Diagnosis and treatment of botulism after botulinum toxin type A injections: report of 9 cases
Objective To explore the diagnostic criteria of botulism after botulinum toxin type A (BT/A) injection and observe the therapeutic effect of botulinum antitoxin. Methods From August 2018 to June 2020, 9 patients suffering from botulism after BT/A injection admitted to our department were enrolled in...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Third Military Medical University
2021-09-01
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| Series: | Di-san junyi daxue xuebao |
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| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/202103069.htm |
| _version_ | 1818601886051205120 |
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| author | HE Ping ZHANG Jianghe YAN Rongshuai FAN Dongli WANG Shaoliang MAO Tongchun |
| author_facet | HE Ping ZHANG Jianghe YAN Rongshuai FAN Dongli WANG Shaoliang MAO Tongchun |
| author_sort | HE Ping |
| collection | DOAJ |
| description | Objective To explore the diagnostic criteria of botulism after botulinum toxin type A (BT/A) injection and observe the therapeutic effect of botulinum antitoxin. Methods From August 2018 to June 2020, 9 patients suffering from botulism after BT/A injection admitted to our department were enrolled in this study. They all received blood laboratory examinations, electrophysiological examination, ophthalmological examination and so on, and then, were treated with botulinum antitoxin (type A). Results Toxic granules in the neutrophils were found in the peripheral blood smears of these patients. The results of electrophysiological examination showed that there were prolongation of motor nerve conduction velocity (MCV) in 1 patient, prolongation of trigeminal somatosensory evoked potential (TSEP) in 1 patient, attenuation of repetitive nerve stimulation (RNS) in 2 patients and prolongation of visual evoked potential (VEP) in 1 patient. In ophthalmological examination, the double view was positive in 2 cases, and the eyelid plate gland was less in 2 cases. Nine patients were treated with botulinum antitoxin and recovered well after that. Conclusion Combined with clinical manifestations, comprehensive blood laboratory examinations, electrophysiological examination and ophthalmological examination are helpful for the early diagnosis and elimination of botulism. Patients with confirmed botulinum should be treated with botulinum antitoxin as soon as possible. |
| first_indexed | 2024-12-16T12:58:30Z |
| format | Article |
| id | doaj.art-1043a48510f9439b8519a8204e207833 |
| institution | Directory Open Access Journal |
| issn | 1000-5404 |
| language | zho |
| last_indexed | 2024-12-16T12:58:30Z |
| publishDate | 2021-09-01 |
| publisher | Editorial Office of Journal of Third Military Medical University |
| record_format | Article |
| series | Di-san junyi daxue xuebao |
| spelling | doaj.art-1043a48510f9439b8519a8204e2078332022-12-21T22:30:55ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042021-09-0143171684168810.16016/j.1000-5404.202103069Diagnosis and treatment of botulism after botulinum toxin type A injections: report of 9 casesHE Ping0ZHANG Jianghe1YAN Rongshuai2 FAN Dongli3WANG Shaoliang4MAO Tongchun5Department of Plastic and Cosmetic Surgery, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, ChinaDepartment of Plastic and Cosmetic Surgery, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, ChinaDepartment of Plastic and Cosmetic Surgery, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, ChinaDepartment of Plastic and Cosmetic Surgery, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, ChinaDepartment of Plastic and Cosmetic Surgery, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, ChinaDepartment of Plastic and Cosmetic Surgery, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, ChinaObjective To explore the diagnostic criteria of botulism after botulinum toxin type A (BT/A) injection and observe the therapeutic effect of botulinum antitoxin. Methods From August 2018 to June 2020, 9 patients suffering from botulism after BT/A injection admitted to our department were enrolled in this study. They all received blood laboratory examinations, electrophysiological examination, ophthalmological examination and so on, and then, were treated with botulinum antitoxin (type A). Results Toxic granules in the neutrophils were found in the peripheral blood smears of these patients. The results of electrophysiological examination showed that there were prolongation of motor nerve conduction velocity (MCV) in 1 patient, prolongation of trigeminal somatosensory evoked potential (TSEP) in 1 patient, attenuation of repetitive nerve stimulation (RNS) in 2 patients and prolongation of visual evoked potential (VEP) in 1 patient. In ophthalmological examination, the double view was positive in 2 cases, and the eyelid plate gland was less in 2 cases. Nine patients were treated with botulinum antitoxin and recovered well after that. Conclusion Combined with clinical manifestations, comprehensive blood laboratory examinations, electrophysiological examination and ophthalmological examination are helpful for the early diagnosis and elimination of botulism. Patients with confirmed botulinum should be treated with botulinum antitoxin as soon as possible.http://aammt.tmmu.edu.cn/Upload/rhtml/202103069.htmbotulinum a toxinpoisoningbotulinum antitoxin |
| spellingShingle | HE Ping ZHANG Jianghe YAN Rongshuai FAN Dongli WANG Shaoliang MAO Tongchun Diagnosis and treatment of botulism after botulinum toxin type A injections: report of 9 cases Di-san junyi daxue xuebao botulinum a toxin poisoning botulinum antitoxin |
| title | Diagnosis and treatment of botulism after botulinum toxin type A injections: report of 9 cases |
| title_full | Diagnosis and treatment of botulism after botulinum toxin type A injections: report of 9 cases |
| title_fullStr | Diagnosis and treatment of botulism after botulinum toxin type A injections: report of 9 cases |
| title_full_unstemmed | Diagnosis and treatment of botulism after botulinum toxin type A injections: report of 9 cases |
| title_short | Diagnosis and treatment of botulism after botulinum toxin type A injections: report of 9 cases |
| title_sort | diagnosis and treatment of botulism after botulinum toxin type a injections report of 9 cases |
| topic | botulinum a toxin poisoning botulinum antitoxin |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/202103069.htm |
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