Proton currents constrain structural models of voltage sensor activation

Proton currents constrain structural models of voltage sensor activation

The Hv1 proton channel is evidently unique among voltage sensor domain proteins in mediating an intrinsic ‘aqueous’ H+ conductance (GAQ). Mutation of a highly conserved ‘gating charge’ residue in the S4 helix (R1H) confers a resting-state H+ ‘shuttle’ conductance (GSH) in VGCs and Ci VSP, and we now...

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Bibliographic Details
Main Authors: Aaron L Randolph, Younes Mokrab, Ashley L Bennett, Mark SP Sansom, Ian Scott Ramsey
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-08-01
Series:eLife
Subjects:
proton transport
membrane channels
channel gating
voltage sensor
protein structure
Online Access:https://elifesciences.org/articles/18017

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