Proton currents constrain structural models of voltage sensor activation

Proton currents constrain structural models of voltage sensor activation

The Hv1 proton channel is evidently unique among voltage sensor domain proteins in mediating an intrinsic ‘aqueous’ H+ conductance (GAQ). Mutation of a highly conserved ‘gating charge’ residue in the S4 helix (R1H) confers a resting-state H+ ‘shuttle’ conductance (GSH) in VGCs and Ci VSP, and we now...

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Bibliografiske detaljer
Main Authors:	Aaron L Randolph, Younes Mokrab, Ashley L Bennett, Mark SP Sansom, Ian Scott Ramsey
Format:	Article
Sprog:	English
Udgivet:	eLife Sciences Publications Ltd 2016-08-01
Serier:	eLife
Fag:	proton transport membrane channels channel gating voltage sensor protein structure
Online adgang:	https://elifesciences.org/articles/18017

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