Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats
Due to the multifactorial and multisystemic nature of diabetes mellitus, it is often treated with a combination of therapeutic agents having different mode of action. Earlier, we have synthesized several organozinc complexes and evaluated their safety and antidiabetic properties in experimental type...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Diabetes Association
2018-04-01
|
| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-42-244.pdf |
| _version_ | 1828399970699444224 |
|---|---|
| author | Muruganantham Koothappan Roshana Devi Vellai Iyyam Pillai Subramanian Sorimuthu Pillai Subramanian |
| author_facet | Muruganantham Koothappan Roshana Devi Vellai Iyyam Pillai Subramanian Sorimuthu Pillai Subramanian |
| author_sort | Muruganantham Koothappan |
| collection | DOAJ |
| description | Due to the multifactorial and multisystemic nature of diabetes mellitus, it is often treated with a combination of therapeutic agents having different mode of action. Earlier, we have synthesized several organozinc complexes and evaluated their safety and antidiabetic properties in experimental type 2 diabetes mellitus (T2DM). More recently, we have synthesized a metformin-3-hydroxyflavone complex and studied its antidiabetic efficacy in experimental rats. In the present study, a new zinc-mixed ligand (metformin-3-hydroxyflavone) was synthesized, characterized by spectral studies and its antidiabetic properties was evaluated in HFD fed—low dose streptozotocin induced T2DM in rats. The hypoglycemic efficacy of the complex was evaluated through oral glucose tolerance test, homeostasis model assessment of insulin resistance, quantitative insulin sensitivity check index and by determining the status of important biochemical parameters. Oral administration of the complex at a concentration of 10 mg/kg body weight/rat/day for 30 days significantly improved the glucose homeostasis. The complex possesses significant antidiabetic properties relatively at a less concentration than metformin-3-hydroxyflavone complex in ameliorating hyperglycemia. |
| first_indexed | 2024-12-10T09:24:30Z |
| format | Article |
| id | doaj.art-102af5de73854ff083260ca68c2903c1 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-10T09:24:30Z |
| publishDate | 2018-04-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-102af5de73854ff083260ca68c2903c12022-12-22T01:54:34ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872018-04-0142324424810.4093/dmj.2018.0002Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic RatsMuruganantham Koothappan0Roshana Devi Vellai1Iyyam Pillai Subramanian2Sorimuthu Pillai Subramanian3Department of Biochemistry, University of Madras, Guindy Campus, Chennai, .IndiaDepartment of Biochemistry, University of Madras, Guindy Campus, Chennai, .IndiaPG and Research Department of Chemistry, Pachaiyappa's College, Chennai, .IndiaDepartment of Biochemistry, University of Madras, Guindy Campus, Chennai, .IndiaDue to the multifactorial and multisystemic nature of diabetes mellitus, it is often treated with a combination of therapeutic agents having different mode of action. Earlier, we have synthesized several organozinc complexes and evaluated their safety and antidiabetic properties in experimental type 2 diabetes mellitus (T2DM). More recently, we have synthesized a metformin-3-hydroxyflavone complex and studied its antidiabetic efficacy in experimental rats. In the present study, a new zinc-mixed ligand (metformin-3-hydroxyflavone) was synthesized, characterized by spectral studies and its antidiabetic properties was evaluated in HFD fed—low dose streptozotocin induced T2DM in rats. The hypoglycemic efficacy of the complex was evaluated through oral glucose tolerance test, homeostasis model assessment of insulin resistance, quantitative insulin sensitivity check index and by determining the status of important biochemical parameters. Oral administration of the complex at a concentration of 10 mg/kg body weight/rat/day for 30 days significantly improved the glucose homeostasis. The complex possesses significant antidiabetic properties relatively at a less concentration than metformin-3-hydroxyflavone complex in ameliorating hyperglycemia.https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-42-244.pdfDiabetes mellitus, type 2Hypoglycemic agentsMetforminRatsZinc |
| spellingShingle | Muruganantham Koothappan Roshana Devi Vellai Iyyam Pillai Subramanian Sorimuthu Pillai Subramanian Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats Diabetes & Metabolism Journal Diabetes mellitus, type 2 Hypoglycemic agents Metformin Rats Zinc |
| title | Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats |
| title_full | Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats |
| title_fullStr | Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats |
| title_full_unstemmed | Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats |
| title_short | Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats |
| title_sort | synthesis of a new zinc mixed ligand complex and evaluation of its antidiabetic properties in high fat diet low dose streptozotocin induced diabetic rats |
| topic | Diabetes mellitus, type 2 Hypoglycemic agents Metformin Rats Zinc |
| url | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-42-244.pdf |
| work_keys_str_mv | AT murugananthamkoothappan synthesisofanewzincmixedligandcomplexandevaluationofitsantidiabeticpropertiesinhighfatdietlowdosestreptozotocininduceddiabeticrats AT roshanadevivellai synthesisofanewzincmixedligandcomplexandevaluationofitsantidiabeticpropertiesinhighfatdietlowdosestreptozotocininduceddiabeticrats AT iyyampillaisubramanian synthesisofanewzincmixedligandcomplexandevaluationofitsantidiabeticpropertiesinhighfatdietlowdosestreptozotocininduceddiabeticrats AT sorimuthupillaisubramanian synthesisofanewzincmixedligandcomplexandevaluationofitsantidiabeticpropertiesinhighfatdietlowdosestreptozotocininduceddiabeticrats |