Perspective: The Potential Effects of Naringenin in COVID-19
Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization in March 2020. Severe COVID-19 cases develop severe acute respiratory syndrome, which can result in multiple organ failure, sepsis, an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.570919/full |
| _version_ | 1818295126057811968 |
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| author | Ricardo Wesley Alberca Franciane Mouradian Emidio Teixeira Danielle Rosa Beserra Emily Araujo de Oliveira Milena Mary de Souza Andrade Anna Julia Pietrobon Maria Notomi Sato |
| author_facet | Ricardo Wesley Alberca Franciane Mouradian Emidio Teixeira Danielle Rosa Beserra Emily Araujo de Oliveira Milena Mary de Souza Andrade Anna Julia Pietrobon Maria Notomi Sato |
| author_sort | Ricardo Wesley Alberca |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization in March 2020. Severe COVID-19 cases develop severe acute respiratory syndrome, which can result in multiple organ failure, sepsis, and death. The higher risk group includes the elderly and subjects with pre-existing chronic illnesses such as obesity, hypertension, and diabetes. To date, no specific treatment or vaccine is available for COVID-19. Among many compounds, naringenin (NAR) a flavonoid present in citrus fruits has been investigated for antiviral and anti-inflammatory properties like reducing viral replication and cytokine production. In this perspective, we summarize NAR potential anti-inflammatory role in COVID-19 associated risk factors and SARS-CoV-2 infection. |
| first_indexed | 2024-12-13T03:42:41Z |
| format | Article |
| id | doaj.art-102f7d934d184292b6ce1dafa74372e6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T03:42:41Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-102f7d934d184292b6ce1dafa74372e62022-12-22T00:00:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.570919570919Perspective: The Potential Effects of Naringenin in COVID-19Ricardo Wesley Alberca0Franciane Mouradian Emidio Teixeira1Danielle Rosa Beserra2Emily Araujo de Oliveira3Milena Mary de Souza Andrade4Anna Julia Pietrobon5Maria Notomi Sato6Laboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine and Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, BrazilInstitute of Biomedical Sciences, University of São Paulo, São Paulo, BrazilLaboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine and Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, BrazilLaboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine and Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, BrazilLaboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine and Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, BrazilInstitute of Biomedical Sciences, University of São Paulo, São Paulo, BrazilLaboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine and Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, BrazilCoronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization in March 2020. Severe COVID-19 cases develop severe acute respiratory syndrome, which can result in multiple organ failure, sepsis, and death. The higher risk group includes the elderly and subjects with pre-existing chronic illnesses such as obesity, hypertension, and diabetes. To date, no specific treatment or vaccine is available for COVID-19. Among many compounds, naringenin (NAR) a flavonoid present in citrus fruits has been investigated for antiviral and anti-inflammatory properties like reducing viral replication and cytokine production. In this perspective, we summarize NAR potential anti-inflammatory role in COVID-19 associated risk factors and SARS-CoV-2 infection.https://www.frontiersin.org/article/10.3389/fimmu.2020.570919/fullantiviralanti-inflammatorynaringeninSARS-CoV-2COVID-19TNF |
| spellingShingle | Ricardo Wesley Alberca Franciane Mouradian Emidio Teixeira Danielle Rosa Beserra Emily Araujo de Oliveira Milena Mary de Souza Andrade Anna Julia Pietrobon Maria Notomi Sato Perspective: The Potential Effects of Naringenin in COVID-19 Frontiers in Immunology antiviral anti-inflammatory naringenin SARS-CoV-2 COVID-19 TNF |
| title | Perspective: The Potential Effects of Naringenin in COVID-19 |
| title_full | Perspective: The Potential Effects of Naringenin in COVID-19 |
| title_fullStr | Perspective: The Potential Effects of Naringenin in COVID-19 |
| title_full_unstemmed | Perspective: The Potential Effects of Naringenin in COVID-19 |
| title_short | Perspective: The Potential Effects of Naringenin in COVID-19 |
| title_sort | perspective the potential effects of naringenin in covid 19 |
| topic | antiviral anti-inflammatory naringenin SARS-CoV-2 COVID-19 TNF |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.570919/full |
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