Sonidegib, a Novel Inhibitor of Suicidal Erythrocyte Death

Sonidegib, a Novel Inhibitor of Suicidal Erythrocyte Death

Background/Aims: The Hedgehog pathway disrupting drug sonidegib is used in the treatment of basal cell carcinoma. Side effects of sonidegib include anemia, which could result either from impaired erythropoiesis or from loss of erythrocytes e.g. due to suicidal erythrocyte death or eryptosis, which i...

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Bibliographic Details
Main Authors: Abdulla Al Mamun Bhuyan, Itishri Sahu, Hang Cao, Florian Lang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Phosphatidylserine
Eryptosis
Energy depletion
Oxidative stress
Hyperosmotic shock
Ionomycin
Calcium
Online Access:https://www.karger.com/Article/FullText/490820

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