Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice
Nagata, Utsumi, Asaka, Maeda et al. describe a nanobody, TP86, that potently neutralizes both BA.1 and BA.2 Omicron SARS-CoV-2 variants, and, when combined with the TP17 nanobody, broadly neutralizes all SARS-CoV-2 variants. This nanobody cocktail also suppresses weight loss and prolongs survival of...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Communications Medicine |
| Online Access: | https://doi.org/10.1038/s43856-022-00213-5 |
| _version_ | 1828281032313405440 |
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| author | Kayoko Nagata Daichi Utsumi Masamitsu N. Asaka Ryota Maeda Kotaro Shirakawa Yasuhiro Kazuma Ryosuke Nomura Yoshihito Horisawa Yohei Yanagida Yugo Kawai Kei Sato Yutaro Yamaoka Kei Miyakawa Akihide Ryo Yasuhiro Yasutomi Akihiro Imura Akifumi Takaori-Kondo |
| author_facet | Kayoko Nagata Daichi Utsumi Masamitsu N. Asaka Ryota Maeda Kotaro Shirakawa Yasuhiro Kazuma Ryosuke Nomura Yoshihito Horisawa Yohei Yanagida Yugo Kawai Kei Sato Yutaro Yamaoka Kei Miyakawa Akihide Ryo Yasuhiro Yasutomi Akihiro Imura Akifumi Takaori-Kondo |
| author_sort | Kayoko Nagata |
| collection | DOAJ |
| description | Nagata, Utsumi, Asaka, Maeda et al. describe a nanobody, TP86, that potently neutralizes both BA.1 and BA.2 Omicron SARS-CoV-2 variants, and, when combined with the TP17 nanobody, broadly neutralizes all SARS-CoV-2 variants. This nanobody cocktail also suppresses weight loss and prolongs survival of SARS-CoV-2 infected human ACE2 transgenic mice. |
| first_indexed | 2024-04-13T08:08:43Z |
| format | Article |
| id | doaj.art-10418e3e410846ef990c3a56f313ff36 |
| institution | Directory Open Access Journal |
| issn | 2730-664X |
| language | English |
| last_indexed | 2024-04-13T08:08:43Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Medicine |
| spelling | doaj.art-10418e3e410846ef990c3a56f313ff362022-12-22T02:55:04ZengNature PortfolioCommunications Medicine2730-664X2022-11-01211610.1038/s43856-022-00213-5Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected miceKayoko Nagata0Daichi Utsumi1Masamitsu N. Asaka2Ryota Maeda3Kotaro Shirakawa4Yasuhiro Kazuma5Ryosuke Nomura6Yoshihito Horisawa7Yohei Yanagida8Yugo Kawai9Kei Sato10Yutaro Yamaoka11Kei Miyakawa12Akihide Ryo13Yasuhiro Yasutomi14Akihiro Imura15Akifumi Takaori-Kondo16Department of Hematology and Oncology, Graduate School of Medicine, Kyoto UniversityTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and NutritionTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and NutritionCOGNANO Inc.Department of Hematology and Oncology, Graduate School of Medicine, Kyoto UniversityDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto UniversityDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto UniversityDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto UniversityDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto UniversityDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto UniversityDivision of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of TokyoDepartment of Microbiology and Molecular Biodefense Research, Yokohama City University Graduate School of MedicineDepartment of Microbiology and Molecular Biodefense Research, Yokohama City University Graduate School of MedicineDepartment of Microbiology and Molecular Biodefense Research, Yokohama City University Graduate School of MedicineTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and NutritionCOGNANO Inc.Department of Hematology and Oncology, Graduate School of Medicine, Kyoto UniversityNagata, Utsumi, Asaka, Maeda et al. describe a nanobody, TP86, that potently neutralizes both BA.1 and BA.2 Omicron SARS-CoV-2 variants, and, when combined with the TP17 nanobody, broadly neutralizes all SARS-CoV-2 variants. This nanobody cocktail also suppresses weight loss and prolongs survival of SARS-CoV-2 infected human ACE2 transgenic mice.https://doi.org/10.1038/s43856-022-00213-5 |
| spellingShingle | Kayoko Nagata Daichi Utsumi Masamitsu N. Asaka Ryota Maeda Kotaro Shirakawa Yasuhiro Kazuma Ryosuke Nomura Yoshihito Horisawa Yohei Yanagida Yugo Kawai Kei Sato Yutaro Yamaoka Kei Miyakawa Akihide Ryo Yasuhiro Yasutomi Akihiro Imura Akifumi Takaori-Kondo Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice Communications Medicine |
| title | Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice |
| title_full | Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice |
| title_fullStr | Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice |
| title_full_unstemmed | Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice |
| title_short | Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice |
| title_sort | intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of sars cov 2 infected mice |
| url | https://doi.org/10.1038/s43856-022-00213-5 |
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