Overview of Physicochemical Properties of Nanoparticles as Drug Carriers for Targeted Cancer Therapy
The advent of nanotechnology has brought about revolutionary innovations in biological research techniques and medical practice. In recent years, various “smart” nanocarriers have been introduced to deliver therapeutic agents specifically to the tumor tissue in a controlled manner, thereby minimizin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/4/196 |
| _version_ | 1797456976629727232 |
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| author | Vugar Yagublu Aynura Karimova Javahir Hajibabazadeh Christoph Reissfelder Mustafa Muradov Stefano Bellucci Adil Allahverdiyev |
| author_facet | Vugar Yagublu Aynura Karimova Javahir Hajibabazadeh Christoph Reissfelder Mustafa Muradov Stefano Bellucci Adil Allahverdiyev |
| author_sort | Vugar Yagublu |
| collection | DOAJ |
| description | The advent of nanotechnology has brought about revolutionary innovations in biological research techniques and medical practice. In recent years, various “smart” nanocarriers have been introduced to deliver therapeutic agents specifically to the tumor tissue in a controlled manner, thereby minimizing their side effects and reducing both dosage and dosage frequency. A large number of nanoparticles have demonstrated initial success in preclinical evaluation but modest therapeutic benefits in the clinical setting, partly due to insufficient delivery to the tumor site and penetration in tumor tissue. Therefore, a precise understanding of the relationships betweenthe physicochemical properties of nanoparticles and their interaction with the surrounding microenvironment in the body is extremely important for achieving higher concentrations and better functionality in tumor tissues. This knowledge would help to effectively combine multiple advantageous functions in one nanoparticle. The main focus of the discussion in this review, therefore, will relate to the main physicochemical properties of nanoparticles while interacting within the body and their tuning potential for increased performance. |
| first_indexed | 2024-03-09T16:15:30Z |
| format | Article |
| id | doaj.art-10337c5f0c72430da660b694e9e2a034 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T16:15:30Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-10337c5f0c72430da660b694e9e2a0342023-11-24T15:49:17ZengMDPI AGJournal of Functional Biomaterials2079-49832022-10-0113419610.3390/jfb13040196Overview of Physicochemical Properties of Nanoparticles as Drug Carriers for Targeted Cancer TherapyVugar Yagublu0Aynura Karimova1Javahir Hajibabazadeh2Christoph Reissfelder3Mustafa Muradov4Stefano Bellucci5Adil Allahverdiyev6Department of Surgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, GermanyNanoresearch Laboratory, Baku State University, AZ 1148 Baku, AzerbaijanNanoresearch Laboratory, Baku State University, AZ 1148 Baku, AzerbaijanDepartment of Surgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, GermanyNanoresearch Laboratory, Baku State University, AZ 1148 Baku, AzerbaijanIstituto Nazionale di Fisica Nucleare—Laboratori Nazionali di Frascati, Via E. Fermi 54, 00044 Frascati, ItalyVali Akhundov National Scientific Research Medical Prophylactic Institute, AZ 1065 Baku, AzerbaijanThe advent of nanotechnology has brought about revolutionary innovations in biological research techniques and medical practice. In recent years, various “smart” nanocarriers have been introduced to deliver therapeutic agents specifically to the tumor tissue in a controlled manner, thereby minimizing their side effects and reducing both dosage and dosage frequency. A large number of nanoparticles have demonstrated initial success in preclinical evaluation but modest therapeutic benefits in the clinical setting, partly due to insufficient delivery to the tumor site and penetration in tumor tissue. Therefore, a precise understanding of the relationships betweenthe physicochemical properties of nanoparticles and their interaction with the surrounding microenvironment in the body is extremely important for achieving higher concentrations and better functionality in tumor tissues. This knowledge would help to effectively combine multiple advantageous functions in one nanoparticle. The main focus of the discussion in this review, therefore, will relate to the main physicochemical properties of nanoparticles while interacting within the body and their tuning potential for increased performance.https://www.mdpi.com/2079-4983/13/4/196nanoparticlestumor microenvironmentdrug carriersprotein coronasurface modification |
| spellingShingle | Vugar Yagublu Aynura Karimova Javahir Hajibabazadeh Christoph Reissfelder Mustafa Muradov Stefano Bellucci Adil Allahverdiyev Overview of Physicochemical Properties of Nanoparticles as Drug Carriers for Targeted Cancer Therapy Journal of Functional Biomaterials nanoparticles tumor microenvironment drug carriers protein corona surface modification |
| title | Overview of Physicochemical Properties of Nanoparticles as Drug Carriers for Targeted Cancer Therapy |
| title_full | Overview of Physicochemical Properties of Nanoparticles as Drug Carriers for Targeted Cancer Therapy |
| title_fullStr | Overview of Physicochemical Properties of Nanoparticles as Drug Carriers for Targeted Cancer Therapy |
| title_full_unstemmed | Overview of Physicochemical Properties of Nanoparticles as Drug Carriers for Targeted Cancer Therapy |
| title_short | Overview of Physicochemical Properties of Nanoparticles as Drug Carriers for Targeted Cancer Therapy |
| title_sort | overview of physicochemical properties of nanoparticles as drug carriers for targeted cancer therapy |
| topic | nanoparticles tumor microenvironment drug carriers protein corona surface modification |
| url | https://www.mdpi.com/2079-4983/13/4/196 |
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