Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agents
Upconverting nanoparticles (UCNPs) are promising, new imaging probes capable of serving as multimodal contrast agents. In this study, monodisperse and ultrasmall core and core–shell UCNPs were synthesized via a thermal decomposition method. Furthermore, it was shown that the epitaxial growth of a Na...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2017-09-01
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| Series: | Beilstein Journal of Nanotechnology |
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| Online Access: | https://doi.org/10.3762/bjnano.8.183 |
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| author | Dovile Baziulyte-Paulaviciene Vitalijus Karabanovas Marius Stasys Greta Jarockyte Vilius Poderys Simas Sakirzanovas Ricardas Rotomskis |
| author_facet | Dovile Baziulyte-Paulaviciene Vitalijus Karabanovas Marius Stasys Greta Jarockyte Vilius Poderys Simas Sakirzanovas Ricardas Rotomskis |
| author_sort | Dovile Baziulyte-Paulaviciene |
| collection | DOAJ |
| description | Upconverting nanoparticles (UCNPs) are promising, new imaging probes capable of serving as multimodal contrast agents. In this study, monodisperse and ultrasmall core and core–shell UCNPs were synthesized via a thermal decomposition method. Furthermore, it was shown that the epitaxial growth of a NaGdF4 optical inert layer covering the NaGdF4:Yb,Er core effectively minimizes surface quenching due to the spatial isolation of the core from the surroundings. The mean diameter of the synthesized core and core–shell nanoparticles was ≈8 and ≈16 nm, respectively. Hydrophobic UCNPs were converted into hydrophilic ones using a nonionic surfactant Tween 80. The successful coating of the UCNPs by Tween 80 has been confirmed by Fourier transform infrared (FTIR) spectroscopy. Scanning electron microscopy (SEM), powder X-ray diffraction (XRD), photoluminescence (PL) spectra and magnetic resonance (MR) T1 relaxation measurements were used to characterize the size, crystal structure, optical and magnetic properties of the core and core–shell nanoparticles. Moreover, Tween 80-coated core–shell nanoparticles presented enhanced optical and MR signal intensity, good colloidal stability, low cytotoxicity and nonspecific internalization into two different breast cancer cell lines, which indicates that these nanoparticles could be applied as an efficient, dual-modal contrast probe for in vivo bioimaging. |
| first_indexed | 2024-12-18T23:13:10Z |
| format | Article |
| id | doaj.art-1047542a3e37429f97178cf8f24d2896 |
| institution | Directory Open Access Journal |
| issn | 2190-4286 |
| language | English |
| last_indexed | 2024-12-18T23:13:10Z |
| publishDate | 2017-09-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj.art-1047542a3e37429f97178cf8f24d28962022-12-21T20:48:18ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862017-09-01811815182410.3762/bjnano.8.1832190-4286-8-183Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agentsDovile Baziulyte-Paulaviciene0Vitalijus Karabanovas1Marius Stasys2Greta Jarockyte3Vilius Poderys4Simas Sakirzanovas5Ricardas Rotomskis6Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, Vilnius LT-03225, LithuaniaBiomedical Physics Laboratory, National Cancer Institute, Baublio str. 3b, Vilnius 2, LithuaniaBiomedical Physics Laboratory, National Cancer Institute, Baublio str. 3b, Vilnius 2, LithuaniaBiomedical Physics Laboratory, National Cancer Institute, Baublio str. 3b, Vilnius 2, LithuaniaBiomedical Physics Laboratory, National Cancer Institute, Baublio str. 3b, Vilnius 2, LithuaniaFaculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, Vilnius LT-03225, LithuaniaBiomedical Physics Laboratory, National Cancer Institute, Baublio str. 3b, Vilnius 2, LithuaniaUpconverting nanoparticles (UCNPs) are promising, new imaging probes capable of serving as multimodal contrast agents. In this study, monodisperse and ultrasmall core and core–shell UCNPs were synthesized via a thermal decomposition method. Furthermore, it was shown that the epitaxial growth of a NaGdF4 optical inert layer covering the NaGdF4:Yb,Er core effectively minimizes surface quenching due to the spatial isolation of the core from the surroundings. The mean diameter of the synthesized core and core–shell nanoparticles was ≈8 and ≈16 nm, respectively. Hydrophobic UCNPs were converted into hydrophilic ones using a nonionic surfactant Tween 80. The successful coating of the UCNPs by Tween 80 has been confirmed by Fourier transform infrared (FTIR) spectroscopy. Scanning electron microscopy (SEM), powder X-ray diffraction (XRD), photoluminescence (PL) spectra and magnetic resonance (MR) T1 relaxation measurements were used to characterize the size, crystal structure, optical and magnetic properties of the core and core–shell nanoparticles. Moreover, Tween 80-coated core–shell nanoparticles presented enhanced optical and MR signal intensity, good colloidal stability, low cytotoxicity and nonspecific internalization into two different breast cancer cell lines, which indicates that these nanoparticles could be applied as an efficient, dual-modal contrast probe for in vivo bioimaging.https://doi.org/10.3762/bjnano.8.183cancer theranosticscore–shell structureluminescencemultimodalnanoparticlesupconverting nanoparticlesupconversion |
| spellingShingle | Dovile Baziulyte-Paulaviciene Vitalijus Karabanovas Marius Stasys Greta Jarockyte Vilius Poderys Simas Sakirzanovas Ricardas Rotomskis Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agents Beilstein Journal of Nanotechnology cancer theranostics core–shell structure luminescence multimodal nanoparticles upconverting nanoparticles upconversion |
| title | Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agents |
| title_full | Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agents |
| title_fullStr | Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agents |
| title_full_unstemmed | Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agents |
| title_short | Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agents |
| title_sort | synthesis and functionalization of nagdf4 yb er nagdf4 core shell nanoparticles for possible application as multimodal contrast agents |
| topic | cancer theranostics core–shell structure luminescence multimodal nanoparticles upconverting nanoparticles upconversion |
| url | https://doi.org/10.3762/bjnano.8.183 |
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