Proton currents constrain structural models of voltage sensor activation

Proton currents constrain structural models of voltage sensor activation

The Hv1 proton channel is evidently unique among voltage sensor domain proteins in mediating an intrinsic ‘aqueous’ H+ conductance (GAQ). Mutation of a highly conserved ‘gating charge’ residue in the S4 helix (R1H) confers a resting-state H+ ‘shuttle’ conductance (GSH) in VGCs and Ci VSP, and we now...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Aaron L Randolph, Younes Mokrab, Ashley L Bennett, Mark SP Sansom, Ian Scott Ramsey
Формат:	Өгүүллэг
Хэл сонгох:	English
Хэвлэсэн:	eLife Sciences Publications Ltd 2016-08-01
Цуврал:	eLife
Нөхцлүүд:	proton transport membrane channels channel gating voltage sensor protein structure
Онлайн хандалт:	https://elifesciences.org/articles/18017

Ижил төстэй зүйлс

Structural dynamics determine voltage and pH gating in human voltage-gated proton channel
-н: Shuo Han, зэрэг
Хэвлэсэн: (2022-03-01)

Water, Protons, and the Gating of Voltage-Gated Potassium Channels
-н: Alisher M. Kariev, зэрэг
Хэвлэсэн: (2024-01-01)

Alpha-1 Antitrypsin Augmentation Inhibits Proteolysis of Neutrophil Membrane Voltage-Gated Proton Channel-1 in Alpha-1 Deficient Individuals
-н: Padraig Hawkins, зэрэг
Хэвлэсэн: (2021-08-01)

Neurovascular protection in voltage‐gated proton channel Hv1 knock‐out rats after ischemic stroke: interaction with Na+/H+ exchanger‐1 antagonism
-н: Weiguo Li, зэрэг
Хэвлэсэн: (2019-07-01)

Phosphatidic acid modulation of Kv channel voltage sensor function
-н: Richard K Hite, зэрэг
Хэвлэсэн: (2014-10-01)

The Role of Proton Transport in Gating Current in a Voltage Gated Ion Channel, as Shown by Quantum Calculations
-н: Alisher M. Kariev, зэрэг
Хэвлэсэн: (2018-09-01)

The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury
-н: Madhuvika Murugan, зэрэг
Хэвлэсэн: (2020-10-01)

Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente Local anesthetics: interaction with biological membranes and with the voltage-gated sodium channel
-н: Daniele Ribeiro de Araujo, зэрэг
Хэвлэсэн: (2008-01-01)

Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K+ and Na+ Channels
-н: Kenny M. Van Theemsche, зэрэг
Хэвлэсэн: (2020-05-01)

Protons in Gating the Kv1.2 Channel: A Calculated Set of Protonation States in Response to Polarization/Depolarization of the Channel, with the Complete Proposed Proton Path from Voltage Sensing Domain to Gate
-н: Alisher M. Kariev, зэрэг
Хэвлэсэн: (2022-07-01)

Activation-pathway transitions in human voltage-gated proton channels revealed by a non-canonical fluorescent amino acid
-н: Esteban Suárez-Delgado, зэрэг
Хэвлэсэн: (2023-01-01)

Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function
-н: Richard J. Lewis, зэрэг
Хэвлэсэн: (2006-04-01)

Proton Quantum Tunneling: Influence and Relevance to Acidosis-Induced Cardiac Arrhythmias/Cardiac Arrest
-н: Omar Ababneh, зэрэг
Хэвлэсэн: (2021-09-01)

Dual Regulation of Voltage-Sensitive Ion Channels by PIP2
-н: Aldo A Rodríguez Menchaca, зэрэг
Хэвлэсэн: (2012-09-01)

Molecular mechanisms underlying pimaric acid-induced modulation of voltage-gated K+ channels
-н: Kazuho Sakamoto, зэрэг
Хэвлэсэн: (2017-04-01)

Gating Mechanism of the Voltage-Gated Proton Channel Studied by Molecular Dynamics Simulations
-н: Thi Tuong Vy Phan, зэрэг
Хэвлэсэн: (2022-03-01)

Structural and functional characterization of an otopetrin family proton channel
-н: Qingfeng Chen, зэрэг
Хэвлэсэн: (2019-04-01)

Expert Consensus on Ion Channel Drugs for Chronic Pain Treatment in China
-н: Ma K, зэрэг
Хэвлэсэн: (2024-03-01)

5-Chloro-2-Guanidinobenzimidazole (ClGBI) Is a Non-Selective Inhibitor of the Human H<sub>V</sub>1 Channel
-н: Tibor G. Szanto, зэрэг
Хэвлэсэн: (2023-04-01)

Optical measurement of gating pore currents in hypokalemic periodic paralysis model cells
-н: Tomoya Kubota, зэрэг
Хэвлэсэн: (2023-06-01)

Proton transfer pathway in anion channelrhodopsin-1
-н: Masaki Tsujimura, зэрэг
Хэвлэсэн: (2021-12-01)

Comparison of Fitting Current–Voltage Characteristics Curves of FinFET Transistors with Various Fixed Parameters
-н: Hsin-Chia Yang, зэрэг
Хэвлэсэн: (2022-10-01)

An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel
-н: Fan Yang, зэрэг
Хэвлэсэн: (2020-10-01)

TPEN attenuates amyloid-β25–35-induced neuronal damage with changes in the electrophysiological properties of voltage-gated sodium and potassium channels
-н: Wen-bo Chen, зэрэг
Хэвлэсэн: (2021-08-01)

Discovery and characterization of Hv1-type proton channels in reef-building corals
-н: Gisela Rangel-Yescas, зэрэг
Хэвлэсэн: (2021-08-01)

Marine Toxins That Target Voltage-gated Sodium Channels
-н: Robert J. French, зэрэг
Хэвлэсэн: (2006-04-01)

Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies
-н: Eleonora eSavio Galimberti, зэрэг
Хэвлэсэн: (2012-07-01)

Abstract P-10: Comparison of Ion Coordination in Similar Selectivity Filters of Bacterial Sodium and Eukaryotic Calcium Voltage-Gated Channels
-н: Ivan N. Terterov, зэрэг
Хэвлэсэн: (2019-06-01)

Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels
-н: James R. Groome
Хэвлэсэн: (2023-03-01)

Inhibitory effects of linalool, an essential oil component of lavender, on nociceptive TRPA1 and voltage-gated Ca2+ channels in mouse sensory neurons
-н: Miho Hashimoto, зэрэг
Хэвлэсэн: (2023-07-01)

Hysteretic Behavior in Voltage-Gated Channels
-н: Carlos A. Villalba-Galea, зэрэг
Хэвлэсэн: (2020-11-01)

Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state
-н: Keenan C Taylor, зэрэг
Хэвлэсэн: (2020-02-01)

Coupling of voltage sensors to the channel pore: a comparative view
-н: Vitya eVardanyan, зэрэг
Хэвлэсэн: (2012-07-01)

An examination of plasma autoantibodies against voltage gated calcium channels in schizophrenia
-н: Ryan Thomas McLean, зэрэг
Хэвлэсэн: (2023-03-01)

Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels
-н: Steve Peigneur, зэрэг
Хэвлэсэн: (2014-04-01)

Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
-н: Xiaowei Hou, зэрэг
Хэвлэсэн: (2020-11-01)

1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain
-н: Yuan Zhou, зэрэг
Хэвлэсэн: (2020-05-01)

Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus
-н: Bochuan Teng, зэрэг
Хэвлэсэн: (2023-04-01)

The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel
-н: Juan Zhao, зэрэг
Хэвлэсэн: (2016-10-01)

Protofibrillar Amyloid Beta Modulation of Recombinant hCaV2.2 (N-Type) Voltage-Gated Channels
-н: Eleni Kaisis, зэрэг
Хэвлэсэн: (2022-11-01)