The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation

The complex formation of MASP-3 with pattern recognition molecules of the lectin complement pathway retains MASP-3 in the circulation

The complement system plays an important role in host defense and is activated via three different activation pathways. We have previously reported that mannose-binding lectin-associated serine protease (MASP)-3, unlike its splicing variant MASP-1, circulates in an active form and is essential for t...

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Bibliographic Details
Main Authors: Kohei Kusakari, Takeshi Machida, Yumi Ishida, Tomoko Omori, Toshiyuki Suzuki, Masayuki Sekimata, Ikuo Wada, Teizo Fujita, Hideharu Sekine
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
complement
MASP-3
alternative pathway
lectin pathway
pattern recognition molecules
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.907023/full

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