Current apparent treatment‐resistant hypertension in patients undergoing peritoneal dialysis: A multi‐center cross‐sectional study
Abstract Apparent treatment‐resistant hypertension (aTRH) is the most commonly used term to report resistant hypertension (RH) and is considered as a common problem in dialysis population. However, few reports have focused on peritoneal dialysis (PD) hypertensive patients. The authors conducted a mu...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-04-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14455 |
| _version_ | 1797645138955075584 |
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| author | Dan Li Zhihao Huo Danyang Liu Nirong Gong Fen Zhang Yaozhong Kong Yunfang Zhang Xiaoyan Su Qingdong Xu Jiexia Feng Fuzhang Luo Cheng Wang Xianrui Dou Guohui Sun Difei Zhang Xianhui Qin Guangqing Zhang Fuhua Lu Jun Ai |
| author_facet | Dan Li Zhihao Huo Danyang Liu Nirong Gong Fen Zhang Yaozhong Kong Yunfang Zhang Xiaoyan Su Qingdong Xu Jiexia Feng Fuzhang Luo Cheng Wang Xianrui Dou Guohui Sun Difei Zhang Xianhui Qin Guangqing Zhang Fuhua Lu Jun Ai |
| author_sort | Dan Li |
| collection | DOAJ |
| description | Abstract Apparent treatment‐resistant hypertension (aTRH) is the most commonly used term to report resistant hypertension (RH) and is considered as a common problem in dialysis population. However, few reports have focused on peritoneal dialysis (PD) hypertensive patients. The authors conducted a multi‐center cross‐sectional study involving 1789 PD patients from nine centers in Guangdong, China. The prevalence of aTRH was estimated by home blood pressure (BP) monitoring. Evaluating drug adherence through Eight‐item Morisky Medication Adherence Scale (MMAS‐8) and pill counting was performed to assess RH in one PD center. Related factors of aTRH were analyzed using logistic regression analysis. The prevalence of aTRH in PD patients was estimated at 42.2% (755 out of 1789 hypertensive patients) based on home BP. Of those, 91.4% patients were classified as uncontrolled RH, 2.0% as controlled RH, and 6.6% as refractory hypertension. The prevalence of RH was 40.6% and 41.9% among those with medium/high adherence based on the MMAS‐8 scores and the pill counting rate, respectively. PD patients who were younger, with higher body mass index, with lower serum albumin and poorer dialysis adequacy were significantly associated with higher aTRH incident. In conclusion, the present study demonstrates a high prevalence of aTRH in PD population, which occurs in about two in five treated hypertensive patients. Nutritional status and dialysis adequacy might tightly associate with aTRH. |
| first_indexed | 2024-03-11T14:41:47Z |
| format | Article |
| id | doaj.art-10443c5533814badafd75155ac8bc9d2 |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:41:47Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-10443c5533814badafd75155ac8bc9d22023-10-30T13:26:43ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762022-04-0124449350110.1111/jch.14455Current apparent treatment‐resistant hypertension in patients undergoing peritoneal dialysis: A multi‐center cross‐sectional studyDan Li0Zhihao Huo1Danyang Liu2Nirong Gong3Fen Zhang4Yaozhong Kong5Yunfang Zhang6Xiaoyan Su7Qingdong Xu8Jiexia Feng9Fuzhang Luo10Cheng Wang11Xianrui Dou12Guohui Sun13Difei Zhang14Xianhui Qin15Guangqing Zhang16Fuhua Lu17Jun Ai18State Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Division of Nephrology Nanfang Hospital Southern Medical University Guangzhou PR ChinaState Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Division of Nephrology Nanfang Hospital Southern Medical University Guangzhou PR ChinaState Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Division of Nephrology Nanfang Hospital Southern Medical University Guangzhou PR ChinaState Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Division of Nephrology Nanfang Hospital Southern Medical University Guangzhou PR ChinaState Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Division of Nephrology Nanfang Hospital Southern Medical University Guangzhou PR ChinaNephrology Department The First People's Hospital of Foshan Foshan PR ChinaDepartment of Nephrology Affiliated Huadu Hospital Southern Medical University Guangzhou PR ChinaDepartment of Nephrology Tungwah Hospital Sun Yat‐sen University Dongguan PR ChinaDepartment of Nephrology Jiangmen Central Hospital Affiliated Jiangmen Hospital of Sun Yat‐sen University Jiangmen PR ChinaDepartment of Nephrology Jiangmen Central Hospital Affiliated Jiangmen Hospital of Sun Yat‐sen University Jiangmen PR ChinaDivision of Nephrology Nanhai District People's Hospital of Foshan Foshan PR ChinaDivision of Nephrology Department of Medicine The Fifth Affiliated Hospital of Sun Yat‐Sen University Zhuhai PR ChinaDepartment of Nephrology Shunde Hospital Southern Medical University Foshan PR ChinaDepartment of Nephrology Zengcheng Branch of Nanfang Hospital Southern Medical University Guangzhou PR ChinaDepartment of Nephrology Guangdong Provincial Hospital of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou PR ChinaState Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Division of Nephrology Nanfang Hospital Southern Medical University Guangzhou PR ChinaAdministrative Office Nanfang Hospital Southern Medical University Guangzhou PR ChinaDepartment of Nephrology Guangdong Provincial Hospital of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou PR ChinaState Key Laboratory of Organ Failure Research National Clinical Research Center of Kidney Disease Division of Nephrology Nanfang Hospital Southern Medical University Guangzhou PR ChinaAbstract Apparent treatment‐resistant hypertension (aTRH) is the most commonly used term to report resistant hypertension (RH) and is considered as a common problem in dialysis population. However, few reports have focused on peritoneal dialysis (PD) hypertensive patients. The authors conducted a multi‐center cross‐sectional study involving 1789 PD patients from nine centers in Guangdong, China. The prevalence of aTRH was estimated by home blood pressure (BP) monitoring. Evaluating drug adherence through Eight‐item Morisky Medication Adherence Scale (MMAS‐8) and pill counting was performed to assess RH in one PD center. Related factors of aTRH were analyzed using logistic regression analysis. The prevalence of aTRH in PD patients was estimated at 42.2% (755 out of 1789 hypertensive patients) based on home BP. Of those, 91.4% patients were classified as uncontrolled RH, 2.0% as controlled RH, and 6.6% as refractory hypertension. The prevalence of RH was 40.6% and 41.9% among those with medium/high adherence based on the MMAS‐8 scores and the pill counting rate, respectively. PD patients who were younger, with higher body mass index, with lower serum albumin and poorer dialysis adequacy were significantly associated with higher aTRH incident. In conclusion, the present study demonstrates a high prevalence of aTRH in PD population, which occurs in about two in five treated hypertensive patients. Nutritional status and dialysis adequacy might tightly associate with aTRH.https://doi.org/10.1111/jch.14455apparent treatment‐resistant hypertensiondialysis adequacyhome blood pressure monitoringperitoneal dialysis |
| spellingShingle | Dan Li Zhihao Huo Danyang Liu Nirong Gong Fen Zhang Yaozhong Kong Yunfang Zhang Xiaoyan Su Qingdong Xu Jiexia Feng Fuzhang Luo Cheng Wang Xianrui Dou Guohui Sun Difei Zhang Xianhui Qin Guangqing Zhang Fuhua Lu Jun Ai Current apparent treatment‐resistant hypertension in patients undergoing peritoneal dialysis: A multi‐center cross‐sectional study The Journal of Clinical Hypertension apparent treatment‐resistant hypertension dialysis adequacy home blood pressure monitoring peritoneal dialysis |
| title | Current apparent treatment‐resistant hypertension in patients undergoing peritoneal dialysis: A multi‐center cross‐sectional study |
| title_full | Current apparent treatment‐resistant hypertension in patients undergoing peritoneal dialysis: A multi‐center cross‐sectional study |
| title_fullStr | Current apparent treatment‐resistant hypertension in patients undergoing peritoneal dialysis: A multi‐center cross‐sectional study |
| title_full_unstemmed | Current apparent treatment‐resistant hypertension in patients undergoing peritoneal dialysis: A multi‐center cross‐sectional study |
| title_short | Current apparent treatment‐resistant hypertension in patients undergoing peritoneal dialysis: A multi‐center cross‐sectional study |
| title_sort | current apparent treatment resistant hypertension in patients undergoing peritoneal dialysis a multi center cross sectional study |
| topic | apparent treatment‐resistant hypertension dialysis adequacy home blood pressure monitoring peritoneal dialysis |
| url | https://doi.org/10.1111/jch.14455 |
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