Evaluation of choroidal thickness and retinal nerve fiber layer thickness in Chinese pregnant women and healthy non-pregnant women
Purpose: To evaluate choroidal thickness and retinal nerve fiber layer (RNFL) thickness in different trimesters using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: A prospective comparative study included 45 healthy pregnant women in the first trimester, 45 women in the sec...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Advances in Ophthalmology Practice and Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667376223000628 |
| _version_ | 1827312303038529536 |
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| author | Hanfei Wu Haishuang Lin Mengting Ruan Huanjie Fang Nannan Dong Tiewei Wang Feifei Yu Jiawei Zhao |
| author_facet | Hanfei Wu Haishuang Lin Mengting Ruan Huanjie Fang Nannan Dong Tiewei Wang Feifei Yu Jiawei Zhao |
| author_sort | Hanfei Wu |
| collection | DOAJ |
| description | Purpose: To evaluate choroidal thickness and retinal nerve fiber layer (RNFL) thickness in different trimesters using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: A prospective comparative study included 45 healthy pregnant women in the first trimester, 45 women in the second, 45 women in the third and 45 healthy non-pregnant women as the control group. Macular choroidal thickness was measured at three locations: The subfoveal, 1 mm temporal, and 1 mm nasal from the fovea with EDI-OCT. Peripapillary choroidal thickness (PPCT) and RNFL thickness parameters were automatically calculated by the Spectralis OCT. Results: The subfoveal, temporal and nasal macular choroidal thickness were all significantly thicker in the second trimester, compared with those parameters in the first, the third trimesters and the control group (all P < 0.05). The PPCT was significantly increased in the second trimeter compared with the control group at global, temporal, temporal inferior, nasal and nasal inferior positions (all P < 0.05). The RNFL thickness was also significantly increased in pregnant women at nasal superior and nasal inferior quadrants (all P < 0.05). Conclusions: The choroidal thickness in pregnant women was found to be thicker than the control group, regardless of macular or optic disc location. Findings of RNFL thickening might indicate subclinical involvement of the central nervous system. |
| first_indexed | 2024-03-08T20:09:46Z |
| format | Article |
| id | doaj.art-10485fab8bb44f2385d84841d32aaa20 |
| institution | Directory Open Access Journal |
| issn | 2667-3762 |
| language | English |
| last_indexed | 2024-04-24T21:40:08Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Ophthalmology Practice and Research |
| spelling | doaj.art-10485fab8bb44f2385d84841d32aaa202024-03-21T05:38:24ZengElsevierAdvances in Ophthalmology Practice and Research2667-37622024-02-0141813Evaluation of choroidal thickness and retinal nerve fiber layer thickness in Chinese pregnant women and healthy non-pregnant womenHanfei Wu0Haishuang Lin1Mengting Ruan2Huanjie Fang3Nannan Dong4Tiewei Wang5Feifei Yu6Jiawei Zhao7Department of Opthalmology, The People's Hospital of Zhuji, Shaoxing, Zhejiang, ChinaDepartment of Opthalmology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Obstetrics, The People's Hospital of Zhuji, Zhejiang, ChinaDepartment of Opthalmology, The People's Hospital of Zhuji, Shaoxing, Zhejiang, ChinaDepartment of Opthalmology, The People's Hospital of Zhuji, Shaoxing, Zhejiang, ChinaDepartment of Opthalmology, The People's Hospital of Zhuji, Shaoxing, Zhejiang, ChinaDepartment of Opthalmology, The People's Hospital of Zhuji, Shaoxing, Zhejiang, ChinaDepartment of Opthalmology, The People's Hospital of Zhuji, Shaoxing, Zhejiang, China; Corresponding author.Purpose: To evaluate choroidal thickness and retinal nerve fiber layer (RNFL) thickness in different trimesters using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: A prospective comparative study included 45 healthy pregnant women in the first trimester, 45 women in the second, 45 women in the third and 45 healthy non-pregnant women as the control group. Macular choroidal thickness was measured at three locations: The subfoveal, 1 mm temporal, and 1 mm nasal from the fovea with EDI-OCT. Peripapillary choroidal thickness (PPCT) and RNFL thickness parameters were automatically calculated by the Spectralis OCT. Results: The subfoveal, temporal and nasal macular choroidal thickness were all significantly thicker in the second trimester, compared with those parameters in the first, the third trimesters and the control group (all P < 0.05). The PPCT was significantly increased in the second trimeter compared with the control group at global, temporal, temporal inferior, nasal and nasal inferior positions (all P < 0.05). The RNFL thickness was also significantly increased in pregnant women at nasal superior and nasal inferior quadrants (all P < 0.05). Conclusions: The choroidal thickness in pregnant women was found to be thicker than the control group, regardless of macular or optic disc location. Findings of RNFL thickening might indicate subclinical involvement of the central nervous system.http://www.sciencedirect.com/science/article/pii/S2667376223000628ChoroidRetinal nerve fiber layerOptical coherence tomographyPregnancy |
| spellingShingle | Hanfei Wu Haishuang Lin Mengting Ruan Huanjie Fang Nannan Dong Tiewei Wang Feifei Yu Jiawei Zhao Evaluation of choroidal thickness and retinal nerve fiber layer thickness in Chinese pregnant women and healthy non-pregnant women Advances in Ophthalmology Practice and Research Choroid Retinal nerve fiber layer Optical coherence tomography Pregnancy |
| title | Evaluation of choroidal thickness and retinal nerve fiber layer thickness in Chinese pregnant women and healthy non-pregnant women |
| title_full | Evaluation of choroidal thickness and retinal nerve fiber layer thickness in Chinese pregnant women and healthy non-pregnant women |
| title_fullStr | Evaluation of choroidal thickness and retinal nerve fiber layer thickness in Chinese pregnant women and healthy non-pregnant women |
| title_full_unstemmed | Evaluation of choroidal thickness and retinal nerve fiber layer thickness in Chinese pregnant women and healthy non-pregnant women |
| title_short | Evaluation of choroidal thickness and retinal nerve fiber layer thickness in Chinese pregnant women and healthy non-pregnant women |
| title_sort | evaluation of choroidal thickness and retinal nerve fiber layer thickness in chinese pregnant women and healthy non pregnant women |
| topic | Choroid Retinal nerve fiber layer Optical coherence tomography Pregnancy |
| url | http://www.sciencedirect.com/science/article/pii/S2667376223000628 |
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