2-((5-(3-(2-Fluorophenyl)acryloyl)-4-methylthiazol-2-yl)amino)isoindoline-1,3-dione

2-((5-(3-(2-Fluorophenyl)acryloyl)-4-methylthiazol-2-yl)amino)isoindoline-1,3-dione

In this work, the title compound was synthesized via the Claisen–Schmidt condensation of a 2-((5-acetyl-4-methylthiazol-2-yl)amino)isoindoline-1,3-dione with 2-fluorobenzaldehyde. The structure of the synthesized compound (yield 62%) was confirmed by <sup>1</sup>H, <sup>13</sup&...

Full description

Bibliographic Details
Main Authors: Olha-Maria Fedusevych, Andrii Lozynskyi, Marta Sulyma, Roman Lesyk
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molbank
Subjects:
thiazole
Claisen–Schmidt condensation
anticancer activity
pharmacokinetics prediction
Online Access:https://www.mdpi.com/1422-8599/2024/1/M1785
Description
Summary:In this work, the title compound was synthesized via the Claisen–Schmidt condensation of a 2-((5-acetyl-4-methylthiazol-2-yl)amino)isoindoline-1,3-dione with 2-fluorobenzaldehyde. The structure of the synthesized compound (yield 62%) was confirmed by <sup>1</sup>H, <sup>13</sup>C NMR, and LC–MS spectra. According to US NCI protocols, the compound displayed a high level of antimitotic activity against tested human tumor cells, with mean GI<sub>50</sub>/TGI values of 15.72/50.68 μM. The drug-like properties of the synthesized compound were evaluated using SwissAdme, revealing satisfactory drug-like parameters, and it presents interest for the design of new synthetic agents with biological activity.
ISSN:1422-8599

Similar Items