Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors Avaliação de algumas seqüelas bucais pós-radioterapia em pacientes tratados de neoplasias de cabeça e pescoço
The aim of this study was to evaluate the oral sequelae of radiotherapy in patients treated between 1999 and 2003 for head and neck tumors. One-hundred patients (24 women, 76 men) ranging in age from 30 to 83 years (mean 59.2 years) were examined. Time since radiotherapy ranged from 1 to 72 months (...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Pesquisa Odontológica
2007-09-01
|
| Series: | Brazilian Oral Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242007000300014 |
| _version_ | 1818365613901348864 |
|---|---|
| author | Cássia Maria Fischer Rubira Nádia Juliana Devides Liliane Torsani Úbeda Antônio Geraldo Bortolucci Jr José Roberto Lauris Izabel Regina Fischer Rubira-Bullen José Humberto Damante |
| author_facet | Cássia Maria Fischer Rubira Nádia Juliana Devides Liliane Torsani Úbeda Antônio Geraldo Bortolucci Jr José Roberto Lauris Izabel Regina Fischer Rubira-Bullen José Humberto Damante |
| author_sort | Cássia Maria Fischer Rubira |
| collection | DOAJ |
| description | The aim of this study was to evaluate the oral sequelae of radiotherapy in patients treated between 1999 and 2003 for head and neck tumors. One-hundred patients (24 women, 76 men) ranging in age from 30 to 83 years (mean 59.2 years) were examined. Time since radiotherapy ranged from 1 to 72 months (mean 28 months). The total mean radiation dose received by the patients was 5,955 cGy. The evaluation protocol included anamnesis, intraoral and extraoral examination, measurement of stimulated salivary flow and salivary pH. Symptoms reported by the patients included dry mouth (68%), dysphagia (38%), and dysgeusia (30%). In 64% of the patients, the mean stimulated salivary flow rate was less than 0.7 ml/min. The mean salivary pH was 6.97 (± 0.714). Stimulated salivary flow increased with increasing postradiotherapy time (p < 0.05). The prevalence of mucositis was associated with higher radiation doses (p < 0.05), and the prevalence of atrophic candidiasis was related to a longer post-treatment period (p < 0.05). Two cases of recurrence of the primary tumor were detected during the study. The main effect of radiotheraphy in the head and neck region was a reduction of the salivary flow rate, even though our study demonstrated that there was a modest late improvement of the salivary flow.<br>O objetivo deste estudo foi avaliar as seqüelas bucais provocadas pela radioterapia em pacientes com neoplasias de cabeça e pescoço, tratados entre 1999 e 2003. Foram examinados 100 pacientes (24 mulheres e 76 homens), com idades entre 30 e 83 anos (média de 59,2 anos). O tempo desde a radioterapia variou de 1 a 72 meses (média de 28 meses). A média da dose total de radiação recebida pelos pacientes foi de 5.955 cGy. O protocolo de avaliação consistiu de anamnese, exame físico, aferição do fluxo salivar estimulado e pHmetria da saliva. Os sintomas referidos foram boca seca (68%), disfagia (38%) e disgeusia (30%). Em 64% dos indivíduos o valor médio do fluxo salivar estimulado esteve abaixo de 0.7 ml/min. O pH médio da amostra foi de 6.97 (± 0.714). O fluxo estimulado e a ocorrência de candidíase atrófica aumentaram conforme o aumento do tempo pós-radioterapia (p < 0.05). A ocorrência de mucosite esteve associada a maiores doses de radiação (p < 0.05). Dois casos de segundo tumor primário foram diagnosticados. O principal efeito da radioterapia na região de cabeça e pescoço foi a redução do fluxo salivar, apesar de nosso estudo ter demonstrado que há uma melhora tardia do fluxo salivar. |
| first_indexed | 2024-12-13T22:23:03Z |
| format | Article |
| id | doaj.art-103d16dd260547d1afc9a2773750554b |
| institution | Directory Open Access Journal |
| issn | 1806-8324 |
| language | English |
| last_indexed | 2024-12-13T22:23:03Z |
| publishDate | 2007-09-01 |
| publisher | Sociedade Brasileira de Pesquisa Odontológica |
| record_format | Article |
| series | Brazilian Oral Research |
| spelling | doaj.art-103d16dd260547d1afc9a2773750554b2022-12-21T23:29:18ZengSociedade Brasileira de Pesquisa OdontológicaBrazilian Oral Research1806-83242007-09-0121327227710.1590/S1806-83242007000300014Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors Avaliação de algumas seqüelas bucais pós-radioterapia em pacientes tratados de neoplasias de cabeça e pescoçoCássia Maria Fischer RubiraNádia Juliana DevidesLiliane Torsani ÚbedaAntônio Geraldo Bortolucci JrJosé Roberto LaurisIzabel Regina Fischer Rubira-BullenJosé Humberto DamanteThe aim of this study was to evaluate the oral sequelae of radiotherapy in patients treated between 1999 and 2003 for head and neck tumors. One-hundred patients (24 women, 76 men) ranging in age from 30 to 83 years (mean 59.2 years) were examined. Time since radiotherapy ranged from 1 to 72 months (mean 28 months). The total mean radiation dose received by the patients was 5,955 cGy. The evaluation protocol included anamnesis, intraoral and extraoral examination, measurement of stimulated salivary flow and salivary pH. Symptoms reported by the patients included dry mouth (68%), dysphagia (38%), and dysgeusia (30%). In 64% of the patients, the mean stimulated salivary flow rate was less than 0.7 ml/min. The mean salivary pH was 6.97 (± 0.714). Stimulated salivary flow increased with increasing postradiotherapy time (p < 0.05). The prevalence of mucositis was associated with higher radiation doses (p < 0.05), and the prevalence of atrophic candidiasis was related to a longer post-treatment period (p < 0.05). Two cases of recurrence of the primary tumor were detected during the study. The main effect of radiotheraphy in the head and neck region was a reduction of the salivary flow rate, even though our study demonstrated that there was a modest late improvement of the salivary flow.<br>O objetivo deste estudo foi avaliar as seqüelas bucais provocadas pela radioterapia em pacientes com neoplasias de cabeça e pescoço, tratados entre 1999 e 2003. Foram examinados 100 pacientes (24 mulheres e 76 homens), com idades entre 30 e 83 anos (média de 59,2 anos). O tempo desde a radioterapia variou de 1 a 72 meses (média de 28 meses). A média da dose total de radiação recebida pelos pacientes foi de 5.955 cGy. O protocolo de avaliação consistiu de anamnese, exame físico, aferição do fluxo salivar estimulado e pHmetria da saliva. Os sintomas referidos foram boca seca (68%), disfagia (38%) e disgeusia (30%). Em 64% dos indivíduos o valor médio do fluxo salivar estimulado esteve abaixo de 0.7 ml/min. O pH médio da amostra foi de 6.97 (± 0.714). O fluxo estimulado e a ocorrência de candidíase atrófica aumentaram conforme o aumento do tempo pós-radioterapia (p < 0.05). A ocorrência de mucosite esteve associada a maiores doses de radiação (p < 0.05). Dois casos de segundo tumor primário foram diagnosticados. O principal efeito da radioterapia na região de cabeça e pescoço foi a redução do fluxo salivar, apesar de nosso estudo ter demonstrado que há uma melhora tardia do fluxo salivar.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242007000300014RadioterapiaXerostomiaSalivaNeoplasias de cabeça e pescoçoRadiotherapyXerostomiaSalivaHead and neck neoplasms |
| spellingShingle | Cássia Maria Fischer Rubira Nádia Juliana Devides Liliane Torsani Úbeda Antônio Geraldo Bortolucci Jr José Roberto Lauris Izabel Regina Fischer Rubira-Bullen José Humberto Damante Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors Avaliação de algumas seqüelas bucais pós-radioterapia em pacientes tratados de neoplasias de cabeça e pescoço Brazilian Oral Research Radioterapia Xerostomia Saliva Neoplasias de cabeça e pescoço Radiotherapy Xerostomia Saliva Head and neck neoplasms |
| title | Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors Avaliação de algumas seqüelas bucais pós-radioterapia em pacientes tratados de neoplasias de cabeça e pescoço |
| title_full | Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors Avaliação de algumas seqüelas bucais pós-radioterapia em pacientes tratados de neoplasias de cabeça e pescoço |
| title_fullStr | Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors Avaliação de algumas seqüelas bucais pós-radioterapia em pacientes tratados de neoplasias de cabeça e pescoço |
| title_full_unstemmed | Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors Avaliação de algumas seqüelas bucais pós-radioterapia em pacientes tratados de neoplasias de cabeça e pescoço |
| title_short | Evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors Avaliação de algumas seqüelas bucais pós-radioterapia em pacientes tratados de neoplasias de cabeça e pescoço |
| title_sort | evaluation of some oral postradiotherapy sequelae in patients treated for head and neck tumors avaliacao de algumas sequelas bucais pos radioterapia em pacientes tratados de neoplasias de cabeca e pescoco |
| topic | Radioterapia Xerostomia Saliva Neoplasias de cabeça e pescoço Radiotherapy Xerostomia Saliva Head and neck neoplasms |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242007000300014 |
| work_keys_str_mv | AT cassiamariafischerrubira evaluationofsomeoralpostradiotherapysequelaeinpatientstreatedforheadandnecktumorsavaliacaodealgumassequelasbucaisposradioterapiaempacientestratadosdeneoplasiasdecabecaepescoco AT nadiajulianadevides evaluationofsomeoralpostradiotherapysequelaeinpatientstreatedforheadandnecktumorsavaliacaodealgumassequelasbucaisposradioterapiaempacientestratadosdeneoplasiasdecabecaepescoco AT lilianetorsaniubeda evaluationofsomeoralpostradiotherapysequelaeinpatientstreatedforheadandnecktumorsavaliacaodealgumassequelasbucaisposradioterapiaempacientestratadosdeneoplasiasdecabecaepescoco AT antoniogeraldobortoluccijr evaluationofsomeoralpostradiotherapysequelaeinpatientstreatedforheadandnecktumorsavaliacaodealgumassequelasbucaisposradioterapiaempacientestratadosdeneoplasiasdecabecaepescoco AT joserobertolauris evaluationofsomeoralpostradiotherapysequelaeinpatientstreatedforheadandnecktumorsavaliacaodealgumassequelasbucaisposradioterapiaempacientestratadosdeneoplasiasdecabecaepescoco AT izabelreginafischerrubirabullen evaluationofsomeoralpostradiotherapysequelaeinpatientstreatedforheadandnecktumorsavaliacaodealgumassequelasbucaisposradioterapiaempacientestratadosdeneoplasiasdecabecaepescoco AT josehumbertodamante evaluationofsomeoralpostradiotherapysequelaeinpatientstreatedforheadandnecktumorsavaliacaodealgumassequelasbucaisposradioterapiaempacientestratadosdeneoplasiasdecabecaepescoco |