Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice
In the laboratory, long-term social recognition memory (SRM) in mice is highly susceptible to proactive and retroactive interference. Here, we investigate the ability of novel designed dopamine (DA) re-uptake inhibitors (rac-CE-123 and S-CE-123) to block retroactive and proactive interference, respe...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00063/full |
| _version_ | 1811328183795974144 |
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| author | Judith Camats-Perna Predrag Kalaba Karl Ebner Simone B. Sartori Harish Vuyyuru Nilima Y. Aher Vladimir Dragačević Nicolas Singewald Mario Engelmann Mario Engelmann Gert Lubec |
| author_facet | Judith Camats-Perna Predrag Kalaba Karl Ebner Simone B. Sartori Harish Vuyyuru Nilima Y. Aher Vladimir Dragačević Nicolas Singewald Mario Engelmann Mario Engelmann Gert Lubec |
| author_sort | Judith Camats-Perna |
| collection | DOAJ |
| description | In the laboratory, long-term social recognition memory (SRM) in mice is highly susceptible to proactive and retroactive interference. Here, we investigate the ability of novel designed dopamine (DA) re-uptake inhibitors (rac-CE-123 and S-CE-123) to block retroactive and proactive interference, respectively. Our data show that administration of rac-CE-123 30 min before learning blocks retroactive interference that has been experimentally induced at 3 h, but not at 6 h, post-learning. In contrast, S-CE-123 treatment 30 min before learning blocked the induction of retroactive interference at 6 h, but not 3 h, post-learning. Administration of S-CE-123 failed to interfere with proactive interference at both 3 h and 6 h. Analysis of additional behavioral parameters collected during the memory task implies that the effects of the new DA re-uptake inhibitors on retroactive and proactive interference cannot easily be explained by non-specific effects on the animals’ general social behavior. Furthermore, we assessed the mechanisms of action of drugs using intracerebral in vivo-microdialysis technique. The results revealed that administration of rac-CE-123 and S-CE-123 dose-dependently increased DA release within the nucleus accumbens of freely behaving mice. Thus, the data from the present study suggests that the DA re-uptake inhibitors tested protect the consolidation of long-term social memory against interference for defined durations after learning. In addition, the data implies that DA signaling in distinct brain areas including the nucleus accumbens is involved in the consolidation of SRM in laboratory mice. |
| first_indexed | 2024-04-13T15:21:49Z |
| format | Article |
| id | doaj.art-104ea673a7bd496b93a399f44e70ca3f |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-13T15:21:49Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-104ea673a7bd496b93a399f44e70ca3f2022-12-22T02:41:39ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-04-011310.3389/fnbeh.2019.00063421391Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in MiceJudith Camats-Perna0Predrag Kalaba1Karl Ebner2Simone B. Sartori3Harish Vuyyuru4Nilima Y. Aher5Vladimir Dragačević6Nicolas Singewald7Mario Engelmann8Mario Engelmann9Gert Lubec10AG Neuroendokrinologie und Verhalten, Institut für Biochemie und Zellbiologie, Otto-von-Guericke-Universität Magdeburg, Magdeburg, GermanyDepartment of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna, AustriaCenter for Molecular Biosciences Innsbruck (CMBI), Department of Pharmacology and Toxicology, Institute of Pharmacy, Leopold Franzens University Innsbruck, Innsbruck, AustriaCenter for Molecular Biosciences Innsbruck (CMBI), Department of Pharmacology and Toxicology, Institute of Pharmacy, Leopold Franzens University Innsbruck, Innsbruck, AustriaDepartment of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna, AustriaDepartment of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna, AustriaDepartment of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna, AustriaCenter for Molecular Biosciences Innsbruck (CMBI), Department of Pharmacology and Toxicology, Institute of Pharmacy, Leopold Franzens University Innsbruck, Innsbruck, AustriaAG Neuroendokrinologie und Verhalten, Institut für Biochemie und Zellbiologie, Otto-von-Guericke-Universität Magdeburg, Magdeburg, GermanyCenter for Behavioral Brain Sciences, Magdeburg, GermanyDepartment of Neuroproteomics, Paracelsus Medical University, Salzburg, AustriaIn the laboratory, long-term social recognition memory (SRM) in mice is highly susceptible to proactive and retroactive interference. Here, we investigate the ability of novel designed dopamine (DA) re-uptake inhibitors (rac-CE-123 and S-CE-123) to block retroactive and proactive interference, respectively. Our data show that administration of rac-CE-123 30 min before learning blocks retroactive interference that has been experimentally induced at 3 h, but not at 6 h, post-learning. In contrast, S-CE-123 treatment 30 min before learning blocked the induction of retroactive interference at 6 h, but not 3 h, post-learning. Administration of S-CE-123 failed to interfere with proactive interference at both 3 h and 6 h. Analysis of additional behavioral parameters collected during the memory task implies that the effects of the new DA re-uptake inhibitors on retroactive and proactive interference cannot easily be explained by non-specific effects on the animals’ general social behavior. Furthermore, we assessed the mechanisms of action of drugs using intracerebral in vivo-microdialysis technique. The results revealed that administration of rac-CE-123 and S-CE-123 dose-dependently increased DA release within the nucleus accumbens of freely behaving mice. Thus, the data from the present study suggests that the DA re-uptake inhibitors tested protect the consolidation of long-term social memory against interference for defined durations after learning. In addition, the data implies that DA signaling in distinct brain areas including the nucleus accumbens is involved in the consolidation of SRM in laboratory mice.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00063/fullcognitive enhancementsocial recognition memoryretroactive interferenceaggression social interactiondopamine transport inhibitorlong-term memory |
| spellingShingle | Judith Camats-Perna Predrag Kalaba Karl Ebner Simone B. Sartori Harish Vuyyuru Nilima Y. Aher Vladimir Dragačević Nicolas Singewald Mario Engelmann Mario Engelmann Gert Lubec Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice Frontiers in Behavioral Neuroscience cognitive enhancement social recognition memory retroactive interference aggression social interaction dopamine transport inhibitor long-term memory |
| title | Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice |
| title_full | Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice |
| title_fullStr | Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice |
| title_full_unstemmed | Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice |
| title_short | Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice |
| title_sort | differential effects of novel dopamine reuptake inhibitors on interference with long term social memory in mice |
| topic | cognitive enhancement social recognition memory retroactive interference aggression social interaction dopamine transport inhibitor long-term memory |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00063/full |
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