Impact of patent foramen ovale on short-term outcomes in children with biliary atresia undergoing living donor liver transplantation: a retrospective cohort study
Abstract Objective To investigate the impact of patent foramen ovale (PFO) on the short-term outcomes of living donor liver transplantation (LDLT) in children with biliary atresia. Methods With the approval of the hospital ethics committee, 304 children with biliary atresia who underwent LDLT in our...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-023-02268-w |
| _version_ | 1797556899036528640 |
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| author | Yuli Wu Yongle Jing Tianying Li Lu Che Mingwei Sheng Lili Jia Hongxia Li Wenli Yu Yiqi Weng |
| author_facet | Yuli Wu Yongle Jing Tianying Li Lu Che Mingwei Sheng Lili Jia Hongxia Li Wenli Yu Yiqi Weng |
| author_sort | Yuli Wu |
| collection | DOAJ |
| description | Abstract Objective To investigate the impact of patent foramen ovale (PFO) on the short-term outcomes of living donor liver transplantation (LDLT) in children with biliary atresia. Methods With the approval of the hospital ethics committee, 304 children with biliary atresia who underwent LDLT in our center from January 2020 to December 2021 were enrolled. According to the results of echocardiography before the operation, the subjects were divided into the PFO group (n = 73) and the NoPFO group (n = 231). The baseline characteristics; intraoperative recipient-related data and donor-related data; incidence of postreperfusion syndrome (PRS); postoperative mechanical ventilation time; ICU stay duration; postoperative hospital stay duration; liver function index; incidences of postoperative complications including acute renal injury (AKI), graft dysfunction, hepatic artery thrombosis (HAT) and portal vein thrombosis (PVT); and one-year survival rate were compared between the two groups. Results The median age in the PFO group was 6 months and that in the NoPFO group was 9 months (P < 0.001), and the median height (65 cm) and weight (6.5 kg) in the PFO group were significantly lower than those in the NoPFO group (68 cm, 8.0 kg) (P < 0.001). The preoperative total bilirubin level (247 vs. 202 umol/L, P = 0.007) and pediatric end-stage liver disease (PELD) score (21 vs. 16, P = 0.001) in the PFO group were higher than those in the NoPFO group. There were no significant differences in the intraoperative PRS incidence (46.6% vs. 42.4%, P = 0.533 ), postoperative mechanical ventilation time (184 vs. 220 min, P = 0.533), ICU stay duration (3.0 vs. 2.5 d, P = 0.267), postoperative hospital stay duration (22 vs. 21 d, P = 0.138), AKI incidence (19.2% vs. 24.7%, P = 0.333), graft dysfunction incidence (11.0% vs. 12.6%, P = 0.716), HAT incidence (5.5% vs. 4.8%, P = 0.762), PVT incidence (2.7% vs. 2.2%, P = 0.675) or one-year survival rate (94.5% vs. 95.7%, P = 0.929) between the two groups. Conclusion The presence of PFO has no negative impact on short-term outcomes in children with biliary atresia after LDLT. |
| first_indexed | 2024-03-10T17:09:36Z |
| format | Article |
| id | doaj.art-102dc291f1324a15b785f5cd6f24d7ab |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-03-10T17:09:36Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-102dc291f1324a15b785f5cd6f24d7ab2023-11-20T10:42:18ZengBMCBMC Anesthesiology1471-22532023-09-012311710.1186/s12871-023-02268-wImpact of patent foramen ovale on short-term outcomes in children with biliary atresia undergoing living donor liver transplantation: a retrospective cohort studyYuli Wu0Yongle Jing1Tianying Li2Lu Che3Mingwei Sheng4Lili Jia5Hongxia Li6Wenli Yu7Yiqi Weng8Department of Anesthesiology, Tianjin First Central HospitalDepartment of Cardiology, Tianjin First Central HospitalSchool of Medicine, Nankai UniversityDepartment of Anesthesiology, Tianjin First Central HospitalDepartment of Anesthesiology, Tianjin First Central HospitalDepartment of Anesthesiology, Tianjin First Central HospitalDepartment of Anesthesiology, Tianjin First Central HospitalDepartment of Anesthesiology, Tianjin First Central HospitalDepartment of Anesthesiology, Tianjin First Central HospitalAbstract Objective To investigate the impact of patent foramen ovale (PFO) on the short-term outcomes of living donor liver transplantation (LDLT) in children with biliary atresia. Methods With the approval of the hospital ethics committee, 304 children with biliary atresia who underwent LDLT in our center from January 2020 to December 2021 were enrolled. According to the results of echocardiography before the operation, the subjects were divided into the PFO group (n = 73) and the NoPFO group (n = 231). The baseline characteristics; intraoperative recipient-related data and donor-related data; incidence of postreperfusion syndrome (PRS); postoperative mechanical ventilation time; ICU stay duration; postoperative hospital stay duration; liver function index; incidences of postoperative complications including acute renal injury (AKI), graft dysfunction, hepatic artery thrombosis (HAT) and portal vein thrombosis (PVT); and one-year survival rate were compared between the two groups. Results The median age in the PFO group was 6 months and that in the NoPFO group was 9 months (P < 0.001), and the median height (65 cm) and weight (6.5 kg) in the PFO group were significantly lower than those in the NoPFO group (68 cm, 8.0 kg) (P < 0.001). The preoperative total bilirubin level (247 vs. 202 umol/L, P = 0.007) and pediatric end-stage liver disease (PELD) score (21 vs. 16, P = 0.001) in the PFO group were higher than those in the NoPFO group. There were no significant differences in the intraoperative PRS incidence (46.6% vs. 42.4%, P = 0.533 ), postoperative mechanical ventilation time (184 vs. 220 min, P = 0.533), ICU stay duration (3.0 vs. 2.5 d, P = 0.267), postoperative hospital stay duration (22 vs. 21 d, P = 0.138), AKI incidence (19.2% vs. 24.7%, P = 0.333), graft dysfunction incidence (11.0% vs. 12.6%, P = 0.716), HAT incidence (5.5% vs. 4.8%, P = 0.762), PVT incidence (2.7% vs. 2.2%, P = 0.675) or one-year survival rate (94.5% vs. 95.7%, P = 0.929) between the two groups. Conclusion The presence of PFO has no negative impact on short-term outcomes in children with biliary atresia after LDLT.https://doi.org/10.1186/s12871-023-02268-wPatent foramen ovaleLiving donor liver transplantationBiliary atresiaComplication |
| spellingShingle | Yuli Wu Yongle Jing Tianying Li Lu Che Mingwei Sheng Lili Jia Hongxia Li Wenli Yu Yiqi Weng Impact of patent foramen ovale on short-term outcomes in children with biliary atresia undergoing living donor liver transplantation: a retrospective cohort study BMC Anesthesiology Patent foramen ovale Living donor liver transplantation Biliary atresia Complication |
| title | Impact of patent foramen ovale on short-term outcomes in children with biliary atresia undergoing living donor liver transplantation: a retrospective cohort study |
| title_full | Impact of patent foramen ovale on short-term outcomes in children with biliary atresia undergoing living donor liver transplantation: a retrospective cohort study |
| title_fullStr | Impact of patent foramen ovale on short-term outcomes in children with biliary atresia undergoing living donor liver transplantation: a retrospective cohort study |
| title_full_unstemmed | Impact of patent foramen ovale on short-term outcomes in children with biliary atresia undergoing living donor liver transplantation: a retrospective cohort study |
| title_short | Impact of patent foramen ovale on short-term outcomes in children with biliary atresia undergoing living donor liver transplantation: a retrospective cohort study |
| title_sort | impact of patent foramen ovale on short term outcomes in children with biliary atresia undergoing living donor liver transplantation a retrospective cohort study |
| topic | Patent foramen ovale Living donor liver transplantation Biliary atresia Complication |
| url | https://doi.org/10.1186/s12871-023-02268-w |
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