High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case report
Serous tubal intraepithelial carcinoma (STIC) is a precancerous lesion of high-grade serous ovarian carcinoma (HGSOC). Usually, it arises from the fimbrial end of the tube, and it is associated with metastatic potential. On average, the time to progress from STIC to HGSOC is 6.5 years. Therefore, wh...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1307573/full |
| _version_ | 1797333058115862528 |
|---|---|
| author | Paola Giancontieri Camilla Turetta Giacomo Barchiesi Angelina Pernazza Gemma Pignataro Giuliano D’Onghia Daniele Santini Federica Tomao |
| author_facet | Paola Giancontieri Camilla Turetta Giacomo Barchiesi Angelina Pernazza Gemma Pignataro Giuliano D’Onghia Daniele Santini Federica Tomao |
| author_sort | Paola Giancontieri |
| collection | DOAJ |
| description | Serous tubal intraepithelial carcinoma (STIC) is a precancerous lesion of high-grade serous ovarian carcinoma (HGSOC). Usually, it arises from the fimbrial end of the tube, and it is associated with metastatic potential. On average, the time to progress from STIC to HGSOC is 6.5 years. Therefore, whenever a STIC lesion is found, surgical staging and prophylactic salpingectomy are recommended in order to prevent ovarian cancer. We report a rare case of a 45-year-old female patient who clinically presented an isolated right inguinal lymphadenopathy. The remaining clinical examination was normal. Therefore, an excisional biopsy of the lymph node was performed. Pathological analysis revealed a high-grade serous carcinoma, most likely of gynecological origin. Due to histological evidence, a computed tomography (CT) scan was carried out. There was no CT evidence of ovarian disease, pelvic involvement, intra-abdominal lymphadenopathies, metastatic disease, or ascites. All tumor markers were negative. The patient underwent laparoscopic hysterectomy and bilateral salpingo-oophorectomy followed by surgical staging. Surprisingly, pathological examination showed a STIC lesion in the fimbria of the left fallopian tube. We aim to report the potential capability of STIC to spread particularly through lymphatic pathways rather than peritoneal dissemination. |
| first_indexed | 2024-03-08T07:58:20Z |
| format | Article |
| id | doaj.art-103c7ca218e6408b93bef18c8d678a76 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T07:58:20Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-103c7ca218e6408b93bef18c8d678a762024-02-02T12:50:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011310.3389/fonc.2023.13075731307573High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case reportPaola Giancontieri0Camilla Turetta1Giacomo Barchiesi2Angelina Pernazza3Gemma Pignataro4Giuliano D’Onghia5Daniele Santini6Federica Tomao7Department of Radiological, Oncological and Anatomo-Pathological Science, Policlinico Umberto I, Sapienza University of Rome, Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Anatomo-Pathological Science, Policlinico Umberto I, Sapienza University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Anatomo-Pathological Science, Policlinico Umberto I, Sapienza University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Anatomo-Pathological Science, Policlinico Umberto I, Sapienza University of Rome, Rome, ItalyDepartment of Surgery, Sapienza University of Rome, Rome, ItalyDepartment of Radiological, Oncological and Anatomo-Pathological Science, Policlinico Umberto I, Sapienza University of Rome, Rome, ItalyDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, ItalySerous tubal intraepithelial carcinoma (STIC) is a precancerous lesion of high-grade serous ovarian carcinoma (HGSOC). Usually, it arises from the fimbrial end of the tube, and it is associated with metastatic potential. On average, the time to progress from STIC to HGSOC is 6.5 years. Therefore, whenever a STIC lesion is found, surgical staging and prophylactic salpingectomy are recommended in order to prevent ovarian cancer. We report a rare case of a 45-year-old female patient who clinically presented an isolated right inguinal lymphadenopathy. The remaining clinical examination was normal. Therefore, an excisional biopsy of the lymph node was performed. Pathological analysis revealed a high-grade serous carcinoma, most likely of gynecological origin. Due to histological evidence, a computed tomography (CT) scan was carried out. There was no CT evidence of ovarian disease, pelvic involvement, intra-abdominal lymphadenopathies, metastatic disease, or ascites. All tumor markers were negative. The patient underwent laparoscopic hysterectomy and bilateral salpingo-oophorectomy followed by surgical staging. Surprisingly, pathological examination showed a STIC lesion in the fimbria of the left fallopian tube. We aim to report the potential capability of STIC to spread particularly through lymphatic pathways rather than peritoneal dissemination.https://www.frontiersin.org/articles/10.3389/fonc.2023.1307573/fullSTICHGSOCovarian, cancerlymphadenopathymetastasisp53 |
| spellingShingle | Paola Giancontieri Camilla Turetta Giacomo Barchiesi Angelina Pernazza Gemma Pignataro Giuliano D’Onghia Daniele Santini Federica Tomao High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case report Frontiers in Oncology STIC HGSOC ovarian, cancer lymphadenopathy metastasis p53 |
| title | High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case report |
| title_full | High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case report |
| title_fullStr | High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case report |
| title_full_unstemmed | High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case report |
| title_short | High-grade serous carcinoma of unknown primary origin associated with STIC clinically presented as isolated inguinal lymphadenopathy: a case report |
| title_sort | high grade serous carcinoma of unknown primary origin associated with stic clinically presented as isolated inguinal lymphadenopathy a case report |
| topic | STIC HGSOC ovarian, cancer lymphadenopathy metastasis p53 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1307573/full |
| work_keys_str_mv | AT paolagiancontieri highgradeserouscarcinomaofunknownprimaryoriginassociatedwithsticclinicallypresentedasisolatedinguinallymphadenopathyacasereport AT camillaturetta highgradeserouscarcinomaofunknownprimaryoriginassociatedwithsticclinicallypresentedasisolatedinguinallymphadenopathyacasereport AT giacomobarchiesi highgradeserouscarcinomaofunknownprimaryoriginassociatedwithsticclinicallypresentedasisolatedinguinallymphadenopathyacasereport AT angelinapernazza highgradeserouscarcinomaofunknownprimaryoriginassociatedwithsticclinicallypresentedasisolatedinguinallymphadenopathyacasereport AT gemmapignataro highgradeserouscarcinomaofunknownprimaryoriginassociatedwithsticclinicallypresentedasisolatedinguinallymphadenopathyacasereport AT giulianodonghia highgradeserouscarcinomaofunknownprimaryoriginassociatedwithsticclinicallypresentedasisolatedinguinallymphadenopathyacasereport AT danielesantini highgradeserouscarcinomaofunknownprimaryoriginassociatedwithsticclinicallypresentedasisolatedinguinallymphadenopathyacasereport AT federicatomao highgradeserouscarcinomaofunknownprimaryoriginassociatedwithsticclinicallypresentedasisolatedinguinallymphadenopathyacasereport |