Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice

Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice

Nagata, Utsumi, Asaka, Maeda et al. describe a nanobody, TP86, that potently neutralizes both BA.1 and BA.2 Omicron SARS-CoV-2 variants, and, when combined with the TP17 nanobody, broadly neutralizes all SARS-CoV-2 variants. This nanobody cocktail also suppresses weight loss and prolongs survival of...

Full description

Bibliographic Details
Main Authors:	Kayoko Nagata, Daichi Utsumi, Masamitsu N. Asaka, Ryota Maeda, Kotaro Shirakawa, Yasuhiro Kazuma, Ryosuke Nomura, Yoshihito Horisawa, Yohei Yanagida, Yugo Kawai, Kei Sato, Yutaro Yamaoka, Kei Miyakawa, Akihide Ryo, Yasuhiro Yasutomi, Akihiro Imura, Akifumi Takaori-Kondo
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-11-01
Series:	Communications Medicine
Online Access:	https://doi.org/10.1038/s43856-022-00213-5

Similar Items

A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron
by: Ryota Maeda, et al.
Published: (2022-07-01)

APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression.
by: Hiroyuki Yamazaki, et al.
Published: (2020-01-01)

Highly susceptible SARS-CoV-2 model in CAG promoter–driven hACE2-transgenic mice
by: Masamitsu N. Asaka, et al.
Published: (2021-10-01)

Prime-boost-type PspA3 + 2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci
by: Chieko Yokota, et al.
Published: (2023-11-01)

Development of a Monoclonal Antibody Targeting HTLV-1 Envelope gp46 Glycoprotein and Its Application to Near-Infrared Photoimmuno-Antimicrobial Strategy
by: Yasuyoshi Hatayama, et al.
Published: (2022-09-01)

Long-term protective immunity induced by an adjuvant-containing live-attenuated AIDS virus
by: Tomotaka Okamura, et al.
Published: (2021-10-01)

Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability
by: Jason Gorman, et al.
Published: (2024-01-01)

Inflammogenic effect of polyacrylic acid in rat lung following intratracheal instillation
by: Chinatsu Nishida, et al.
Published: (2022-01-01)

Enhanced Conformational Sampling of Nanobody CDR H3 Loop by Generalized Replica-Exchange with Solute Tempering
by: Ren Higashida, et al.
Published: (2021-12-01)

Management of airway in intratracheal tumour surgery
by: Upadhyayula Srinivas, et al.
Published: (2015-01-01)

BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction.
by: Kei Miyakawa, et al.
Published: (2009-12-01)

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers
by: Kathrin Koch, et al.
Published: (2017-08-01)

Characterization and Utilization of Disulfide-Bonded SARS-CoV-2 Receptor Binding Domain of Spike Protein Synthesized by Wheat Germ Cell-Free Production System
by: Yutaro Yamaoka, et al.
Published: (2022-07-01)

Effect of Different Molecular Weights of Polyacrylic Acid on Rat Lung Following Intratracheal Instillation
by: Chinatsu Nishida, et al.
Published: (2022-09-01)

Anesthetic management for successful removal of intratracheal tumor
by: Garg Suneel, et al.
Published: (2011-01-01)

Cocktails : 101 cocktails to make and enjoy /
by: Effeny, Paul
Published: (2002)

Development of Monoclonal Antibodies and Antigen-Capture ELISA for Human Parechovirus Type 3
by: Keiko Goto, et al.
Published: (2020-09-01)

Prolyl Isomerase Pin1 Regulates the Stability of Hepatitis B Virus Core Protein
by: Mayuko Nishi, et al.
Published: (2020-01-01)

HTRA1 Mutations Identified in Symptomatic Carriers Have the Property of Interfering the Trimer-Dependent Activation Cascade
by: Masahiro Uemura, et al.
Published: (2019-06-01)

Difference in carcinogenicities of two different vapor grown carbon fibers with different physicochemical characteristics induced by intratracheal instillation in rats
by: Kei Sato, et al.
Published: (2023-09-01)

Cocktails /
by: 204712 Butler, James, et al.
Published: (2007)

Al-water fed chemically augmented DC arcjet characteristics
by: Yanagida, Naoto, et al.
Published: (2015)

Flexible-Imaging-Fiber-Guided Intratracheal Intubation in Rodents
by: Sang Hoon Jeong, et al.
Published: (2023-03-01)

Effects of Intratracheal Suctioning on Hemodynamic Parameters and Arterial Oxygen
by: Shahram Etemadifar, et al.
Published: (2008-11-01)

Anesthetic management for bronchoscopy and debulking of obstructing intratracheal tumor
by: B Uma, et al.
Published: (2015-01-01)

Electrophysiological and biochemical response in rats on intratracheal instillation of manganese
by: Máté Zsuzsanna, et al.
Published: (2011-12-01)

All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity
by: Takeshi Morita, et al.
Published: (2021-08-01)

Corrigendum: HTRA1 Mutations Identified in Symptomatic Carriers Have the Property of Interfering the Trimer-Dependent Activation Cascade
by: Masahiro Uemura, et al.
Published: (2021-09-01)

MAL Inhibits the Production of HIV-1 Particles by Sequestering Gag to Intracellular Endosomal Compartments
by: Kei Miyakawa, et al.
Published: (2022-03-01)

Development of a contacting transwell co-culture system for the in vitro propagation of primary central nervous system lymphoma
by: Mayuko Nishi, et al.
Published: (2023-11-01)

Prediction models for neutralization activity against emerging SARS-CoV-2 variants: A cross-sectional study
by: Atsushi Goto, et al.
Published: (2023-04-01)

The Effects of Endoplasmic Reticulum Stress via Intratracheal Instillation of Water-Soluble Acrylic Acid Polymer on the Lungs of Rats
by: Toshiki Morimoto, et al.
Published: (2024-03-01)

Generation and Utilization of a Monoclonal Antibody against Hepatitis B Virus Core Protein for a Comprehensive Interactome Analysis
by: Yusuke Nakai, et al.
Published: (2022-11-01)

Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics
by: Peter Bannas, et al.
Published: (2017-11-01)

Futurist cocktails
by: Spence, C
Published: (2017)

Cocktails and snacks /
by: Piper, Beverley, et al.
Published: (1987)

500 cocktails :
by: 353505 Sweetser, Wendy
Published: (c200)

The cocktail handbook /
by: 387590 Costantino, Maria
Published: (2001)

Obstructive Fibrinous Tracheal Pseudomembrane Following Repeated Intratracheal Interventions
by: Tang W, et al.
Published: (2024-03-01)

A Noninvasive Intratracheal Inoculation Method for the Study of Pulmonary Melioidosis
by: David Aaron Revelli, et al.
Published: (2012-12-01)