Obesity and chronic kidney disease: prevalence, mechanism, and management
The prevalence of childhood obesity is increasing worldwide at an alarming rate. While obesity is known to increase a variety of cardiovascular and metabolic diseases, it also acts as a risk factor for the development and progression of chronic kidney disease (CKD). During childhood and adolescence,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2021-10-01
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| Series: | Clinical and Experimental Pediatrics |
| Subjects: | |
| Online Access: | http://www.e-cep.org/upload/pdf/cep-2021-00108.pdf |
| _version_ | 1818986711363878912 |
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| author | Hyung Eun Yim Kee Hwan Yoo |
| author_facet | Hyung Eun Yim Kee Hwan Yoo |
| author_sort | Hyung Eun Yim |
| collection | DOAJ |
| description | The prevalence of childhood obesity is increasing worldwide at an alarming rate. While obesity is known to increase a variety of cardiovascular and metabolic diseases, it also acts as a risk factor for the development and progression of chronic kidney disease (CKD). During childhood and adolescence, severe obesity is associated with an increased prevalence and incidence of the early stages of kidney disease. Importantly, children born to obese mothers are also at increased risk of developing obesity and CKD later in life. The potential mechanisms underlying the association between obesity and CKD include hemodynamic factors, metabolic effects, and lipid nephrotoxicity. Weight reduction via increased physical activity, caloric restriction, treatment with angiotensin-converting enzyme inhibitors, and judicious bariatric surgery can be used to control obesity and obesity-related kidney disease. Preventive strategies to halt the obesity epidemic in the healthcare community are needed to reduce the widespread deleterious consequences of obesity including CKD development and progression. |
| first_indexed | 2024-12-20T18:55:08Z |
| format | Article |
| id | doaj.art-103c57f022834dab8c62f42bdc94f374 |
| institution | Directory Open Access Journal |
| issn | 2713-4148 |
| language | English |
| last_indexed | 2024-12-20T18:55:08Z |
| publishDate | 2021-10-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj.art-103c57f022834dab8c62f42bdc94f3742022-12-21T19:29:31ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482021-10-01641051151810.3345/cep.2021.0010820125555429Obesity and chronic kidney disease: prevalence, mechanism, and managementHyung Eun Yim0Kee Hwan Yoo1 Department of Pediatrics, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine, Seoul, KoreaThe prevalence of childhood obesity is increasing worldwide at an alarming rate. While obesity is known to increase a variety of cardiovascular and metabolic diseases, it also acts as a risk factor for the development and progression of chronic kidney disease (CKD). During childhood and adolescence, severe obesity is associated with an increased prevalence and incidence of the early stages of kidney disease. Importantly, children born to obese mothers are also at increased risk of developing obesity and CKD later in life. The potential mechanisms underlying the association between obesity and CKD include hemodynamic factors, metabolic effects, and lipid nephrotoxicity. Weight reduction via increased physical activity, caloric restriction, treatment with angiotensin-converting enzyme inhibitors, and judicious bariatric surgery can be used to control obesity and obesity-related kidney disease. Preventive strategies to halt the obesity epidemic in the healthcare community are needed to reduce the widespread deleterious consequences of obesity including CKD development and progression.http://www.e-cep.org/upload/pdf/cep-2021-00108.pdffetal developmentintergenerational relationspediatric obesityproteinuriarenal insufficiency |
| spellingShingle | Hyung Eun Yim Kee Hwan Yoo Obesity and chronic kidney disease: prevalence, mechanism, and management Clinical and Experimental Pediatrics fetal development intergenerational relations pediatric obesity proteinuria renal insufficiency |
| title | Obesity and chronic kidney disease: prevalence, mechanism, and management |
| title_full | Obesity and chronic kidney disease: prevalence, mechanism, and management |
| title_fullStr | Obesity and chronic kidney disease: prevalence, mechanism, and management |
| title_full_unstemmed | Obesity and chronic kidney disease: prevalence, mechanism, and management |
| title_short | Obesity and chronic kidney disease: prevalence, mechanism, and management |
| title_sort | obesity and chronic kidney disease prevalence mechanism and management |
| topic | fetal development intergenerational relations pediatric obesity proteinuria renal insufficiency |
| url | http://www.e-cep.org/upload/pdf/cep-2021-00108.pdf |
| work_keys_str_mv | AT hyungeunyim obesityandchronickidneydiseaseprevalencemechanismandmanagement AT keehwanyoo obesityandchronickidneydiseaseprevalencemechanismandmanagement |