Proton currents constrain structural models of voltage sensor activation

Proton currents constrain structural models of voltage sensor activation

The Hv1 proton channel is evidently unique among voltage sensor domain proteins in mediating an intrinsic ‘aqueous’ H+ conductance (GAQ). Mutation of a highly conserved ‘gating charge’ residue in the S4 helix (R1H) confers a resting-state H+ ‘shuttle’ conductance (GSH) in VGCs and Ci VSP, and we now...

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Chi tiết về thư mục
Những tác giả chính:	Aaron L Randolph, Younes Mokrab, Ashley L Bennett, Mark SP Sansom, Ian Scott Ramsey
Định dạng:	Bài viết
Ngôn ngữ:	English
Được phát hành:	eLife Sciences Publications Ltd 2016-08-01
Loạt:	eLife
Những chủ đề:	proton transport membrane channels channel gating voltage sensor protein structure
Truy cập trực tuyến:	https://elifesciences.org/articles/18017

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