Significant association of rheumatoid arthritis-related inflammatory markers with non-surgical periodontal therapy
Background/Purpose: Chronic periodontitis (CP) and rheumatoid arthritis (RA) are the most common chronic inflammatory diseases and their immunopathogenesis is similar. The aim of this study was to evaluate the effect of non-surgical periodontal treatment on the serum levels of RA-related inflammator...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-11-01
|
| Series: | Journal of the Formosan Medical Association |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664617307623 |
| _version_ | 1818059644297281536 |
|---|---|
| author | Ning-Ya Yang Chen-Ying Wang I-Tsu Chyuan King-Jean Wu Yu-Kang Tu Ching-Wen Chang Ping-Ning Hsu Mark Yen-Ping Kuo Yi-Wen Chen |
| author_facet | Ning-Ya Yang Chen-Ying Wang I-Tsu Chyuan King-Jean Wu Yu-Kang Tu Ching-Wen Chang Ping-Ning Hsu Mark Yen-Ping Kuo Yi-Wen Chen |
| author_sort | Ning-Ya Yang |
| collection | DOAJ |
| description | Background/Purpose: Chronic periodontitis (CP) and rheumatoid arthritis (RA) are the most common chronic inflammatory diseases and their immunopathogenesis is similar. The aim of this study was to evaluate the effect of non-surgical periodontal treatment on the serum levels of RA-related inflammatory markers in patients with chronic periodontitis. Methods: Thirty-one Taiwanese adults with CP were included. Demographics and periodontal parameters, including probing depth, clinical attachment level, and number of remaining teeth in the oral cavity, were recorded. All subjects received non-surgical periodontal treatment such as scaling and subgingival root planing. Serum samples were collected before and after the treatment. Serum levels of anti-citrullinated protein antibodies (ACPA), rheumatoid factor, tumor necrosis factor-α (TNF-α), C-reactive protein, interleukin-1β (IL-1β), and Interleukin-6 (IL-6) were measured using an enzyme-linked immunosorbent assay. Results: Non-surgical periodontal treatment significantly reduced the serum ACPA (p = 0.015) and TNF-α levels (p = 0.026) in CP patients, particularly in patients with generalized CP. Furthermore, there was a significant and positive correlation between the number of extracted teeth and the reduction in the serum ACPA (p = 0.05) and IL-1β levels (p = 0.029) after non-surgical periodontal treatment. Conclusion: Non-surgical periodontal therapy may aid in the control of RA-related inflammatory markers in patients with CP. A large-scale study with well-defined populations is needed to clarify the benefit of non-surgical periodontal therapy. Keywords: Periodontitis, Anti-citrullinated protein antibodies, Tumor necrosis factor-α, Non-surgical periodontal treatment |
| first_indexed | 2024-12-10T13:19:48Z |
| format | Article |
| id | doaj.art-104ee7ca830d4fb1b46941051fdf2699 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-10T13:19:48Z |
| publishDate | 2018-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-104ee7ca830d4fb1b46941051fdf26992022-12-22T01:47:22ZengElsevierJournal of the Formosan Medical Association0929-66462018-11-011171110031010Significant association of rheumatoid arthritis-related inflammatory markers with non-surgical periodontal therapyNing-Ya Yang0Chen-Ying Wang1I-Tsu Chyuan2King-Jean Wu3Yu-Kang Tu4Ching-Wen Chang5Ping-Ning Hsu6Mark Yen-Ping Kuo7Yi-Wen Chen8Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Department of Periodontology, National Taiwan University Hospital, Taipei, Taiwan; Division of Periodontology, Department of Dentistry, Shuang Ho Hospital, Taipei Medical University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Department of Periodontology, National Taiwan University Hospital, Taipei, TaiwanDepartment of Internal Medicine, Cathay General Hospital, Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Department of Periodontology, National Taiwan University Hospital, Taipei, TaiwanGraduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Department of Periodontology, National Taiwan University Hospital, Taipei, TaiwanGraduate Institute of Immunology, College of Medicine, National Taiwan University, Department of Internal Medicine, National Taiwan University Hospital, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Department of Periodontology, National Taiwan University Hospital, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Department of Periodontology, National Taiwan University Hospital, Taipei, Taiwan; Corresponding author. Division of Periodontology, Department of Dentistry, National Taiwan University Hospital, No. 1, Chang-Te Street, Taipei 10048, Taiwan. Fax: +886 2 2383 1346.Background/Purpose: Chronic periodontitis (CP) and rheumatoid arthritis (RA) are the most common chronic inflammatory diseases and their immunopathogenesis is similar. The aim of this study was to evaluate the effect of non-surgical periodontal treatment on the serum levels of RA-related inflammatory markers in patients with chronic periodontitis. Methods: Thirty-one Taiwanese adults with CP were included. Demographics and periodontal parameters, including probing depth, clinical attachment level, and number of remaining teeth in the oral cavity, were recorded. All subjects received non-surgical periodontal treatment such as scaling and subgingival root planing. Serum samples were collected before and after the treatment. Serum levels of anti-citrullinated protein antibodies (ACPA), rheumatoid factor, tumor necrosis factor-α (TNF-α), C-reactive protein, interleukin-1β (IL-1β), and Interleukin-6 (IL-6) were measured using an enzyme-linked immunosorbent assay. Results: Non-surgical periodontal treatment significantly reduced the serum ACPA (p = 0.015) and TNF-α levels (p = 0.026) in CP patients, particularly in patients with generalized CP. Furthermore, there was a significant and positive correlation between the number of extracted teeth and the reduction in the serum ACPA (p = 0.05) and IL-1β levels (p = 0.029) after non-surgical periodontal treatment. Conclusion: Non-surgical periodontal therapy may aid in the control of RA-related inflammatory markers in patients with CP. A large-scale study with well-defined populations is needed to clarify the benefit of non-surgical periodontal therapy. Keywords: Periodontitis, Anti-citrullinated protein antibodies, Tumor necrosis factor-α, Non-surgical periodontal treatmenthttp://www.sciencedirect.com/science/article/pii/S0929664617307623 |
| spellingShingle | Ning-Ya Yang Chen-Ying Wang I-Tsu Chyuan King-Jean Wu Yu-Kang Tu Ching-Wen Chang Ping-Ning Hsu Mark Yen-Ping Kuo Yi-Wen Chen Significant association of rheumatoid arthritis-related inflammatory markers with non-surgical periodontal therapy Journal of the Formosan Medical Association |
| title | Significant association of rheumatoid arthritis-related inflammatory markers with non-surgical periodontal therapy |
| title_full | Significant association of rheumatoid arthritis-related inflammatory markers with non-surgical periodontal therapy |
| title_fullStr | Significant association of rheumatoid arthritis-related inflammatory markers with non-surgical periodontal therapy |
| title_full_unstemmed | Significant association of rheumatoid arthritis-related inflammatory markers with non-surgical periodontal therapy |
| title_short | Significant association of rheumatoid arthritis-related inflammatory markers with non-surgical periodontal therapy |
| title_sort | significant association of rheumatoid arthritis related inflammatory markers with non surgical periodontal therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0929664617307623 |
| work_keys_str_mv | AT ningyayang significantassociationofrheumatoidarthritisrelatedinflammatorymarkerswithnonsurgicalperiodontaltherapy AT chenyingwang significantassociationofrheumatoidarthritisrelatedinflammatorymarkerswithnonsurgicalperiodontaltherapy AT itsuchyuan significantassociationofrheumatoidarthritisrelatedinflammatorymarkerswithnonsurgicalperiodontaltherapy AT kingjeanwu significantassociationofrheumatoidarthritisrelatedinflammatorymarkerswithnonsurgicalperiodontaltherapy AT yukangtu significantassociationofrheumatoidarthritisrelatedinflammatorymarkerswithnonsurgicalperiodontaltherapy AT chingwenchang significantassociationofrheumatoidarthritisrelatedinflammatorymarkerswithnonsurgicalperiodontaltherapy AT pingninghsu significantassociationofrheumatoidarthritisrelatedinflammatorymarkerswithnonsurgicalperiodontaltherapy AT markyenpingkuo significantassociationofrheumatoidarthritisrelatedinflammatorymarkerswithnonsurgicalperiodontaltherapy AT yiwenchen significantassociationofrheumatoidarthritisrelatedinflammatorymarkerswithnonsurgicalperiodontaltherapy |