Cardiovascular Precision Medicine in the Genomics Era
Summary: Precision medicine strives to delineate disease using multiple data sources—from genomics to digital health metrics—in order to be more precise and accurate in our diagnoses, definitions, and treatments of disease subtypes. By defining disease at a deeper level, we can treat patients based...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-04-01
|
| Series: | JACC: Basic to Translational Science |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452302X18300081 |
| _version_ | 1818201980967845888 |
|---|---|
| author | Alexandra M. Dainis, BS Euan A. Ashley, BSc, MB ChB, DPhil |
| author_facet | Alexandra M. Dainis, BS Euan A. Ashley, BSc, MB ChB, DPhil |
| author_sort | Alexandra M. Dainis, BS |
| collection | DOAJ |
| description | Summary: Precision medicine strives to delineate disease using multiple data sources—from genomics to digital health metrics—in order to be more precise and accurate in our diagnoses, definitions, and treatments of disease subtypes. By defining disease at a deeper level, we can treat patients based on an understanding of the molecular underpinnings of their presentations, rather than grouping patients into broad categories with one-size-fits-all treatments. In this review, the authors examine how precision medicine, specifically that surrounding genetic testing and genetic therapeutics, has begun to make strides in both common and rare cardiovascular diseases in the clinic and the laboratory, and how these advances are beginning to enable us to more effectively define risk, diagnose disease, and deliver therapeutics for each individual patient. Key Words: genome sequencing, genomics, precision medicine, targeted therapeutics |
| first_indexed | 2024-12-12T03:02:11Z |
| format | Article |
| id | doaj.art-1046e3ab9b074ec1933875b270e87398 |
| institution | Directory Open Access Journal |
| issn | 2452-302X |
| language | English |
| last_indexed | 2024-12-12T03:02:11Z |
| publishDate | 2018-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JACC: Basic to Translational Science |
| spelling | doaj.art-1046e3ab9b074ec1933875b270e873982022-12-22T00:40:36ZengElsevierJACC: Basic to Translational Science2452-302X2018-04-0132313326Cardiovascular Precision Medicine in the Genomics EraAlexandra M. Dainis, BS0Euan A. Ashley, BSc, MB ChB, DPhil1Department of Genetics, Stanford University, Stanford, CaliforniaDepartment of Genetics, Stanford University, Stanford, California; Department of Medicine, Stanford University, Stanford, California; Stanford Center for Inherited Cardiovascular Disease, Stanford University, Stanford, California; Address for correspondence: Dr. Euan A. Ashley, Stanford Center for Inherited Cardiovascular Disease, Stanford University, 300 Pasteur Drive, CVRB Falk, Mail Code 5406, Stanford, California 94305.Summary: Precision medicine strives to delineate disease using multiple data sources—from genomics to digital health metrics—in order to be more precise and accurate in our diagnoses, definitions, and treatments of disease subtypes. By defining disease at a deeper level, we can treat patients based on an understanding of the molecular underpinnings of their presentations, rather than grouping patients into broad categories with one-size-fits-all treatments. In this review, the authors examine how precision medicine, specifically that surrounding genetic testing and genetic therapeutics, has begun to make strides in both common and rare cardiovascular diseases in the clinic and the laboratory, and how these advances are beginning to enable us to more effectively define risk, diagnose disease, and deliver therapeutics for each individual patient. Key Words: genome sequencing, genomics, precision medicine, targeted therapeuticshttp://www.sciencedirect.com/science/article/pii/S2452302X18300081 |
| spellingShingle | Alexandra M. Dainis, BS Euan A. Ashley, BSc, MB ChB, DPhil Cardiovascular Precision Medicine in the Genomics Era JACC: Basic to Translational Science |
| title | Cardiovascular Precision Medicine in the Genomics Era |
| title_full | Cardiovascular Precision Medicine in the Genomics Era |
| title_fullStr | Cardiovascular Precision Medicine in the Genomics Era |
| title_full_unstemmed | Cardiovascular Precision Medicine in the Genomics Era |
| title_short | Cardiovascular Precision Medicine in the Genomics Era |
| title_sort | cardiovascular precision medicine in the genomics era |
| url | http://www.sciencedirect.com/science/article/pii/S2452302X18300081 |
| work_keys_str_mv | AT alexandramdainisbs cardiovascularprecisionmedicineinthegenomicsera AT euanaashleybscmbchbdphil cardiovascularprecisionmedicineinthegenomicsera |