Correlation between Metabolite of Prostaglandin E2 and the incidence of colorectal adenomas
Colorectal cancer is a common malignancy, and the incidence and mortality rates continue to rise. An important factor in the emergence of inflammation-induced colorectal carcinogenesis is elevated cyclooxygenase-2. Prostaglandin E2 (PGE2) over-production is frequently equated with cyclooxygenase-2 g...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1068469/full |
| _version_ | 1797894236545220608 |
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| author | Jia Jiang Anjie Li Xiaolian Lai Hanqun Zhang Chonghong Wang Huimin Wang Libo Li Yuncong Liu Lu Xie Can Yang Cui Zhang Shuoyan Lu Yong Li |
| author_facet | Jia Jiang Anjie Li Xiaolian Lai Hanqun Zhang Chonghong Wang Huimin Wang Libo Li Yuncong Liu Lu Xie Can Yang Cui Zhang Shuoyan Lu Yong Li |
| author_sort | Jia Jiang |
| collection | DOAJ |
| description | Colorectal cancer is a common malignancy, and the incidence and mortality rates continue to rise. An important factor in the emergence of inflammation-induced colorectal carcinogenesis is elevated cyclooxygenase-2. Prostaglandin E2 (PGE2) over-production is frequently equated with cyclooxygenase-2 gene over-expression. PGE2 can be assessed by measuring the level of prostaglandin’s main metabolite, PGE-M, in urine. Colorectal adenoma is a precancerous lesion that can lead to colorectal cancer. We conducted research to evaluate the association between urinary levels of the PGE-M and the risk of colorectal adenomas. In a western Chinese population, we identified 152 cases of adenoma and 152 controls patients without polyps. Adenoma cases were categorized into control, low-risk and high-risk groups. There was no significant change in PGE-M levels, between the control group and the low-risk adenoma group. In the high-risk group, the PGE-M levels were 23% higher than the control group. When compared to people with the lowest urine PGE-M levels (first quartile), people with greater urinary PGE-M levels had a higher chance of developing high-risk colorectal adenomas, with an adjusted odds ratio (95% CI) of 1.65 (0.76-3.57) in the fourth quartile group, (p= 0.013). We conclude urinary PGE-M is associated with the risk of developing high-risk adenomas. Urinary PGE-M level may be used as a non-invasive indicator for estimating cancer risk. |
| first_indexed | 2024-04-10T07:05:47Z |
| format | Article |
| id | doaj.art-104d918ac47f4adb85eac4258168887a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T07:05:47Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-104d918ac47f4adb85eac4258168887a2023-02-27T07:28:10ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-02-011310.3389/fonc.2023.10684691068469Correlation between Metabolite of Prostaglandin E2 and the incidence of colorectal adenomasJia Jiang0Anjie Li1Xiaolian Lai2Hanqun Zhang3Chonghong Wang4Huimin Wang5Libo Li6Yuncong Liu7Lu Xie8Can Yang9Cui Zhang10Shuoyan Lu11Yong Li12Guizhou University of Traditional Chinese Medicine, Guiyang, ChinaDepartment of Medicine-Cardiovascular, Guizhou Provincial People’s Hospital, Guiyang, ChinaDepartment of Digestive, People's Hospital of Songtao Miao Autonomous County, Tongren, ChinaDepartment of Oncology, Guizhou Provincial People’s Hospital, Guiyang, ChinaDepartment of Digestive, People's Hospital of Songtao Miao Autonomous County, Tongren, ChinaDepartment of Digestive, People's Hospital of Songtao Miao Autonomous County, Tongren, ChinaDepartment of Oncology, Guizhou Provincial People’s Hospital, Guiyang, ChinaDepartment of Oncology, Guizhou Provincial People’s Hospital, Guiyang, ChinaGuizhou University of Traditional Chinese Medicine, Guiyang, ChinaGuizhou University of Traditional Chinese Medicine, Guiyang, ChinaZunyi Medical University, Zunyi, ChinaDepartment of Digestive, People's Hospital of Songtao Miao Autonomous County, Tongren, ChinaDepartment of Oncology, Guizhou Provincial People’s Hospital, Guiyang, ChinaColorectal cancer is a common malignancy, and the incidence and mortality rates continue to rise. An important factor in the emergence of inflammation-induced colorectal carcinogenesis is elevated cyclooxygenase-2. Prostaglandin E2 (PGE2) over-production is frequently equated with cyclooxygenase-2 gene over-expression. PGE2 can be assessed by measuring the level of prostaglandin’s main metabolite, PGE-M, in urine. Colorectal adenoma is a precancerous lesion that can lead to colorectal cancer. We conducted research to evaluate the association between urinary levels of the PGE-M and the risk of colorectal adenomas. In a western Chinese population, we identified 152 cases of adenoma and 152 controls patients without polyps. Adenoma cases were categorized into control, low-risk and high-risk groups. There was no significant change in PGE-M levels, between the control group and the low-risk adenoma group. In the high-risk group, the PGE-M levels were 23% higher than the control group. When compared to people with the lowest urine PGE-M levels (first quartile), people with greater urinary PGE-M levels had a higher chance of developing high-risk colorectal adenomas, with an adjusted odds ratio (95% CI) of 1.65 (0.76-3.57) in the fourth quartile group, (p= 0.013). We conclude urinary PGE-M is associated with the risk of developing high-risk adenomas. Urinary PGE-M level may be used as a non-invasive indicator for estimating cancer risk.https://www.frontiersin.org/articles/10.3389/fonc.2023.1068469/fullcolorectal adenomaprostaglandin E2PGE-MColorectal cancercancer riskbio-markers |
| spellingShingle | Jia Jiang Anjie Li Xiaolian Lai Hanqun Zhang Chonghong Wang Huimin Wang Libo Li Yuncong Liu Lu Xie Can Yang Cui Zhang Shuoyan Lu Yong Li Correlation between Metabolite of Prostaglandin E2 and the incidence of colorectal adenomas Frontiers in Oncology colorectal adenoma prostaglandin E2 PGE-M Colorectal cancer cancer risk bio-markers |
| title | Correlation between Metabolite of Prostaglandin E2 and the incidence of colorectal adenomas |
| title_full | Correlation between Metabolite of Prostaglandin E2 and the incidence of colorectal adenomas |
| title_fullStr | Correlation between Metabolite of Prostaglandin E2 and the incidence of colorectal adenomas |
| title_full_unstemmed | Correlation between Metabolite of Prostaglandin E2 and the incidence of colorectal adenomas |
| title_short | Correlation between Metabolite of Prostaglandin E2 and the incidence of colorectal adenomas |
| title_sort | correlation between metabolite of prostaglandin e2 and the incidence of colorectal adenomas |
| topic | colorectal adenoma prostaglandin E2 PGE-M Colorectal cancer cancer risk bio-markers |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1068469/full |
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