Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD)
The aim of this study was to investigate the effects of long-term weight gain from the age of 20 on incidence of hyper-low-density-lipoprotein (LDL) cholesterolemia in the general population of Japanese people. Methods: We conducted a population-based retrospective cohort study using annual health c...
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MDPI AG
2021-07-01
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| author | Shota Okutsu Yoshifumi Kato Shunsuke Funakoshi Toshiki Maeda Chikara Yoshimura Miki Kawazoe Atsushi Satoh Soichiro Yokota Kazuhiro Tada Koji Takahashi Kenji Ito Tetsuhiko Yasuno Hideyuki Fujii Shigeaki Mukoubara Hitoshi Nakashima Daiji Kawanami Kosuke Masutani Hisatomi Arima Shigeki Nabeshima |
| author_facet | Shota Okutsu Yoshifumi Kato Shunsuke Funakoshi Toshiki Maeda Chikara Yoshimura Miki Kawazoe Atsushi Satoh Soichiro Yokota Kazuhiro Tada Koji Takahashi Kenji Ito Tetsuhiko Yasuno Hideyuki Fujii Shigeaki Mukoubara Hitoshi Nakashima Daiji Kawanami Kosuke Masutani Hisatomi Arima Shigeki Nabeshima |
| author_sort | Shota Okutsu |
| collection | DOAJ |
| description | The aim of this study was to investigate the effects of long-term weight gain from the age of 20 on incidence of hyper-low-density-lipoprotein (LDL) cholesterolemia in the general population of Japanese people. Methods: We conducted a population-based retrospective cohort study using annual health checkup data for residents of Iki City, Nagasaki Prefecture, Japan. A total of 3179 adult (≥30 years old) men and women without hyper-LDL cholesterolemia at baseline, who underwent two or more health checkups were included in the analysis. Information on weight gain (≥10 kg) after 20 years of age was obtained using questionnaire. The outcome of this study was development of hyper-LDL cholesterolemia defined as LDL-cholesterol level ≥3.62 mmol/L and/or initiation of lipid-lowering medications. Results: During a mean follow-up period of 4.53 years, 665 of the 3179 participants developed hyper-LDL cholesterolemia (46.5/1000 person-years). The incidence of hyper-LDL cholesterolemia was higher in participants with a weight gain of ≥10 kg (55.3/1000 person-years) than among those with a weight gain of <10 kg (41.8/1000 person-years). This association remained statistically significant even after adjustment for age, sex, smoking, daily drinking, exercise, obesity, hypertension, and diabetes (multivariable hazard ratio 1.31, 95% confidence interval 1.08–1.58, <i>p</i> = 0.006). Conclusion: A weight gain of ≥10 after 20 years of age affected the development of hyper-LDL cholesterol regardless of age, sex, and obesity in a general population of Japanese. |
| first_indexed | 2024-03-10T09:35:00Z |
| format | Article |
| id | doaj.art-1049524d2ecf45b0a9aeb53f5a27d488 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:35:00Z |
| publishDate | 2021-07-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-1049524d2ecf45b0a9aeb53f5a27d4882023-11-22T04:06:41ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011014309810.3390/jcm10143098Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD)Shota Okutsu0Yoshifumi Kato1Shunsuke Funakoshi2Toshiki Maeda3Chikara Yoshimura4Miki Kawazoe5Atsushi Satoh6Soichiro Yokota7Kazuhiro Tada8Koji Takahashi9Kenji Ito10Tetsuhiko Yasuno11Hideyuki Fujii12Shigeaki Mukoubara13Hitoshi Nakashima14Daiji Kawanami15Kosuke Masutani16Hisatomi Arima17Shigeki Nabeshima18General Medicine, Fukuoka University Hospital, Fukuoka 814-0180, JapanGeneral Medicine, Fukuoka University Hospital, Fukuoka 814-0180, JapanDepartment of Preventive Medicine and Public Health, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Preventive Medicine and Public Health, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Preventive Medicine and Public Health, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Preventive Medicine and Public Health, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Preventive Medicine and Public Health, Fukuoka University, Fukuoka 814-0180, JapanDivision of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University, Fukuoka 814-0180, JapanDivision of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University, Fukuoka 814-0180, JapanDivision of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University, Fukuoka 814-0180, JapanDivision of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University, Fukuoka 814-0180, JapanDivision of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanNagasaki Prefecture Iki Hospital, Nagasaki 811-5132, JapanDivision of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Endocrinology and Diabetes Mellitus, Fukuoka University School of Medicine, Fukuoka 814-0180, JapanDivision of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University, Fukuoka 814-0180, JapanDepartment of Preventive Medicine and Public Health, Fukuoka University, Fukuoka 814-0180, JapanGeneral Medicine, Fukuoka University Hospital, Fukuoka 814-0180, JapanThe aim of this study was to investigate the effects of long-term weight gain from the age of 20 on incidence of hyper-low-density-lipoprotein (LDL) cholesterolemia in the general population of Japanese people. Methods: We conducted a population-based retrospective cohort study using annual health checkup data for residents of Iki City, Nagasaki Prefecture, Japan. A total of 3179 adult (≥30 years old) men and women without hyper-LDL cholesterolemia at baseline, who underwent two or more health checkups were included in the analysis. Information on weight gain (≥10 kg) after 20 years of age was obtained using questionnaire. The outcome of this study was development of hyper-LDL cholesterolemia defined as LDL-cholesterol level ≥3.62 mmol/L and/or initiation of lipid-lowering medications. Results: During a mean follow-up period of 4.53 years, 665 of the 3179 participants developed hyper-LDL cholesterolemia (46.5/1000 person-years). The incidence of hyper-LDL cholesterolemia was higher in participants with a weight gain of ≥10 kg (55.3/1000 person-years) than among those with a weight gain of <10 kg (41.8/1000 person-years). This association remained statistically significant even after adjustment for age, sex, smoking, daily drinking, exercise, obesity, hypertension, and diabetes (multivariable hazard ratio 1.31, 95% confidence interval 1.08–1.58, <i>p</i> = 0.006). Conclusion: A weight gain of ≥10 after 20 years of age affected the development of hyper-LDL cholesterol regardless of age, sex, and obesity in a general population of Japanese.https://www.mdpi.com/2077-0383/10/14/3098weight gainLDL cholesterolhyper-LDL cholesterolemialongitudinal studygeneral population |
| spellingShingle | Shota Okutsu Yoshifumi Kato Shunsuke Funakoshi Toshiki Maeda Chikara Yoshimura Miki Kawazoe Atsushi Satoh Soichiro Yokota Kazuhiro Tada Koji Takahashi Kenji Ito Tetsuhiko Yasuno Hideyuki Fujii Shigeaki Mukoubara Hitoshi Nakashima Daiji Kawanami Kosuke Masutani Hisatomi Arima Shigeki Nabeshima Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD) Journal of Clinical Medicine weight gain LDL cholesterol hyper-LDL cholesterolemia longitudinal study general population |
| title | Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD) |
| title_full | Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD) |
| title_fullStr | Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD) |
| title_full_unstemmed | Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD) |
| title_short | Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD) |
| title_sort | effects of weight gain after 20 years of age and incidence of hyper low density lipoprotein cholesterolemia the iki epidemiological study of atherosclerosis and chronic kidney disease issa ckd |
| topic | weight gain LDL cholesterol hyper-LDL cholesterolemia longitudinal study general population |
| url | https://www.mdpi.com/2077-0383/10/14/3098 |
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