Type 2 Diabetes and Risk of Early-Onset Colorectal Cancer
Background and Aims: Early-onset colorectal cancer (CRC) is increasing in many developed countries. Type 2 diabetes mellitus has increased substantially in younger adults; however, its role in early-onset CRC remains unidentified. Methods: We conducted a claims-based nested case-control study using...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Gastro Hep Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572321000273 |
| _version_ | 1819061959890305024 |
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| author | Zitong Li Hanyu Chen Cassandra D.L. Fritz Xiaobin Zheng Xiaoyu Zong Katelin B. Nickel Andrew Tipping Long H. Nguyen Andrew T. Chan Edward L. Giovannucci Graham A. Colditz Margaret A. Olsen Peter T. Campbell Nicholas O. Davidson Ryan C. Fields Yin Cao |
| author_facet | Zitong Li Hanyu Chen Cassandra D.L. Fritz Xiaobin Zheng Xiaoyu Zong Katelin B. Nickel Andrew Tipping Long H. Nguyen Andrew T. Chan Edward L. Giovannucci Graham A. Colditz Margaret A. Olsen Peter T. Campbell Nicholas O. Davidson Ryan C. Fields Yin Cao |
| author_sort | Zitong Li |
| collection | DOAJ |
| description | Background and Aims: Early-onset colorectal cancer (CRC) is increasing in many developed countries. Type 2 diabetes mellitus has increased substantially in younger adults; however, its role in early-onset CRC remains unidentified. Methods: We conducted a claims-based nested case-control study using IBM MarketScan Commercial Database (2006–2015). Incident early-onset CRC diagnosed at ages 18–49 was identified by the International Classification of Diseases, ninth Revision, Clinical Modification diagnosis code, and the first coded diagnostic pathology date was assigned as the index date. Controls were frequency matched with cases. Type 2 diabetes, stratified by severity, was identified through International Classification of Diseases, ninth Revision, Clinical Modification using the Klabunde algorithm. Multivariable logistic regressions were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 6001 early-onset CRC and 52,104 controls were included. Type 2 diabetes was associated with an increased risk of early-onset CRC (5.0% in cases vs 3.7% in controls; OR = 1.24, 95% CI: 1.09–1.41). The positive association was more pronounced for uncontrolled (OR = 1.37; 95% CI: 1.12–1.67) or complicated (OR = 1.59, 95% CI: 1.08–2.35) type 2 diabetes compared with controlled diabetes (OR = 1.13, 95% CI: 0.94–1.36). Conclusion: Individuals with type 2 diabetes have a higher risk of early-onset CRC, with stronger associations for uncontrolled diabetes and complicated diabetes. The rising prevalence of type 2 diabetes among younger adults may partially contribute to the increasing incidence of early-onset CRC. |
| first_indexed | 2024-12-21T14:51:11Z |
| format | Article |
| id | doaj.art-103fd8a9be5e4fc8b2e9e6f94c5b2e11 |
| institution | Directory Open Access Journal |
| issn | 2772-5723 |
| language | English |
| last_indexed | 2024-12-21T14:51:11Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj.art-103fd8a9be5e4fc8b2e9e6f94c5b2e112022-12-21T18:59:53ZengElsevierGastro Hep Advances2772-57232022-01-0112186193Type 2 Diabetes and Risk of Early-Onset Colorectal CancerZitong Li0Hanyu Chen1Cassandra D.L. Fritz2Xiaobin Zheng3Xiaoyu Zong4Katelin B. Nickel5Andrew Tipping6Long H. Nguyen7Andrew T. Chan8Edward L. Giovannucci9Graham A. Colditz10Margaret A. Olsen11Peter T. Campbell12Nicholas O. Davidson13Ryan C. Fields14Yin Cao15Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MissouriDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MissouriDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MissouriDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MissouriDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MissouriDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St Louis, MissouriDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St Louis, MissouriDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MassachusettsDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MassachusettsDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MassachusettsDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MissouriDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St Louis, MissouriDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New YorkDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MissouriAlvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri; Department of Surgery, Washington University School of Medicine, St. Louis, MissouriDivision of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri; Correspondence: Address correspondence to: Yin Cao, MPH, ScD, Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8100, St. Louis, Missouri 63110.Background and Aims: Early-onset colorectal cancer (CRC) is increasing in many developed countries. Type 2 diabetes mellitus has increased substantially in younger adults; however, its role in early-onset CRC remains unidentified. Methods: We conducted a claims-based nested case-control study using IBM MarketScan Commercial Database (2006–2015). Incident early-onset CRC diagnosed at ages 18–49 was identified by the International Classification of Diseases, ninth Revision, Clinical Modification diagnosis code, and the first coded diagnostic pathology date was assigned as the index date. Controls were frequency matched with cases. Type 2 diabetes, stratified by severity, was identified through International Classification of Diseases, ninth Revision, Clinical Modification using the Klabunde algorithm. Multivariable logistic regressions were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 6001 early-onset CRC and 52,104 controls were included. Type 2 diabetes was associated with an increased risk of early-onset CRC (5.0% in cases vs 3.7% in controls; OR = 1.24, 95% CI: 1.09–1.41). The positive association was more pronounced for uncontrolled (OR = 1.37; 95% CI: 1.12–1.67) or complicated (OR = 1.59, 95% CI: 1.08–2.35) type 2 diabetes compared with controlled diabetes (OR = 1.13, 95% CI: 0.94–1.36). Conclusion: Individuals with type 2 diabetes have a higher risk of early-onset CRC, with stronger associations for uncontrolled diabetes and complicated diabetes. The rising prevalence of type 2 diabetes among younger adults may partially contribute to the increasing incidence of early-onset CRC.http://www.sciencedirect.com/science/article/pii/S2772572321000273DiabetesColorectal CancerEarly-onsetEpidemiology |
| spellingShingle | Zitong Li Hanyu Chen Cassandra D.L. Fritz Xiaobin Zheng Xiaoyu Zong Katelin B. Nickel Andrew Tipping Long H. Nguyen Andrew T. Chan Edward L. Giovannucci Graham A. Colditz Margaret A. Olsen Peter T. Campbell Nicholas O. Davidson Ryan C. Fields Yin Cao Type 2 Diabetes and Risk of Early-Onset Colorectal Cancer Gastro Hep Advances Diabetes Colorectal Cancer Early-onset Epidemiology |
| title | Type 2 Diabetes and Risk of Early-Onset Colorectal Cancer |
| title_full | Type 2 Diabetes and Risk of Early-Onset Colorectal Cancer |
| title_fullStr | Type 2 Diabetes and Risk of Early-Onset Colorectal Cancer |
| title_full_unstemmed | Type 2 Diabetes and Risk of Early-Onset Colorectal Cancer |
| title_short | Type 2 Diabetes and Risk of Early-Onset Colorectal Cancer |
| title_sort | type 2 diabetes and risk of early onset colorectal cancer |
| topic | Diabetes Colorectal Cancer Early-onset Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S2772572321000273 |
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