DSP-0509, a systemically available TLR7 agonist, exhibits combination effect with immune checkpoint blockade by activating anti-tumor immune effects

DSP-0509, a systemically available TLR7 agonist, exhibits combination effect with immune checkpoint blockade by activating anti-tumor immune effects

TLR7 is an innate immune receptor that recognizes single-stranded RNAs, and its activation leads to anti-tumor immune effects. Although it is the only approved TLR7 agonist in cancer therapy, imiquimod is allowed to be administered with topical formulation. Thus, systemic administrative TLR7 agonist...

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Bibliographic Details
Main Authors: Yosuke Ota, Yasuhiro Nagai, Yuko Hirose, Seiji Hori, Erina Koga-Yamakawa, Ken Eguchi, Kentaro Sumida, Masashi Murata, Hiroki Umehara, Setsuko Yamamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
TLR7 agonist
DSP-0509
check point blocker
combination
effector memory T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1055671/full

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