Control of T Cell Responses, Tolerance and Autoimmunity by Regulatory T Cells: Current Concepts
Regulatory T cells have emerged as an important mechanism of regulating tolerance and T cell responses. CD4+ regulatory T cells can be divided into two main groups, natural regulatory T cells, which express high levels of CD25 on their cell surface and phenotypically diverse adaptive (antigen induce...
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| Format: | Article |
| Language: | English |
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Karolinum Press
2003-01-01
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| Series: | Acta Medica |
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| Online Access: | https://actamedica.lfhk.cuni.cz/46/4/0131/ |
| _version_ | 1818016122503430144 |
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| author | Pavel Chrobák |
| author_facet | Pavel Chrobák |
| author_sort | Pavel Chrobák |
| collection | DOAJ |
| description | Regulatory T cells have emerged as an important mechanism of regulating tolerance and T cell responses. CD4+ regulatory T cells can be divided into two main groups, natural regulatory T cells, which express high levels of CD25 on their cell surface and phenotypically diverse adaptive (antigen induced) regulatory T cells. Natural regulatory T cells are made in the thymus, and require strong costimulatory signals for induction and maintenance, express a transcription factor called Foxp3, and function by a largely unknown mechanism. Adaptive (antigen induced) regulatory T cells are made by sub-optimal antigenic signals in the periphery, in the presence of immunosuppressive cytokines, often in special circumstances, such as chronic viral infections or after mucosal administration of antigen, and rely on cytokines such as IL-10 and TGF-β for suppression. Regulatory T cells offer a great potential for the treatment of autoimmune diseases and during transplantation. |
| first_indexed | 2024-04-14T07:07:44Z |
| format | Article |
| id | doaj.art-1036a37798c8493a93211a2a79d96d7d |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-04-14T07:07:44Z |
| publishDate | 2003-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-1036a37798c8493a93211a2a79d96d7d2022-12-22T02:06:31ZengKarolinum PressActa Medica1211-42861805-96942003-01-0146413113710.14712/18059694.2019.22Control of T Cell Responses, Tolerance and Autoimmunity by Regulatory T Cells: Current ConceptsPavel Chrobák0Institute of Clinical Research of Montreal, Molecular Biology Unit, Montreal, Quebec, CanadaRegulatory T cells have emerged as an important mechanism of regulating tolerance and T cell responses. CD4+ regulatory T cells can be divided into two main groups, natural regulatory T cells, which express high levels of CD25 on their cell surface and phenotypically diverse adaptive (antigen induced) regulatory T cells. Natural regulatory T cells are made in the thymus, and require strong costimulatory signals for induction and maintenance, express a transcription factor called Foxp3, and function by a largely unknown mechanism. Adaptive (antigen induced) regulatory T cells are made by sub-optimal antigenic signals in the periphery, in the presence of immunosuppressive cytokines, often in special circumstances, such as chronic viral infections or after mucosal administration of antigen, and rely on cytokines such as IL-10 and TGF-β for suppression. Regulatory T cells offer a great potential for the treatment of autoimmune diseases and during transplantation.https://actamedica.lfhk.cuni.cz/46/4/0131/Regulatory T cellsToleranceAutoimmunityTransplantationInfection |
| spellingShingle | Pavel Chrobák Control of T Cell Responses, Tolerance and Autoimmunity by Regulatory T Cells: Current Concepts Acta Medica Regulatory T cells Tolerance Autoimmunity Transplantation Infection |
| title | Control of T Cell Responses, Tolerance and Autoimmunity by Regulatory T Cells: Current Concepts |
| title_full | Control of T Cell Responses, Tolerance and Autoimmunity by Regulatory T Cells: Current Concepts |
| title_fullStr | Control of T Cell Responses, Tolerance and Autoimmunity by Regulatory T Cells: Current Concepts |
| title_full_unstemmed | Control of T Cell Responses, Tolerance and Autoimmunity by Regulatory T Cells: Current Concepts |
| title_short | Control of T Cell Responses, Tolerance and Autoimmunity by Regulatory T Cells: Current Concepts |
| title_sort | control of t cell responses tolerance and autoimmunity by regulatory t cells current concepts |
| topic | Regulatory T cells Tolerance Autoimmunity Transplantation Infection |
| url | https://actamedica.lfhk.cuni.cz/46/4/0131/ |
| work_keys_str_mv | AT pavelchrobak controloftcellresponsestoleranceandautoimmunitybyregulatorytcellscurrentconcepts |