Role of Intermediate Filaments in Vesicular Traffic
Intermediate filaments are an important component of the cellular cytoskeleton. The first established role attributed to intermediate filaments was the mechanical support to cells. However, it is now clear that intermediate filaments have many different roles affecting a variety of other biological...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-04-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/5/2/20 |
| _version_ | 1797766148279762944 |
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| author | Azzurra Margiotta Cecilia Bucci |
| author_facet | Azzurra Margiotta Cecilia Bucci |
| author_sort | Azzurra Margiotta |
| collection | DOAJ |
| description | Intermediate filaments are an important component of the cellular cytoskeleton. The first established role attributed to intermediate filaments was the mechanical support to cells. However, it is now clear that intermediate filaments have many different roles affecting a variety of other biological functions, such as the organization of microtubules and microfilaments, the regulation of nuclear structure and activity, the control of cell cycle and the regulation of signal transduction pathways. Furthermore, a number of intermediate filament proteins have been involved in the acquisition of tumorigenic properties. Over the last years, a strong involvement of intermediate filament proteins in the regulation of several aspects of intracellular trafficking has strongly emerged. Here, we review the functions of intermediate filaments proteins focusing mainly on the recent knowledge gained from the discovery that intermediate filaments associate with key proteins of the vesicular membrane transport machinery. In particular, we analyze the current understanding of the contribution of intermediate filaments to the endocytic pathway. |
| first_indexed | 2024-03-12T20:21:03Z |
| format | Article |
| id | doaj.art-102bc9cdc902490aa92dd289d8c5c1f5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T20:21:03Z |
| publishDate | 2016-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-102bc9cdc902490aa92dd289d8c5c1f52023-08-02T00:54:51ZengMDPI AGCells2073-44092016-04-01522010.3390/cells5020020cells5020020Role of Intermediate Filaments in Vesicular TrafficAzzurra Margiotta0Cecilia Bucci1Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Lecce-Monteroni 165, 73100 Lecce, ItalyDepartment of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Provinciale Lecce-Monteroni 165, 73100 Lecce, ItalyIntermediate filaments are an important component of the cellular cytoskeleton. The first established role attributed to intermediate filaments was the mechanical support to cells. However, it is now clear that intermediate filaments have many different roles affecting a variety of other biological functions, such as the organization of microtubules and microfilaments, the regulation of nuclear structure and activity, the control of cell cycle and the regulation of signal transduction pathways. Furthermore, a number of intermediate filament proteins have been involved in the acquisition of tumorigenic properties. Over the last years, a strong involvement of intermediate filament proteins in the regulation of several aspects of intracellular trafficking has strongly emerged. Here, we review the functions of intermediate filaments proteins focusing mainly on the recent knowledge gained from the discovery that intermediate filaments associate with key proteins of the vesicular membrane transport machinery. In particular, we analyze the current understanding of the contribution of intermediate filaments to the endocytic pathway.http://www.mdpi.com/2073-4409/5/2/20intermediate filamentsintracellular traffickingendocytosisexocytosisvimentinmembrane trafficmitosis |
| spellingShingle | Azzurra Margiotta Cecilia Bucci Role of Intermediate Filaments in Vesicular Traffic Cells intermediate filaments intracellular trafficking endocytosis exocytosis vimentin membrane traffic mitosis |
| title | Role of Intermediate Filaments in Vesicular Traffic |
| title_full | Role of Intermediate Filaments in Vesicular Traffic |
| title_fullStr | Role of Intermediate Filaments in Vesicular Traffic |
| title_full_unstemmed | Role of Intermediate Filaments in Vesicular Traffic |
| title_short | Role of Intermediate Filaments in Vesicular Traffic |
| title_sort | role of intermediate filaments in vesicular traffic |
| topic | intermediate filaments intracellular trafficking endocytosis exocytosis vimentin membrane traffic mitosis |
| url | http://www.mdpi.com/2073-4409/5/2/20 |
| work_keys_str_mv | AT azzurramargiotta roleofintermediatefilamentsinvesiculartraffic AT ceciliabucci roleofintermediatefilamentsinvesiculartraffic |