Proton currents constrain structural models of voltage sensor activation

Proton currents constrain structural models of voltage sensor activation

The Hv1 proton channel is evidently unique among voltage sensor domain proteins in mediating an intrinsic ‘aqueous’ H+ conductance (GAQ). Mutation of a highly conserved ‘gating charge’ residue in the S4 helix (R1H) confers a resting-state H+ ‘shuttle’ conductance (GSH) in VGCs and Ci VSP, and we now...

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Detalles Bibliográficos
Autores principales:	Aaron L Randolph, Younes Mokrab, Ashley L Bennett, Mark SP Sansom, Ian Scott Ramsey
Formato:	Artículo
Lenguaje:	English
Publicado:	eLife Sciences Publications Ltd 2016-08-01
Colección:	eLife
Materias:	proton transport membrane channels channel gating voltage sensor protein structure
Acceso en línea:	https://elifesciences.org/articles/18017

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