The association between gout flares and monosodium urate burden assessed using musculoskeletal ultrasound in patients with gout
Background: Ultrasound (US) has a high sensitivity in detecting monosodium urate (MSU) deposition in gout patients. However, the value of US in predicting gout flares has been reported only in a few monocentric studies. Objective: To investigate the association between gout flares in the previous ye...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-03-01
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| Series: | Therapeutic Advances in Musculoskeletal Disease |
| Online Access: | https://doi.org/10.1177/1759720X241240837 |
| _version_ | 1827572237224378368 |
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| author | Shaoling Yang Xiaojing Lin Yining Gao Nan Liang Yali Han Hang Sun Shen Qu Haibing Chen |
| author_facet | Shaoling Yang Xiaojing Lin Yining Gao Nan Liang Yali Han Hang Sun Shen Qu Haibing Chen |
| author_sort | Shaoling Yang |
| collection | DOAJ |
| description | Background: Ultrasound (US) has a high sensitivity in detecting monosodium urate (MSU) deposition in gout patients. However, the value of US in predicting gout flares has been reported only in a few monocentric studies. Objective: To investigate the association between gout flares in the previous year and US-detected MSU burden using two different US scores. Design: A retrospective study. Methods: Patients with gout were consecutively recruited to undergo musculoskeletal US examinations of their knees, ankles, and feet. The score derived from Outcome Measure in Rheumatology (hereinafter referred to as MSU score) and musculoskeletal US features-based (hereinafter referred to as MSKF score) were used to quantify the MSU burden of gout. Odds ratios for frequent gout flares were calculated. Results: We enrolled 1894 patients with gout (mean age: 45 years; gout duration: 5 years; males: 96.1%), experiencing a median of three flares over the past year. Of these, 428 (22.6%) patients reported frequent (⩾7) gout flares. The MSU and MSKF median scores were 6 and 9, respectively. For each five-point increase in MSU and MSKF score, the odds ratio of frequent gout flares increased 1.13-fold and 1.24-fold, respectively. The area under the curve (AUC) for the MSU and MSKF score was 0.635 [95% confidence interval (CI): 0.604–0.665] and 0.688 (95% CI: 0.659–0.718), respectively, (AUC difference 0.054, p value for AUC difference < 0.001). Conclusion: The MSU and MSKF scores were significantly associated with the number of gout flares in the previous year. The MSKF score outperformed the MSU score in terms of frequent gout flare discrimination. |
| first_indexed | 2024-04-24T16:26:28Z |
| format | Article |
| id | doaj.art-104d413a6a894b34998940cb67790ea3 |
| institution | Directory Open Access Journal |
| issn | 1759-7218 |
| language | English |
| last_indexed | 2024-04-24T16:26:28Z |
| publishDate | 2024-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Musculoskeletal Disease |
| spelling | doaj.art-104d413a6a894b34998940cb67790ea32024-03-31T01:03:43ZengSAGE PublishingTherapeutic Advances in Musculoskeletal Disease1759-72182024-03-011610.1177/1759720X241240837The association between gout flares and monosodium urate burden assessed using musculoskeletal ultrasound in patients with goutShaoling YangXiaojing LinYining GaoNan LiangYali HanHang SunShen QuHaibing ChenBackground: Ultrasound (US) has a high sensitivity in detecting monosodium urate (MSU) deposition in gout patients. However, the value of US in predicting gout flares has been reported only in a few monocentric studies. Objective: To investigate the association between gout flares in the previous year and US-detected MSU burden using two different US scores. Design: A retrospective study. Methods: Patients with gout were consecutively recruited to undergo musculoskeletal US examinations of their knees, ankles, and feet. The score derived from Outcome Measure in Rheumatology (hereinafter referred to as MSU score) and musculoskeletal US features-based (hereinafter referred to as MSKF score) were used to quantify the MSU burden of gout. Odds ratios for frequent gout flares were calculated. Results: We enrolled 1894 patients with gout (mean age: 45 years; gout duration: 5 years; males: 96.1%), experiencing a median of three flares over the past year. Of these, 428 (22.6%) patients reported frequent (⩾7) gout flares. The MSU and MSKF median scores were 6 and 9, respectively. For each five-point increase in MSU and MSKF score, the odds ratio of frequent gout flares increased 1.13-fold and 1.24-fold, respectively. The area under the curve (AUC) for the MSU and MSKF score was 0.635 [95% confidence interval (CI): 0.604–0.665] and 0.688 (95% CI: 0.659–0.718), respectively, (AUC difference 0.054, p value for AUC difference < 0.001). Conclusion: The MSU and MSKF scores were significantly associated with the number of gout flares in the previous year. The MSKF score outperformed the MSU score in terms of frequent gout flare discrimination.https://doi.org/10.1177/1759720X241240837 |
| spellingShingle | Shaoling Yang Xiaojing Lin Yining Gao Nan Liang Yali Han Hang Sun Shen Qu Haibing Chen The association between gout flares and monosodium urate burden assessed using musculoskeletal ultrasound in patients with gout Therapeutic Advances in Musculoskeletal Disease |
| title | The association between gout flares and monosodium urate burden assessed using musculoskeletal ultrasound in patients with gout |
| title_full | The association between gout flares and monosodium urate burden assessed using musculoskeletal ultrasound in patients with gout |
| title_fullStr | The association between gout flares and monosodium urate burden assessed using musculoskeletal ultrasound in patients with gout |
| title_full_unstemmed | The association between gout flares and monosodium urate burden assessed using musculoskeletal ultrasound in patients with gout |
| title_short | The association between gout flares and monosodium urate burden assessed using musculoskeletal ultrasound in patients with gout |
| title_sort | association between gout flares and monosodium urate burden assessed using musculoskeletal ultrasound in patients with gout |
| url | https://doi.org/10.1177/1759720X241240837 |
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