Burdock fructooligosaccharide ameliorates the hypercholesterolemia and vascular inflammation in mice by regulating cholesterol homeostasis and anti-inflammatory properties
Burdock fructooligosaccharide (BFO) is a type of linear inulin extracted from burdock root. In this study, we studied the effect of BFO in hypercholesterolemic mice model and found that BFO could decrease the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and oxidized LDL (ox-LD...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623002785 |
| _version_ | 1797749150617436160 |
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| author | Ying Meng Qunfei Ma Xuan Xu Liting Feng Qiang Chen Yiru Chen Zhang Li Chunyan Liu Kaoshan Chen |
| author_facet | Ying Meng Qunfei Ma Xuan Xu Liting Feng Qiang Chen Yiru Chen Zhang Li Chunyan Liu Kaoshan Chen |
| author_sort | Ying Meng |
| collection | DOAJ |
| description | Burdock fructooligosaccharide (BFO) is a type of linear inulin extracted from burdock root. In this study, we studied the effect of BFO in hypercholesterolemic mice model and found that BFO could decrease the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and oxidized LDL (ox-LDL). BFO also reduce the hepatocyte damage, improve the antioxidant enzymes activity and regulate genes related to the cholesterol homeostasis in liver. Besides, we found that BFO protected the blood vessels by significantly balancing inflammatory cytokines and alleviating the up-regulation of TLR4/MyD88/NF-κB pathway in aorta. Furthermore, we established a foam cells model induced by ox-LDL in vitro and found that 500 and 1000 μg/mL BFO could effectively inhibit cell proliferation and reduce the production of intracellular lipids and inflammatory cytokines. Therefore, BFO can reduce the risk of hypercholesterolemia by maintaining cholesterol homeostasis, reducing vascular inflammation and alleviating macrophage foaming to prevent its further development into cardiovascular diseases. |
| first_indexed | 2024-03-12T16:15:07Z |
| format | Article |
| id | doaj.art-1049acb5a8bd4637b3bfa0c0fc64c4a6 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-12T16:15:07Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-1049acb5a8bd4637b3bfa0c0fc64c4a62023-08-09T04:32:34ZengElsevierJournal of Functional Foods1756-46462023-08-01107105678Burdock fructooligosaccharide ameliorates the hypercholesterolemia and vascular inflammation in mice by regulating cholesterol homeostasis and anti-inflammatory propertiesYing Meng0Qunfei Ma1Xuan Xu2Liting Feng3Qiang Chen4Yiru Chen5Zhang Li6Chunyan Liu7Kaoshan Chen8School of Life Science, Shandong University, No. 72 Binhai Road, Qingdao 266237, ChinaSchool of Life Science, Shandong University, No. 72 Binhai Road, Qingdao 266237, China; Department of Physiology, College of Basic Medical Sciences, Naval Medical University, Shanghai 200433, China; Corresponding authors at: School of Life Science, Shandong University, No. 72 Binhai Road, Qingdao 266237, China.School of Life Science, Shandong University, No. 72 Binhai Road, Qingdao 266237, ChinaSchool of Life Science, Shandong University, No. 72 Binhai Road, Qingdao 266237, ChinaBurdock Biotechnology (Dezhou) Co., Ltd, Dezhou, 253400, ChinaBurdock Biotechnology (Dezhou) Co., Ltd, Dezhou, 253400, ChinaSchool of Life Science, Shandong University, No. 72 Binhai Road, Qingdao 266237, China; Drug Research & Development Center, School of Pharmacy, Wannan Medical College, Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Provincial Engineering Laboratory for Screening and Re-Evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Wuhu 241002, ChinaDrug Research & Development Center, School of Pharmacy, Wannan Medical College, Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Provincial Engineering Laboratory for Screening and Re-Evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Wuhu 241002, China; Corresponding authors at: School of Life Science, Shandong University, No. 72 Binhai Road, Qingdao 266237, China.School of Life Science, Shandong University, No. 72 Binhai Road, Qingdao 266237, China; Drug Research & Development Center, School of Pharmacy, Wannan Medical College, Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Provincial Engineering Laboratory for Screening and Re-Evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Wuhu 241002, China; Corresponding authors at: School of Life Science, Shandong University, No. 72 Binhai Road, Qingdao 266237, China.Burdock fructooligosaccharide (BFO) is a type of linear inulin extracted from burdock root. In this study, we studied the effect of BFO in hypercholesterolemic mice model and found that BFO could decrease the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and oxidized LDL (ox-LDL). BFO also reduce the hepatocyte damage, improve the antioxidant enzymes activity and regulate genes related to the cholesterol homeostasis in liver. Besides, we found that BFO protected the blood vessels by significantly balancing inflammatory cytokines and alleviating the up-regulation of TLR4/MyD88/NF-κB pathway in aorta. Furthermore, we established a foam cells model induced by ox-LDL in vitro and found that 500 and 1000 μg/mL BFO could effectively inhibit cell proliferation and reduce the production of intracellular lipids and inflammatory cytokines. Therefore, BFO can reduce the risk of hypercholesterolemia by maintaining cholesterol homeostasis, reducing vascular inflammation and alleviating macrophage foaming to prevent its further development into cardiovascular diseases.http://www.sciencedirect.com/science/article/pii/S1756464623002785Burdock fructooligosaccharideHypercholesterolemiaCholesterol metabolismVascular inflammationFoam cell |
| spellingShingle | Ying Meng Qunfei Ma Xuan Xu Liting Feng Qiang Chen Yiru Chen Zhang Li Chunyan Liu Kaoshan Chen Burdock fructooligosaccharide ameliorates the hypercholesterolemia and vascular inflammation in mice by regulating cholesterol homeostasis and anti-inflammatory properties Journal of Functional Foods Burdock fructooligosaccharide Hypercholesterolemia Cholesterol metabolism Vascular inflammation Foam cell |
| title | Burdock fructooligosaccharide ameliorates the hypercholesterolemia and vascular inflammation in mice by regulating cholesterol homeostasis and anti-inflammatory properties |
| title_full | Burdock fructooligosaccharide ameliorates the hypercholesterolemia and vascular inflammation in mice by regulating cholesterol homeostasis and anti-inflammatory properties |
| title_fullStr | Burdock fructooligosaccharide ameliorates the hypercholesterolemia and vascular inflammation in mice by regulating cholesterol homeostasis and anti-inflammatory properties |
| title_full_unstemmed | Burdock fructooligosaccharide ameliorates the hypercholesterolemia and vascular inflammation in mice by regulating cholesterol homeostasis and anti-inflammatory properties |
| title_short | Burdock fructooligosaccharide ameliorates the hypercholesterolemia and vascular inflammation in mice by regulating cholesterol homeostasis and anti-inflammatory properties |
| title_sort | burdock fructooligosaccharide ameliorates the hypercholesterolemia and vascular inflammation in mice by regulating cholesterol homeostasis and anti inflammatory properties |
| topic | Burdock fructooligosaccharide Hypercholesterolemia Cholesterol metabolism Vascular inflammation Foam cell |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623002785 |
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