhibitory activity against current and future viruses that share similar host requirements and reduce the possible selection of antiviral-resistant variants. Nucleotide metabolism is one of the more exploited host metabolic pathways as a potential antiviral target for several human viruses. This review focuses on the antiviral properties of the inhibitors of pyrimidine and purine nucleotide biosynthesis, with an emphasis on the rate-limiting enzymes dihydroorotate dehydrogenase (DHODH) and inosine monophosphate dehydrogenase (IMPDH) for which there are old and new drugs active against a broad spectrum of pathogenic viruses. |
| first_indexed | 2024-03-09T04:03:12Z |
| format | Article |
| id | doaj.art-102aa6419fad4a04aacbf1c2f15afaa5 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T04:03:12Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-102aa6419fad4a04aacbf1c2f15afaa52023-12-03T14:09:37ZengMDPI AGMicroorganisms2076-26072022-08-01108163110.3390/microorganisms10081631Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral ChemotherapyClaudia Soledad Sepúlveda0Cybele Carina García1Elsa Beatriz Damonte2Laboratory of Virology, Biochemistry Department, School of Sciences, University of Buenos Aires (UBA), Ciudad Universitaria, Buenos Aires 1428, ArgentinaLaboratory of Virology, Biochemistry Department, School of Sciences, University of Buenos Aires (UBA), Ciudad Universitaria, Buenos Aires 1428, ArgentinaLaboratory of Virology, Biochemistry Department, School of Sciences, University of Buenos Aires (UBA), Ciudad Universitaria, Buenos Aires 1428, ArgentinaEmerging and re-emerging viruses have been a challenge in public health in recent decades. Host-targeted antivirals (HTA) directed at cellular molecules or pathways involved in virus multiplication represent an interesting strategy to combat viruses presently lacking effective chemotherapy. HTA could provide a wide range of agents with inhibitory activity against current and future viruses that share similar host requirements and reduce the possible selection of antiviral-resistant variants. Nucleotide metabolism is one of the more exploited host metabolic pathways as a potential antiviral target for several human viruses. This review focuses on the antiviral properties of the inhibitors of pyrimidine and purine nucleotide biosynthesis, with an emphasis on the rate-limiting enzymes dihydroorotate dehydrogenase (DHODH) and inosine monophosphate dehydrogenase (IMPDH) for which there are old and new drugs active against a broad spectrum of pathogenic viruses.https://www.mdpi.com/2076-2607/10/8/1631wide-spectrum antiviralhost-targeted antiviralnucleotide metabolism<i>de novo</i> biosynthesis pathwaysalvage pathwaypyrimidines |
| spellingShingle | Claudia Soledad Sepúlveda Cybele Carina García Elsa Beatriz Damonte Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy Microorganisms wide-spectrum antiviral host-targeted antiviral nucleotide metabolism <i>de novo</i> biosynthesis pathway salvage pathway pyrimidines |
| title | Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy |
| title_full | Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy |
| title_fullStr | Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy |
| title_full_unstemmed | Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy |
| title_short | Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy |
| title_sort | inhibitors of nucleotide biosynthesis as candidates for a wide spectrum of antiviral chemotherapy |
| topic | wide-spectrum antiviral host-targeted antiviral nucleotide metabolism <i>de novo</i> biosynthesis pathway salvage pathway pyrimidines |
| url | https://www.mdpi.com/2076-2607/10/8/1631 |
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