Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target
Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understand...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/6/891 |
| _version_ | 1797565407106695168 |
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| author | Yen-Chung Lai Chiao-Hsuan Chao Trai-Ming Yeh |
| author_facet | Yen-Chung Lai Chiao-Hsuan Chao Trai-Ming Yeh |
| author_sort | Yen-Chung Lai |
| collection | DOAJ |
| description | Dengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed. |
| first_indexed | 2024-03-10T19:11:45Z |
| format | Article |
| id | doaj.art-104afbf07f4c4a50881093af82cd57c1 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T19:11:45Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-104afbf07f4c4a50881093af82cd57c12023-11-20T03:40:54ZengMDPI AGMicroorganisms2076-26072020-06-018689110.3390/microorganisms8060891Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic TargetYen-Chung Lai0Chiao-Hsuan Chao1Trai-Ming Yeh2Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, TaiwanInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, TaiwanDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 70101, TaiwanDengue virus (DENV) infection is the most prevalent mosquito-borne viral infection and can lead to severe dengue hemorrhagic fever (DHF) and even life-threatening dengue shock syndrome (DSS). Although the cytokine storm has been revealed as a critical factor in dengue disease, the limited understanding of dengue immunopathogenesis hinders the development of effective treatments. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that mediates diverse immune responses, and the serum level of MIF positively correlates with disease severity in patients with dengue. MIF is involved in DENV replication and many pathological changes, such as vascular leakage, during DENV infection. In this paper, the pathogenic roles of MIF and the regulation of MIF secretion during DENV infection are reviewed. Furthermore, whether MIF is a potential therapeutic target against DENV infection is also discussed.https://www.mdpi.com/2076-2607/8/6/891Dengue virusdengue pathogenesismacrophage migration inhibitory factorautophagy |
| spellingShingle | Yen-Chung Lai Chiao-Hsuan Chao Trai-Ming Yeh Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target Microorganisms Dengue virus dengue pathogenesis macrophage migration inhibitory factor autophagy |
| title | Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target |
| title_full | Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target |
| title_fullStr | Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target |
| title_full_unstemmed | Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target |
| title_short | Roles of Macrophage Migration Inhibitory Factor in Dengue Pathogenesis: From Pathogenic Factor to Therapeutic Target |
| title_sort | roles of macrophage migration inhibitory factor in dengue pathogenesis from pathogenic factor to therapeutic target |
| topic | Dengue virus dengue pathogenesis macrophage migration inhibitory factor autophagy |
| url | https://www.mdpi.com/2076-2607/8/6/891 |
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